Clinical significance of elevated alpha-foetoprotein (AFP) in patients with chronic hepatitis C without hepatocellular carcinoma in upper EGYPT

Arab Journal of Gastroenterology

Volumn 13, Issue 2, 2012, Pages 49-53

  Kobeisy, Mohammad A ^a   Morsy, Khairy H ^b   Galal, Mohammad ^c   Sayed, Sohair K ^b   Ashmawy, Mohammad M ^a   Mohammad, Fattahallah M ^a  

^a ASSIUT UNIVERSITY   (Egypt)

^b Assiut University Faculty of Medicine   (Egypt)

^c Assiut University   (Egypt)

Author keywords

Alpha foetoprotein; Chronic hepatitis C; Hepatocellular carcinoma

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA FETOPROTEIN;

ABDOMINAL RADIOGRAPHY; ADULT; ARTICLE; COHORT ANALYSIS; FEMALE; HEPATITIS C; HUMAN; LIVER CELL CARCINOMA; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; NUCLEAR MAGNETIC RESONANCE IMAGING; POPULATION RESEARCH; PREVALENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; THROMBOCYTE COUNT; ULTRASOUND;

ADULT; ALANINE TRANSAMINASE; ALPHA-FETOPROTEINS; ANALYSIS OF VARIANCE; ASPARTATE AMINOTRANSFERASES; EGYPT; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PLATELET COUNT; ROC CURVE; SENSITIVITY AND SPECIFICITY; THROMBOCYTOPENIA; VIRAL LOAD; YOUNG ADULT;

EID: 84866266908     PISSN: 16871979     EISSN: 20902387     Source Type: Journal    
DOI: 10.1016/j.ajg.2012.06.004     Document Type: Article

References (24)

1. Mohamed M.K. Epidemiology of HCV in Egypt. Afro-Arab Liver J 2004, 3:41-52.
2. Lee C.M., Hung C.H., Lu S.N., et al. Hepatitis C virus genotypes: clinical relevance and therapeutic implications. Chang Gung Med J 2008, 31(1):16-25.
3. Tai W.C., Hu T.H., Wang J.H., et al. Clinical implications of alpha-fetoprotein in chronic hepatitis C. J Formos Med Assoc 2009, 108(3):210-218.
4. Esmat G., Shaker M.K., El Folly R.F., et al. Towards an Egyptian guideline from screening to treatment of hepatocellular carcinoma. Afro-Arab Liver J 2009, 8(2):77-81.
5. Tateyama M., Yatsuhashi H., Taura N., et al. Alpha-fetoprotein above normal levels as a risk factor for the development of hepatocellular carcinoma in patients infected with hepatitis C virus. J Gastroenterol 2011, 46(1):92-100.
6. Chen T.M., Huang P.T., Tsai M.H., et al. Predictors of alpha-fetoprotein elevation in patients with chronic hepatitis C, but not hepatocellular carcinoma and its normalization after pegylated interferon alfa 2a-ribavirin combination therapy. J Gastroenterol Hepatol 2007, 22(5):669-675.
7. El Zayadi A.R., Badran H.M., Barakat E.M.F., et al. Hepatocellular carcinoma in Egypt: a single center study over a decade. World J Gastroenterol 2005, 11(33):5193-5198.
8. Di Bisceglie A.M., Sterling R.K., Chung R.T., et al. Serum alpha-fetoprotein levels in patients with advanced hepatitis C: results from the HALT-C trial. J Hepatol 2005, 43(3):434-441.
9. Chu C.W., Hwang S.J., Luo J.C., et al. Clinical, virologic and pathologic significance of elevated serum alpha-fetoprotein levels in patients with chronic hepatitis C. J Clin Gastroenterol 2001, 32(3):240-244.
10. Hu K.Q., Kyulo N.L., Lim N., et al. Clinical significance of elevated alpha-fetoprotein (AFP) in patients with chronic hepatitis C, but not hepatocellular carcinoma. Am J Gastroenterol 2004, 99(5):860-865.
11. Li Q., Luan G., Guo Q., et al. A new class of homogeneous nucleic acid probes based on specific displacement hybridization. Nucleic Acids Res 2002, 30(2):E5.
12. Giachetti C., Linnen J.M., Kolk D.P., et al. Highly sensitive multiplex assay for detection of human immunodeficiency virus type 1 and hepatitis C virus RNA. J Clin Microbiol 2002, 40(7):2408-2419.
13. Wittwer C.T., Kusukawa N. Real-time PCR. Diagnostic molecular microbiology: principles and applications 2004, 71-84. ASM Press, Washington. D.H. Presing, F.C. Tenover, D.A. Relman (Eds.).
14. Batts K.P., Ludwig J. Chronic hepatitis: an update on terminology and reporting. Am J Surg Pathol 1995, 19(12):1409-1417.
15. Fattovich G., Giustina G., Degos F., et al. Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients. Gastroenterology 1997, 112(2):463-472.
16. Sato Y., Nakata K., Kato Y., et al. Early recognition of hepatocellular carcinoma based on altered profiles of alpha-fetoprotein. N Engl J Med 1993, 328(25):1802-1806.
17. Tong M.J., El Farra N.S., Reikes A.R., et al. Clinical outcomes after transfusion-associated hepatitis C. N Engl J Med 1995, 332(22):1463-1466.
18. Bruden D.L., McMahon B.J., Hennessy T.W., et al. Estimating the date of hepatitis C virus infection from patient interviews and antibody tests on stored sera. Am J Gastroenterol 2004, 99(8):1517-1522.
19. Bruce M.G., Bruden D., McMahon B.J., et al. Clinical significance of elevated alpha-fetoprotein in Alaskan native patients with chronic hepatitis C. J Viral Hepat 2008, 15(3):179-187.
20. Murashima S., Tanaka M., Haramaki M., et al. A decrease in AFP level related to administration of interferon in patients with chronic hepatitis C and a high level of AFP. Dig Dis Sci 2006, 51(4):808-812.
21. Yu M.L., Chuang W.L., Chen S.C., et al. Changing prevalence of hepatitis C virus genotypes: molecular epidemiology and clinical implications in tertiary referral center in Taiwan. J Med Virol 2001, 65:58-65.
22. Chen C.H., Lin S.T., Kuo C.L., et al. Clinical significance of elevated alpha-fetoprotein (AFP) in chronic hepatitis C without hepatocellular carcinoma. Hepatogastroenterology 2008, 55(85):1423-1427.
23. Lu S.N., Wang J.H., Liu S.L., et al. Thrombocytopenia as a surrogate for cirrhosis and a marker for the identification of patients at high-risk for hepatocellular carcinoma. Cancer 2006, 107(9):2212-2222.
24. Bayati N., Silverman A.L., Gordon S.C. Serum alpha-fetoprotein levels and liver histology in patients with chronic hepatitis C. Am J Gastroenterol 1998, 93(12):2452-2456.