Hydroxylated biphenyl derivatives are positive modulators of human GABAA receptors

European Journal of Pharmacology

Volumn 693, Issue 1-3, 2012, Pages 45-50

  Paola Mascia, Maria ^a   Fabbri, Davide ^a   Antonietta Dettori, Maria ^a   Ledda, Giovanni ^b   Delogu, Giovanna ^a   Biggio, Giovanni ^a,b  

^a CNR   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

GABAA receptors; Hydroxylated biphenyl derivatives; Xenopus oocytes

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR BETA2; 4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; BIPHENYL DERIVATIVE; CHLORIDE ION; DIAZEPAM; ETOMIDATE; GLYCINE RECEPTOR; LIGAND GATED ION CHANNEL; NICOTINIC RECEPTOR; PENTOBARBITAL; PROPOFOL; SEROTONIN 3A RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHLORIDE CURRENT; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; DRUG SYNTHESIS; MALE; NEUROPROTECTION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SEIZURE; SENSITIVITY ANALYSIS; VOLTAGE CLAMP; XENOPUS LAEVIS;

ANIMALS; BEHAVIOR, ANIMAL; BIPHENYL COMPOUNDS; CELLS, CULTURED; GABA MODULATORS; HUMANS; HYDROXYLATION; MALE; OOCYTES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; XENOPUS LAEVIS;

EID: 84866275475     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.07.048     Document Type: Article

References (33)

