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Volumn 46, Issue 1, 2011, Pages 92-100

Alpha-fetoprotein above normal levels as a risk factor for the development of hepatocellular carcinoma in patients infected with hepatitis C virus

Author keywords

Alpha fetoprotein; Hepatitis C virus; Hepatocellular carcinoma

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALPHA FETOPROTEIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; HEPATITIS C VIRUS CORE ANTIGEN; INTERFERON; PEGINTERFERON; RIBAVIRIN; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

EID: 78651511517     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-010-0293-6     Document Type: Article
Times cited : (76)

References (55)
  • 1
    • 4444365401 scopus 로고    scopus 로고
    • The natural history of hepatitis C
    • 10.1055/s-2004-832922 15346240
    • NH Afdhal 2004 The natural history of hepatitis C Semin Liver Dis 24 Suppl 2 3 8 10.1055/s-2004-832922 15346240
    • (2004) Semin Liver Dis , vol.24 , Issue.SUPPL. 2 , pp. 3-8
    • Afdhal, N.H.1
  • 2
    • 20444407284 scopus 로고    scopus 로고
    • Virology. Culture systems for hepatitis C virus in sight at last
    • 1:CAS:528:DC%2BD2MXlt1Snsro%3D 10.1126/science.308.5728.1539 15947152
    • J Cohen 2005 Virology. Culture systems for hepatitis C virus in sight at last Science 308 1539 1541 1:CAS:528:DC%2BD2MXlt1Snsro%3D 10.1126/science.308. 5728.1539 15947152
    • (2005) Science , vol.308 , pp. 1539-1541
    • Cohen, J.1
  • 3
    • 20344392430 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology, risk factors, and screening
    • 10.1055/s-2005-871194 15918143
    • M Sherman 2005 Hepatocellular carcinoma: epidemiology, risk factors, and screening Semin Liver Dis 25 143 154 10.1055/s-2005-871194 15918143
    • (2005) Semin Liver Dis , vol.25 , pp. 143-154
    • Sherman, M.1
  • 4
    • 34250679750 scopus 로고    scopus 로고
    • Epidemiology of hepatitis C virus infection
    • 17552026
    • MJ Alter 2007 Epidemiology of hepatitis C virus infection World J Gastroenterol 13 2436 2441 17552026
    • (2007) World J Gastroenterol , vol.13 , pp. 2436-2441
    • Alter, M.J.1
  • 5
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • 1:CAS:528:DC%2BD2sXnvFOgsrw%3D 10.1053/j.gastro.2007.04.061 17570226
    • HB El-Serag KL Rudolph 2007 Hepatocellular carcinoma: epidemiology and molecular carcinogenesis Gastroenterology 132 2557 2576 1:CAS:528: DC%2BD2sXnvFOgsrw%3D 10.1053/j.gastro.2007.04.061 17570226
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 6
    • 0033520109 scopus 로고    scopus 로고
    • Interferon therapy reduces the risk for hepatocellular carcinoma: National surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT Study Group. Inhibition of Hepatocarcinogenesis by Interferon Therapy
    • 1:CAS:528:DyaK1MXlsVCrtbo%3D 10428733
    • H Yoshida Y Shiratori M Moriyama Y Arakawa T Ide M Sata, et al. 1999 Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT Study Group. Inhibition of Hepatocarcinogenesis by Interferon Therapy Ann Intern Med 131 174 181 1:CAS:528:DyaK1MXlsVCrtbo%3D 10428733
