Mtor inhibition: A promise for a young heart

Frontiers in Physiology

Volumn 3 FEB, Issue , 2012, Pages

  Cau, Stefany B A ^a   Tostes, Rita C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84866284486     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2012.00031     Document Type: Note

References (8)

1. Brown, E. J., Albers, M. W., Shin, T. B., Ichikawa, K., Keith, C. T., Lane, W. S., and Schreiber, S. L. (1994). A mammalian protein targeted by G1-arresting rapamycinreceptor complex. Nature 369, 756-758.
2. Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., Pahor, M., Javors, M. A., Fernandez, E., and Miller, R. A. (2009). Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392-395.
3. Houde, V. P., Brule, S., Festuccia, W. T., Blanchard, P. G., Bellmann, K., Deshaies, Y., and Marette, A. (2010). Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. Diabetes 59, 1338-1348.
4. Kaeberlein, M., Powers, R. W. III, Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2005). Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 1193-1196.
5. Masoro, E. J. (2005). Overview of caloric restriction and ageing. Mech. Ageing Dev. 126, 913-922.
6. Ming, X.-F., Montani, J.-P., and Yang, Z. (2012). Perspectives of targeting mTORC1-S6K1 in cardiovascular aging. Front. Physiol. 3:5. doi: 10.3389/fphys.2012.00005
7. Vezina, C., Kudelski, A., and Sehgal, S. N. (1975). Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. 28, 721-726.
8. Weir, M. R., Diekmann, F., Flechner, S. M., Lebranchu, Y., Mandelbrot, D. A., Oberbauer, R., and Kahan, B. D. (2010). mTOR inhibition: the learning curve in kidney transplantation. Transpl. Int. 23, 447-460.