1. E.A. Barnard, P. Skolnick, R.W. Olsen, H. Mohler, W. Sieghart, G. Biggio, C. Braestrup, A.N. Bateson, and S.Z. Langer International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function Pharmacol. Rev. 50 1998 291 313 (Pubitemid 28304030)
2. D. Belelli, and J.J. Lambert Neurosteroids: endogenous regulators of the GABA(A) receptor Nat. Rev. Neurosci. 6 2005 565 575 (Pubitemid 40942823)
3. J.R. Bloomquist Chloride channels as tools for developing selective insecticides Arch. Insect Biochem. Physiol. 54 2003 145 156 (Pubitemid 38592053)
4. J. Bormann The 'ABC' of GABA receptors Trends Pharmacol. Sci. 21 2000 16 19 (Pubitemid 30102186)
5. C. Braestrup, and M. Nielsen Discovery of beta-carboline ligands for benzodiazepine receptors Psychopharmacol. Ser. 11 1993 1 6
6. G. Bringman, A. Mortimer, P. Keller, M. Gresser, and M. Breuning Atroposelective synthesis of axially chiral biaryl compounds Angew. Chem. Int. Ed. Engl. 44 2005 5384 5427 (Pubitemid 41282514)
7. M. Chebib, and G.A. Johnston The 'ABC' of GABA receptors: a brief review Clin. Exp. Pharmacol. Physiol. 26 1999 937 940 (Pubitemid 29513638)
8. A. Colman Expression of exogenous DNA in Xenopus oocytes B.D. Hames, S.J. Higgins, Transcription and Translation: A Practical Approach 1984 Oxford University Press Washington, DC 49 59
9. K.R. Dallmeier Zelger, J.L. Zelger, and E.A. Carlini New anticonvulsants derived from 4-allyl-2-methoxyphenol (Eugenol): comparison with common antiepileptics in mice Pharmacology 27 1983 40 49 (Pubitemid 13107175)
10. A.M.P. De Diaz, H.E. Gottlieb, and O.R. Gottlieb Dehydrodieugenols from Ocotea cymbarum Phytochemistry 19 1980 681 682
11. G. Delogu, D. Fabbri, M.A. Dettori, A. Forni, and G. Casalone Enantiopure 2,2′- dihydroxy-3,3′-dimethoxy-5,5′-diallyl-6,6′- dibromo-1,1′-biphenyl: a conformationally stable C2-dimer of a eugenol derivative Tetrahedron: Asymmetry 15 2004 275 282 (Pubitemid 38068457)
12. N. Fakhrudin, A. Ladurner, A.G. Atanasov, E.H. Heiss, L. Baumgartner, P. Markt, D. Schuster, E.P. Ellmerer, G. Wolber, J.M. Rollinger, H. Stuppner, and V.M. Dirsch Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor gamma Mol. Pharmacol. 77 2010 559 566
13. D. Fabbri, M.A. Dettori, G. Delogu, A. Forni, G. Casalone, G. Palmieri, M. Pisano, and C. Rozzo 2,2′-Dihydroxy-3,3′-dimethoxy-5,5′- dimethyl-6,6′-dibromo-1,1′-biphenyl: preparation, resolution, structure and biological activity Tetrahedron: Asymmetry 18 2007 414 423 (Pubitemid 46367634)
14. M. Farrant, and Z. Nusser Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors Nat. Rev. Neurosci. 6 2005 215 229 (Pubitemid 40342416)
15. J. Feng, and J.M. Lipton Eugenol: antipyretic activity in rabbits Neuropharmacology 26 1987 1775 1778 (Pubitemid 18007662)
16. B. Gomez-Lor, A.M. Echavarren, and A. Santos Palladium-catalyzed synthesis of tetraethynyl and tetraethenyl biphenyls: elongated tetrahedral tectons Tetrahedron Lett. 38 1997 5347 5350 (Pubitemid 27300198)
17. J. Hyotylainen, J. Knuutinen, and E. Vilen Characterization of high molecular mass fractions of receiving waters and sediments of a pulp mill by CuO-oxidation and HPLC Chemosphere 30 1995 891 906
18. A. Isnansetyo, and Y. Kamei Pseudoalteromonas phenolica sp. nov., a novel marine bacterium that produces phenolic anti-methicillin-resistant Staphylococcus aureus substances Int. J. Syst. Evol. Microbiol. 53 2003 583 588 (Pubitemid 36416769)
19. B. Laube, G. Maksay, R. Schemm, and H. Betz Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses? Trends Pharmacol Sci. 23 2002 519 527 (Pubitemid 35292372)
20. E.D Levin Nicotinic receptor subtypes and cognitive function J Neurobiol. 53 2002 633 640 (Pubitemid 35375592)
21. F.A. Marques, F. Simonelli, A.R.M. Oliveira, G.L. Gohr, and P.C. Leal Oxidative coupling of 4-substituted 2-methoxy phenols using methyltributylammonium permanganate in dichloromethane Tetrahedron Lett. 39 1998 943 946 (Pubitemid 28122647)
22. M.P. Mascia, J.R. Trudell, and R.A. Harris Specific binding sites for alcohols and anesthetics on ligand-gated ion channels Proc. Natl. Acad. Sci. USA 97 2000 9305 9310 (Pubitemid 30626714)
23. A and glycine receptors Nature 389 1997 385 389 (Pubitemid 27415220)
24. H. Mohler, J.M. Fritschy, and U. Rudolph A new benzodiazepine pharmacology J. Pharmacol. Exp. Ther. 300 2002 2 8 (Pubitemid 34028501)
25. A.T. Peana, M.G. De Montis, S. Sechi, G. Sircana, P.S. D'Aquila, and P. Pippia Effects of (-)-linalool in the acute hyperalgesia induced by carrageenan, l-glutamate and prostaglandin E2 Eur. J. Pharmacol. 497 2004 279 284 (Pubitemid 39164892)
26. D.B. Pritchett, H. Sontheimer, B.D. Shivers, S. Ymer, H. Kettenmann, P.R. Schofield, and P.H Seeburg Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology Nature 338 1989 582 585 (Pubitemid 19102309)
27. A.C Reddy, and B.R. Lokesh Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron Mol. Cell. Biochem. 137 1994 1 8 (Pubitemid 24328842)
28. 3 receptor antagonists Scand. J. Rheumatol. Suppl. 119 2004 19 23 (Pubitemid 39180181)
29. A receptor subtypes: dissecting their pharmacological functions Trends Pharmacol. Sci. 22 2001 188 194 (Pubitemid 32244305)
30. A receptors J. Med. Chem. 41 1998 1846 1854 (Pubitemid 28248660)
31. M.B. Tyers, and A.J Freeman Mechanism of the anti-emetic activity of 5-HT3 receptor antagonists Oncology. 49 1992 263 268
32. A receptors by diflunisal analogues Neurochem. Int. 49 2006 676 682 (Pubitemid 44572570)
33. M.B. Wie, M.H. Won, K.H. Lee, J.H. Shin, J.C. Lee, H.W. Suh, D.K. Song, and Y.H. Kim Eugenol protects neuronal cells from excitotoxic and oxidative injury in primary cortical cultures Neurosci. Lett. 225 1997 93 96