    • (1999) Ann Intern Med , vol.131 , pp. 174-181
    • Yoshida, H.1    Shiratori, Y.2    Moriyama, M.3    Arakawa, Y.4    Ide, T.5    Sata, M.6
  • 7
    • 7044272621 scopus 로고    scopus 로고
    • Pathogenesis of hepatitis C-associated hepatocellular carcinoma
    • 1:CAS:528:DC%2BD2cXhtVGmtb7F 10.1053/j.gastro.2004.09.017 15508105
    • TJ Liang T Heller 2004 Pathogenesis of hepatitis C-associated hepatocellular carcinoma Gastroenterology 127 S62 S71 1:CAS:528: DC%2BD2cXhtVGmtb7F 10.1053/j.gastro.2004.09.017 15508105
    • (2004) Gastroenterology , vol.127
    • Liang, T.J.1    Heller, T.2
  • 8
    • 0035192821 scopus 로고    scopus 로고
    • The role of liver biopsy in chronic hepatitis C
    • 1:STN:280:DC%2BD3M%2FpvV2qug%3D%3D 10.1053/jhep.2001.20534 11124836
    • S Saadeh G Cammell WD Carey Z Younossi D Barnes K Easley 2001 The role of liver biopsy in chronic hepatitis C Hepatology 33 196 200 1:STN:280: DC%2BD3M%2FpvV2qug%3D%3D 10.1053/jhep.2001.20534 11124836
    • (2001) Hepatology , vol.33 , pp. 196-200
    • Saadeh, S.1    Cammell, G.2    Carey, W.D.3    Younossi, Z.4    Barnes, D.5    Easley, K.6
  • 9
    • 0036829484 scopus 로고    scopus 로고
    • Role of liver biopsy in management of chronic hepatitis C: A systematic review
    • 10.1002/hep.1840360721 12407590
    • KA Gebo HF Herlong MS Torbenson MW Jenckes G Chander KG Ghanem, et al. 2002 Role of liver biopsy in management of chronic hepatitis C: a systematic review Hepatology 36 S161 S172 10.1002/hep.1840360721 12407590
    • (2002) Hepatology , vol.36
    • Gebo, K.A.1    Herlong, H.F.2    Torbenson, M.S.3    Jenckes, M.W.4    Chander, G.5    Ghanem, K.G.6
  • 10
    • 0036792679 scopus 로고    scopus 로고
    • Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
    • 10.1111/j.1572-0241.2002.06038.x 12385448
    • A Regev M Berho LJ Jeffers C Milikowski EG Molina NT Pyrsopoulos, et al. 2002 Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection Am J Gastroenterol 97 2614 2618 10.1111/j.1572-0241.2002. 06038.x 12385448
    • (2002) Am J Gastroenterol , vol.97 , pp. 2614-2618
    • Regev, A.1    Berho, M.2    Jeffers, L.J.3    Milikowski, C.4    Molina, E.G.5    Pyrsopoulos, N.T.6
  • 11
    • 33751018880 scopus 로고    scopus 로고
    • A simple noninvasive index for predicting long-term outcome of chronic hepatitis C after interferon-based therapy
    • 1:CAS:528:DC%2BD28Xht1aktL7P 10.1002/hep.21363 17058238
    • ML Yu SM Lin CM Lee CY Dai WY Chang SC Chen, et al. 2006 A simple noninvasive index for predicting long-term outcome of chronic hepatitis C after interferon-based therapy Hepatology 44 1086 1097 1:CAS:528:DC%2BD28Xht1aktL7P 10.1002/hep.21363 17058238
    • (2006) Hepatology , vol.44 , pp. 1086-1097
    • Yu, M.L.1    Lin, S.M.2    Lee, C.M.3    Dai, C.Y.4    Chang, W.Y.5    Chen, S.C.6
  • 12
    • 0032814693 scopus 로고    scopus 로고
    • Platelet count reflects stage of chronic hepatitis C
    • 10.1016/S1386-6346(98)00075-8
    • E Ono Y Shiratori T Okudaira M Imamura T Teratani F Kanai, et al. 1999 Platelet count reflects stage of chronic hepatitis C Hepatol Res 15 192 200 10.1016/S1386-6346(98)00075-8
