A dopamine/noradrenaline reuptake inhibitor improves performance in the heat, but only at the maximum therapeutic dose

Scandinavian Journal of Medicine and Science in Sports

Volumn 22, Issue 5, 2012, Pages

  Roelands, B ^a   Watson, P ^b   Cordery, P ^b   Decoster, S ^a   Debaste, E ^a   Maughan, R ^b   Meeusen, R ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b LOUGHBOROUGH UNIVERSITY   (United Kingdom)

Author keywords

Bupropion; Central fatigue; Hot environment

Indexed keywords

AMFEBUTAMONE; DOPAMINE UPTAKE INHIBITOR; NORADRENALIN;

ADULT; ARTICLE; BICYCLE; BODY TEMPERATURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXERCISE TOLERANCE; HEAT; HUMAN; MALE; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SPORTS MEDICINE; STATISTICS; TASK PERFORMANCE;

ADULT; BICYCLING; BODY TEMPERATURE; BUPROPION; DOPAMINE UPTAKE INHIBITORS; EXERCISE TOLERANCE; HOT TEMPERATURE; HUMANS; MALE; NOREPINEPHRINE; SPORTS MEDICINE; STATISTICS AS TOPIC; TASK PERFORMANCE AND ANALYSIS;

EID: 84866274795     PISSN: 09057188     EISSN: 16000838     Source Type: Journal    
DOI: 10.1111/j.1600-0838.2012.01502.x     Document Type: Article

References (29)

1. Atkinson G. Analysis of repeated measurements in physical therapy research. Phys Ther Sport 2001: 2: 194-208.
2. Balit CR, Lynch CN, Isbister GK. Bupropion poisoning: a case series. Med J Aust 2003: 178 (2): 61-63.
3. Barnett A, Maughan RJ. Response of unacclimatized males to repeated weekly bouts of exercise in the heat. Br J Sports Med 1993: 27: 39-44.
4. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 1982: 14: 377-381.
5. Bredeloux P, Dubuc I, Constentin J. Comparisons between bupropion and dexamphetamine in a range of in vivo tests exploring dopaminergic transmission. Br J Pharmacol 2007: 150 (6): 711-719.
6. Chaouloff F. Physical exercise and brain monoamines: a review. Acta Physiol Scand 1989: 137 (1): 1-13.
7. Davis JM, Bailey SP. Possible mechanisms of central nervous system fatigue during exercise. Med Sci Sports Exerc 1997: 29 (1): 45-57.
8. Eichner R. Stimulants in sports. Curr Sports Med Rep 2008: 7: 244-245.
9. Egerton A, Shotbolt JP, Stokes PR, Hirani E, Ahmad R, Lappin JM, Reeves SJ, Mehta MA, Howes OD, Grasby PM. Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: an [11C]raclopride PET. Neuroimage 2010: 50 (1): 260-266.
10. Gerald MC. Effects of (+)-amphetamine on the treadmill endurance performance of rats. Neuropharmacology 1978: 17 (9): 703-704.
11. Hasegawa H, Meeusen R, Sarre S, Diltoer M, Piacentini MF, Michotte Y. Acute dopamine/noradrenaline reuptake inhibition increases brain and core temperature in rats. J Appl Physiol 2005: 99 (4): 1397-1401.
12. Hasegawa H, Piacentini MF, Sarre S, Michotte Y, Ishiwata T, Meeusen R. Influence of brain catecholamines on the development of fatigue in exercising rats in the heat. J Physiol 2008: 1: 141-149.
13. Heyes MP, Garnett ES, Coates G. Central dopaminergic activity influences rats ability to exercise. Life Sci 1985: 36 (7): 671-677.
14. Holm KJ, Spencer CM. Bupropion: a review of its use in the management of smoking cessation. Drugs 2000: 59: 1007-1024.
15. Ilyas S, Moncrieff J. Trends in prescriptions and costs of drugs for mental disorders in England, 1998-2010. Br J Psychiatry 2012: 200: 393-398.
16. Jeukendrup A, Saris WH, Brouns F, Kester AD. A new validated endurance performance test. Med Sci Sports Exerc 1996: 28: 266-270.
17. Machnik M, Sigmund G, Koch A, Thevis M, Schänzer W. Prevalence of antidepressants and biosimilars in elite sports. Drug Test Anal 2009: 1 (6): 286-291.
18. Muramoto ML, Leischow SJ, Sherrill D, Matthews E, Strayer LJ. Randomized, double-blind, placebo-controlled trial of 2 dosages of sustained-release bupropion for adolescent smoking cessation. Arch Pediatr Adolesc Med 2007: 161 (11): 1068-1074.
19. Nybo L. CNS fatigue provoked by prolonged exercise in the heat. Front Biosci 2010: 2: 779-792.
20. Piacentini MF, Clinckers R, Meeusen R, Sarre S, Ebinger G, Michotte Y. Effect of bupropion on hippocampal neurotransmitters and on peripheral hormonal concentrations in the rat. J Appl Physiol 2003: 95 (2): 652-656.
21. Piacentini MF, Meeusen R, Buyse L, De Schutter G, De Meirleir K. Hormonal responses during prolonged exercise are influenced by a selective DA/NA reuptake inhibitor. Br J Sports Med 2004: 38: 129-133.
22. Ramanathan LM. A new weighting system for mean surface temperature of the human body. J Appl Physiol 1964: 19: 531-532.
23. Roelands B, Goekint M, Heyman E, Piacentini MF, Watson P, Hasegawa H, Buyse L, Pauwels F, De Schutter G, Meeusen R. Acute noradrenaline reuptake inhibition decreases performance in normal and high ambient temperature. J Appl Physiol 2008b: 105: 206-212.
24. Roelands B, Hasegawa H, Watson P, Piacentini MF, Buyse L, De Schutter G, Meeusen R. Acute DA reuptake inhibition enhances performance in warm but not temperate conditions. Med Sci Sports Exerc 2008a: 40 (5): 879-858.
25. Roelands B, Hasegawa H, Watson P, Piacentini MF, Buyse L, De Schutter G, Meeusen R. Performance and thermoregulatory effect of chronic bupropion administration in the heat. Eur J Appl Physiol 2009: 105 (3): 493-498.
26. Roelands B, Meeusen R. Alterations in central fatigue by pharmacological manipulations of neurotransmitters in normal and high ambient temperatures. Sports Med 2010: 40 (3): 299-246.
27. Santamaria A, Arias HR. Neurochemical and behavioral effects elicited by bupropion and diethylpropion in rats. Behav Brain Res 2010: 211 (1): 132-139.
28. Sidhpura N, Redfern P, Rowley H, Heal D, Wonnacott S. Comparison of the effects of bupropion and nicotine on locomotor activation and dopamine release in vivo. Biochem Pharmacol 2007: 74 (8): 1292-1298.
29. Watson P, Hasegawa H, Roelands B, Piacentini MF, Looverie R, Meeusen R. Acute dopamine/noradrenaline reuptake inhibition enhances human exercise performance in warm, but not temperate conditions. J Physiol 2005: 565 (3): 873-883.