Pulsed photoacoustic Doppler flowmetry using time-domain cross-correlation: Accuracy, resolution and scalability

Journal of the Acoustical Society of America

Volumn 132, Issue 3, 2012, Pages 1780-1791

  Brunker, Joanna ^a   Beard, Paul ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BEAM WIDTHS; BLOOD VELOCITY; CENTER FREQUENCY; CONTINUOUS WAVES; CROSS CORRELATIONS; CROSS-CORRELATION FUNCTION; DOPPLER; DOPPLER FLOWMETRY; DOPPLER TECHNIQUES; LIGHT PULSE; MEASUREMENT RESOLUTION; MICRO-VASCULATURE; MICRON SCALE; PHOTOACOUSTIC WAVE; PZT; RESOLUTION MODES; SPATIALLY RESOLVED; TIME DOMAIN; TIME SHIFTS; ULTRASOUND TRANSDUCERS; WAVE FORMS;

BLOOD; MICROCIRCULATION; TIME DOMAIN ANALYSIS; TRANSDUCERS; ULTRASONIC TRANSDUCERS; VELOCITY MEASUREMENT;

VELOCITY;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BLOOD FLOW VELOCITY; ERYTHROCYTE; FEASIBILITY STUDY; HUMAN; IMAGE QUALITY; INSTRUMENTATION; LASER DOPPLER FLOWMETRY; METHODOLOGY; MICROCIRCULATION; PHOTOACOUSTICS; PHYSIOLOGY; REPRODUCIBILITY; SIGNAL PROCESSING; TIME; TRANSDUCER;

ANIMALS; BLOOD FLOW VELOCITY; ERYTHROCYTES; FEASIBILITY STUDIES; HUMANS; LASER-DOPPLER FLOWMETRY; MICROCIRCULATION; MODELS, CARDIOVASCULAR; PHANTOMS, IMAGING; PHOTOACOUSTIC TECHNIQUES; REPRODUCIBILITY OF RESULTS; SIGNAL PROCESSING, COMPUTER-ASSISTED; TIME FACTORS; TRANSDUCERS;

EID: 84866267961     PISSN: 00014966     EISSN: None     Source Type: Journal    
DOI: 10.1121/1.4739458     Document Type: Article

References (21)

1. P. Beard, Biomedical photoacoustic imaging., Interface Focus 1, 602-631 (2011). 10.1098/rsfs.2011.0028
2. J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy., J. Biomed. Opt. 17, 056016 (2012). 10.1117/1.JBO.17.5.056016
3. E. Z. Zhang, B. Povazay, J. Laufer, A. Alex, B. Hofer, B. Pedley, C. Glittenberg, B. Treeby, B. Cox, P. Beard, and W. Drexler, Multimodal photoacoustic and optical coherence tomography scanner using an all optical detection scheme for 3D morphological skin imaging., Biomed. Opt. Express 2, 2202-2215 (2011). 10.1364/BOE.2.002202
4. H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, Functional photoacoustic microscopy for high-resolution and noninvasive invivo imaging., Nat. Biotechnol. 24, 848-851 (2006). 10.1038/nbt1220
5. J. Laufer, D. Delpy, C. Elwell, and P. Beard, Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: Application to the measurement of blood oxygenation and haemoglobin concentration., Phys. Med. Biol. 52, 141-168 (2007). 10.1088/0031-9155/52/1/010
6. P. C. Beard, Flow velocity measurements., UK Patent Application WO 03/039364 (2001).
7. H. Fang, K. Maslov, and L. V. Wang, Photoacoustic doppler effect from flowing small light-absorbing particles., Phys. Rev. Lett. 99, 184501 (2007). 10.1103/PhysRevLett.99.184501
8. A. Sheinfeld, S. Gilead, and A. Eyal, Simultaneous spatial and spectral mapping of flow using photoacoustic Doppler measurement., J. Biomed. Opt. 15, 066010 (2010). 10.1117/1.3509113
9. J. Yao, K. Maslov, Y. Shi, L. Taber, and L. Wang, In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth., Opt. Lett. 35, 1419-1421 (2010). 10.1364/OL.35.001419
10. D. H. Evans and W. N. McDicken, Doppler Ultrasound: Physics, Instrumentation, and Signal Processing, 2nd ed. (Wiley, Chichester, 2000), pp. 229-284.
11. C. Kasai, A. Harada, and K. Namekawa, Real-time blood-flow imaging system using ultrasonic Doppler techniques., Syst. Comp. Jpn. 19, 13-24 (1988). 10.1002/scj.4690191102
12. J. Yao, K. I. Maslov, Y. Zhang, Y. Xia, and L. V. Wang, Label-free oxygen-metabolic photoacoustic microscopy invivo., J. Biomed. Optics 16, 076003 (2011). 10.1117/1.3594786
13. S.-L. Chen, Z. Xie, P. L. Carson, X. Wang, and L. J. Guo, In vivo flow speed measurement of capillaries by photoacoustic correlation spectroscopy., Opt. Lett. 36, 4017-4019 (2011). 10.1364/OL.36.004017
14. O. Bonnefous and P. Pesque, Time domain formulation of pulse-Doppler ultrasound and blood velocity estimation by cross correlation., Ultrasonic Imaging 85, 73-85 (1986). 10.1016/0161-7346(86)90001-5
15. I. A. Hein and W. R. O'Brien, Current time-domain methods for assessing tissue motion by analysis from reflected ultrasound echoes-A review., IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 40, 84-102 (1993). 10.1109/58.212556
16. J. Brunker and P. Beard, Pulsed photoacoustic Doppler flowmetry using a cross correlation method. in Proc. SPIE Int. Soc. Opt. Eng., pp. 756426 (2010).
17. J. Brunker and P. Beard, Pulsed photoacoustic Doppler flow measurements in blood-mimicking phantoms. in Proc. SPIE Int. Soc. Opt. Eng., p. 78991K (2011).
18. M. Sarimollaoglu, D. A. Nedosekin, Y. Simanovsky, E. I. Galanzha, and V. P. Zharov, In vivo photoacoustic time-of-flight velocity measurement of single cells and nanoparticles., Opt. Lett. 36, 4086-4088 (2011). 10.1364/OL.36.004086
19. Analysis of Sensory-Motor Control Performance. in The Biomedical Engineering Handbook, 2nd ed., edited by, J. Bronzino, (CRC Press, 2000), p. 149:17.
20. Observations of sections from healthy tissue., University of Cambridge, Department of Pathology, (Last viewed 20 December 2011).
21. B. J. Bain, Morphology of Blood Cells. in Blood Cells: A Practical Guide, 3rd ed. (Wiley-Blackwell, 2002), pp. 52-154.