    • (1999) Hepatol Res , vol.15 , pp. 192-200
    • Ono, E.1    Shiratori, Y.2    Okudaira, T.3    Imamura, M.4    Teratani, T.5    Kanai, F.6
  • 13
    • 0033940858 scopus 로고    scopus 로고
    • Natural course of progression of liver fibrosis in Japanese patients with chronic liver disease type C-a study of 527 patients at one establishment
    • 1:STN:280:DC%2BD3cvntVCmsg%3D%3D 10.1046/j.1365-2893.2000.00235.x 10886535
    • H Matsumura M Moriyama I Goto N Tanaka H Okubo Y Arakawa 2000 Natural course of progression of liver fibrosis in Japanese patients with chronic liver disease type C-a study of 527 patients at one establishment J Viral Hepat 7 268 275 1:STN:280:DC%2BD3cvntVCmsg%3D%3D 10.1046/j.1365-2893.2000.00235.x 10886535
    • (2000) J Viral Hepat , vol.7 , pp. 268-275
    • Matsumura, H.1    Moriyama, M.2    Goto, I.3    Tanaka, N.4    Okubo, H.5    Arakawa, Y.6
  • 14
    • 0035190894 scopus 로고    scopus 로고
    • Serum aminotransferase levels and platelet counts as predictors of degree of fibrosis in chronic hepatitis C virus infection
    • 1:CAS:528:DC%2BD3MXpt1Kmtbw%3D 10.1111/j.1572-0241.2001.05268.x 11721762
    • A Pohl C Behling D Oliver M Kilani P Monson T Hassanein 2001 Serum aminotransferase levels and platelet counts as predictors of degree of fibrosis in chronic hepatitis C virus infection Am J Gastroenterol 96 3142 3146 1:CAS:528:DC%2BD3MXpt1Kmtbw%3D 10.1111/j.1572-0241.2001.05268.x 11721762
    • (2001) Am J Gastroenterol , vol.96 , pp. 3142-3146
    • Pohl, A.1    Behling, C.2    Oliver, D.3    Kilani, M.4    Monson, P.5    Hassanein, T.6
  • 15
    • 0033917644 scopus 로고    scopus 로고
    • Hepatitis C virus related cirrhosis: Time to occurrence of hepatocellular carcinoma and death
    • 1:STN:280:DC%2BD3czitVOqtw%3D%3D 10.1136/gut.47.1.131 10861275
    • F Degos C Christidis N Ganne-Carrie JP Farmachidi C Degott C Guettier, et al. 2000 Hepatitis C virus related cirrhosis: time to occurrence of hepatocellular carcinoma and death Gut 47 131 136 1:STN:280: DC%2BD3czitVOqtw%3D%3D 10.1136/gut.47.1.131 10861275
    • (2000) Gut , vol.47 , pp. 131-136
    • Degos, F.1    Christidis, C.2    Ganne-Carrie, N.3    Farmachidi, J.P.4    Degott, C.5    Guettier, C.6
  • 16
    • 33847010888 scopus 로고    scopus 로고
    • Clinical and pathological factors associated with the development of hepatocellular carcinoma in patients with hepatitis virus-related cirrhosis: A long-term follow-up study
    • 1:STN:280:DC%2BD2s7lvFOmtQ%3D%3D
    • JL Rodriguez-Diaz V Rosas-Camargo O Vega-Vega D Morales-Espinosa A Mendez-Reguera JL Martinez-Tlahuel, et al. 2007 Clinical and pathological factors associated with the development of hepatocellular carcinoma in patients with hepatitis virus-related cirrhosis: a long-term follow-up study Clin Oncol (R Coll Radiol) 19 197 203 1:STN:280:DC%2BD2s7lvFOmtQ%3D%3D
    • (2007) Clin Oncol (R Coll Radiol) , vol.19 , pp. 197-203
    • Rodriguez-Diaz, J.L.1    Rosas-Camargo, V.2    Vega-Vega, O.3    Morales-Espinosa, D.4    Mendez-Reguera, A.5    Martinez-Tlahuel, J.L.6
  • 17
    • 0028235641 scopus 로고
    • Classification of chronic hepatitis: Diagnosis, grading and staging
    • 1:STN:280:DyaK2c3ksFWisw%3D%3D 10.1002/hep.1840190629 8188183
    • VJ Desmet M Gerber JH Hoofnagle M Manns PJ Scheuer 1994 Classification of chronic hepatitis: diagnosis, grading and staging Hepatology 19 1513 1520 1:STN:280:DyaK2c3ksFWisw%3D%3D 10.1002/hep.1840190629 8188183
    • (1994) Hepatology , vol.19 , pp. 1513-1520
    • Desmet, V.J.1    Gerber, M.2    Hoofnagle, J.H.3    Manns, M.4    Scheuer, P.J.5
  • 18
    • 0032904921 scopus 로고    scopus 로고
    • Development of a simple and highly sensitive enzyme immunoassay for hepatitis C virus core antigen
    • 1:CAS:528:DyaK1MXjslSrtb8%3D 10325327
    • K Aoyagi C Ohue K Iida T Kimura E Tanaka K Kiyosawa, et al. 1999 Development of a simple and highly sensitive enzyme immunoassay for hepatitis C virus core antigen J Clin Microbiol 37 1802 1808 1:CAS:528:DyaK1MXjslSrtb8%3D 10325327
    • (1999) J Clin Microbiol , vol.37 , pp. 1802-1808
    • Aoyagi, K.1    Ohue, C.2    Iida, K.3    Kimura, T.4    Tanaka, E.5    Kiyosawa, K.6
  • 19
    • 0033854022 scopus 로고    scopus 로고
    • Evaluation of a new enzyme immunoassay for hepatitis C virus (HCV) core antigen with clinical sensitivity approximating that of genomic amplification of HCV RNA
    • 1:CAS:528:DC%2BD3cXlvVyjtLo%3D 10.1053/jhep.2000.9112 10915747
    • E Tanaka C Ohue K Aoyagi K Yamaguchi S Yagi K Kiyosawa, et al. 2000 Evaluation of a new enzyme immunoassay for hepatitis C virus (HCV) core antigen with clinical sensitivity approximating that of genomic amplification of HCV RNA Hepatology 32 388 393 1:CAS:528:DC%2BD3cXlvVyjtLo%3D 10.1053/jhep.2000.9112 10915747
    • (2000) Hepatology , vol.32 , pp. 388-393
    • Tanaka, E.1    Ohue, C.2    Aoyagi, K.3    Yamaguchi, K.4    Yagi, S.5    Kiyosawa, K.6
  • 20
    • 0027522145 scopus 로고
    • Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region
    • 1:CAS:528:DyaK2cXkvFOhtA%3D%3D 10.1099/0022-1317-74-11-2391 8245854
    • P Simmonds EC Holmes TA Cha SW Chan F McOmish B Irvine, et al. 1993 Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region J Gen Virol 74 Pt 11 2391 2399 1:CAS:528:DyaK2cXkvFOhtA%3D%3D 10.1099/0022-1317-74-11-2391 8245854
    • (1993) J Gen Virol , vol.74 , Issue.PART 11 , pp. 2391-2399
    • Simmonds, P.1    Holmes, E.C.2    Cha, T.A.3    Chan, S.W.4    McOmish, F.5    Irvine, B.6
  • 21
    • 0031059949 scopus 로고    scopus 로고
    • New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a
    • 1:CAS:528:DyaK2sXktVKksA%3D%3D 8968908
    • O Ohno M Mizokami RR Wu MG Saleh K Ohba E Orito, et al. 1997 New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a J Clin Microbiol 35 201 207 1:CAS:528:DyaK2sXktVKksA%3D%3D 8968908
    • (1997) J Clin Microbiol , vol.35 , pp. 201-207
    • Ohno, O.1    Mizokami, M.2    Wu, R.R.3    Saleh, M.G.4    Ohba, K.5    Orito, E.6
  • 22
    • 0034234726 scopus 로고    scopus 로고
    • Analysis of factors affecting the appearance of hepatocellular carcinoma in patients with chronic hepatitis C. A long term follow-up study after histologic diagnosis
    • 1:STN:280:DC%2BD3czlslSnsw%3D%3D 10.1002/1097-0142(20000701)89:1<53:: AID-CNCR8>3.0.CO;2-6 10897000
    • Y Aizawa Y Shibamoto I Takagi M Zeniya G Toda 2000 Analysis of factors affecting the appearance of hepatocellular carcinoma in patients with chronic hepatitis C. A long term follow-up study after histologic diagnosis Cancer 89 53 59 1:STN:280:DC%2BD3czlslSnsw%3D%3D 10.1002/1097-0142(20000701)89:1<53::AID- CNCR8>3.0.CO;2-6 10897000
    • (2000) Cancer , vol.89 , pp. 53-59
    • Aizawa, Y.1    Shibamoto, Y.2    Takagi, I.3    Zeniya, M.4    Toda, G.5
  • 23
    • 7044272630 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in cirrhosis: Incidence and risk factors
    • 10.1053/j.gastro.2004.09.014 15508101
    • G Fattovich T Stroffolini I Zagni F Donato 2004 Hepatocellular carcinoma in cirrhosis: incidence and risk factors Gastroenterology 127 S35 S50 10.1053/j.gastro.2004.09.014 15508101
    • (2004) Gastroenterology , vol.127
    • Fattovich, G.1    Stroffolini, T.2    Zagni, I.3    Donato, F.4
  • 25
    • 28844480321 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma
    • 10.1002/hep.20933 16250051
    • J Bruix M Sherman 2005 Management of hepatocellular carcinoma Hepatology 42 1208 1236 10.1002/hep.20933 16250051
    • (2005) Hepatology , vol.42 , pp. 1208-1236
    • Bruix, J.1    Sherman, M.2
  • 26
    • 0025887360 scopus 로고
    • Hepatocellular carcinoma in Italian patients with cirrhosis
    • 1:STN:280:DyaK3MzjtlKktg%3D%3D 10.1056/NEJM199109053251002 1651452
    • M Colombo R de Franchis E Del Ninno A Sangiovanni C De Fazio M Tommasini, et al. 1991 Hepatocellular carcinoma in Italian patients with cirrhosis N Engl J Med 325 675 680 1:STN:280:DyaK3MzjtlKktg%3D%3D 10.1056/NEJM199109053251002 1651452
    • (1991) N Engl J Med , vol.325 , pp. 675-680
    • Colombo, M.1    De Franchis, R.2    Del Ninno, E.3    Sangiovanni, A.4    De Fazio, C.5    Tommasini, M.6
  • 27
    • 0027243462 scopus 로고
    • Risk factors for hepatocellular carcinoma among patients with chronic liver disease
    • 1:STN:280:DyaK3s3nsFektg%3D%3D 10.1056/NEJM199306243282501 7684822
    • H Tsukuma T Hiyama S Tanaka M Nakao T Yabuuchi T Kitamura, et al. 1993 Risk factors for hepatocellular carcinoma among patients with chronic liver disease N Engl J Med 328 1797 1801 1:STN:280:DyaK3s3nsFektg%3D%3D 10.1056/NEJM199306243282501 7684822
    • (1993) N Engl J Med , vol.328 , pp. 1797-1801
    • Tsukuma, H.1    Hiyama, T.2    Tanaka, S.3    Nakao, M.4    Yabuuchi, T.5    Kitamura, T.6
  • 28
    • 0028180445 scopus 로고
    • Prospective study of alpha-fetoprotein in cirrhotic patients monitored for development of hepatocellular carcinoma
    • 1:STN:280:DyaK2c7gt1Ojuw%3D%3D 10.1002/hep.1840190111 7506227
    • H Oka A Tamori T Kuroki K Kobayashi S Yamamoto 1994 Prospective study of alpha-fetoprotein in cirrhotic patients monitored for development of hepatocellular carcinoma Hepatology 19 61 66 1:STN:280:DyaK2c7gt1Ojuw%3D%3D 10.1002/hep.1840190111 7506227
    • (1994) Hepatology , vol.19 , pp. 61-66
    • Oka, H.1    Tamori, A.2    Kuroki, T.3    Kobayashi, K.4    Yamamoto, S.5
  • 29
    • 15844411099 scopus 로고    scopus 로고
    • Predictive score for the development of hepatocellular carcinoma and additional value of liver large cell dysplasia in Western patients with cirrhosis
    • 1:STN:280:DyaK283gs1Gnsw%3D%3D 10.1002/hep.510230527 8621142
    • N Ganne-Carrie C Chastang F Chapel C Munz D Pateron M Sibony, et al. 1996 Predictive score for the development of hepatocellular carcinoma and additional value of liver large cell dysplasia in Western patients with cirrhosis Hepatology 23 1112 1118 1:STN:280:DyaK283gs1Gnsw%3D%3D 10.1002/hep.510230527 8621142
    • (1996) Hepatology , vol.23 , pp. 1112-1118
    • Ganne-Carrie, N.1    Chastang, C.2    Chapel, F.3    Munz, C.4    Pateron, D.5    Sibony, M.6
  • 30
    • 0034998728 scopus 로고    scopus 로고
    • Hepatocyte proliferation and risk of hepatocellular carcinoma in cirrhotic patients
    • 1:STN:280:DC%2BD3M3ptF2jtw%3D%3D 10.1111/j.1572-0241.2001.03780.x 11374702
    • A Sangiovanni E Colombo F Radaelli A Bortoli G Bovo MA Casiraghi, et al. 2001 Hepatocyte proliferation and risk of hepatocellular carcinoma in cirrhotic patients Am J Gastroenterol 96 1575 1580 1:STN:280:DC%2BD3M3ptF2jtw%3D%3D 10.1111/j.1572-0241.2001.03780.x 11374702
    • (2001) Am J Gastroenterol , vol.96 , pp. 1575-1580
    • Sangiovanni, A.1    Colombo, E.2    Radaelli, F.3    Bortoli, A.4    Bovo, G.5    Casiraghi, M.A.6
  • 31
    • 33646141135 scopus 로고    scopus 로고
    • Prediction model of hepatocarcinogenesis for patients with hepatitis C virus-related cirrhosis. Validation with internal and external cohorts
    • 1:CAS:528:DC%2BD28XksVaisbw%3D 10.1016/j.jhep.2006.02.008 16618514
    • K Ikeda Y Arase S Saitoh M Kobayashi T Someya T Hosaka, et al. 2006 Prediction model of hepatocarcinogenesis for patients with hepatitis C virus-related cirrhosis. Validation with internal and external cohorts J Hepatol 44 1089 1097 1:CAS:528:DC%2BD28XksVaisbw%3D 10.1016/j.jhep.2006.02.008 16618514
    • (2006) J Hepatol , vol.44 , pp. 1089-1097
    • Ikeda, K.1    Arase, Y.2    Saitoh, S.3    Kobayashi, M.4    Someya, T.5    Hosaka, T.6
  • 32
    • 38449092083 scopus 로고    scopus 로고
    • Clinical significance of elevated alpha-fetoprotein in Alaskan Native patients with chronic hepatitis C
    • 1:STN:280:DC%2BD1c%2FnslertA%3D%3D 10.1111/j.1365-2893.2007.00928.x 18233991
    • MG Bruce D Bruden BJ McMahon C Christensen C Homan D Sullivan, et al. 2008 Clinical significance of elevated alpha-fetoprotein in Alaskan Native patients with chronic hepatitis C J Viral Hepat 15 179 187 1:STN:280: DC%2BD1c%2FnslertA%3D%3D 10.1111/j.1365-2893.2007.00928.x 18233991
    • (2008) J Viral Hepat , vol.15 , pp. 179-187
    • Bruce, M.G.1    Bruden, D.2    McMahon, B.J.3    Christensen, C.4    Homan, C.5    Sullivan, D.6
  • 33
    • 0025696558 scopus 로고
    • Alpha-fetoprotein: Reevaluation in hepatology
    • 1:CAS:528:DyaK3MXkvV2qtbY%3D 10.1002/hep.1840120625 1701754
    • K Taketa 1990 Alpha-fetoprotein: reevaluation in hepatology Hepatology 12 1420 1432 1:CAS:528:DyaK3MXkvV2qtbY%3D 10.1002/hep.1840120625 1701754
    • (1990) Hepatology , vol.12 , pp. 1420-1432
    • Taketa, K.1
  • 34
    • 0035116742 scopus 로고    scopus 로고
    • Clinical, virologic, and pathologic significance of elevated serum alpha-fetoprotein levels in patients with chronic hepatitis C
    • 1:STN:280:DC%2BD3M7mslGrug%3D%3D 10.1097/00004836-200103000-00014 11246354
    • CW Chu SJ Hwang JC Luo CR Lai SH Tsay CP Li, et al. 2001 Clinical, virologic, and pathologic significance of elevated serum alpha-fetoprotein levels in patients with chronic hepatitis C J Clin Gastroenterol 32 240 244 1:STN:280:DC%2BD3M7mslGrug%3D%3D 10.1097/00004836-200103000-00014 11246354
    • (2001) J Clin Gastroenterol , vol.32 , pp. 240-244
    • Chu, C.W.1    Hwang, S.J.2    Luo, J.C.3    Lai, C.R.4    Tsay, S.H.5    Li, C.P.6
  • 35
    • 0344036236 scopus 로고    scopus 로고
    • Grading and staging of hepatic fibrosis, and its relationship with noninvasive diagnostic parameters
    • 14606100
    • LG Lu MD Zeng MB Wan CZ Li YM Mao JQ Li, et al. 2003 Grading and staging of hepatic fibrosis, and its relationship with noninvasive diagnostic parameters World J Gastroenterol 9 2574 2578 14606100
    • (2003) World J Gastroenterol , vol.9 , pp. 2574-2578
    • Lu, L.G.1    Zeng, M.D.2    Wan, M.B.3    Li, C.Z.4    Mao, Y.M.5    Li, J.Q.6
  • 36
    • 2942675194 scopus 로고    scopus 로고
    • Clinical significance of elevated alpha-fetoprotein (AFP) in patients with chronic hepatitis C, but not hepatocellular carcinoma
    • 1:CAS:528:DC%2BD2cXlt1CjtbY%3D 10.1111/j.1572-0241.2004.04152.x 15128351
    • KQ Hu NL Kyulo N Lim B Elhazin DJ Hillebrand T Bock 2004 Clinical significance of elevated alpha-fetoprotein (AFP) in patients with chronic hepatitis C, but not hepatocellular carcinoma Am J Gastroenterol 99 860 865 1:CAS:528:DC%2BD2cXlt1CjtbY%3D 10.1111/j.1572-0241.2004.04152.x 15128351
    • (2004) Am J Gastroenterol , vol.99 , pp. 860-865
    • Hu, K.Q.1    Kyulo, N.L.2    Lim, N.3    Elhazin, B.4    Hillebrand, D.J.5    Bock, T.6
  • 37
    • 3142729289 scopus 로고    scopus 로고
    • Hepatocyte proliferation in chronic hepatitis C: Correlation with degree of liver disease and serum alpha-fetoprotein
    • 1:STN:280:DC%2BD2c3ovFGjsQ%3D%3D 10.1111/j.1478-3231.2004.00907.x 15189269
    • P Wilfredo Canchis SA Gonzalez M Isabel Fiel L Chiriboga H Yee BR Edlin, et al. 2004 Hepatocyte proliferation in chronic hepatitis C: correlation with degree of liver disease and serum alpha-fetoprotein Liver Int 24 198 203 1:STN:280:DC%2BD2c3ovFGjsQ%3D%3D 10.1111/j.1478-3231.2004.00907.x 15189269
    • (2004) Liver Int , vol.24 , pp. 198-203
    • Wilfredo Canchis, P.1    Gonzalez, S.A.2    Isabel Fiel, M.3    Chiriboga, L.4    Yee, H.5    Edlin, B.R.6
  • 38
    • 23444432469 scopus 로고    scopus 로고
    • Serum alpha-fetoprotein levels in patients with advanced hepatitis C: Results from the HALT-C trial
    • 1:CAS:528:DC%2BD2MXntVCkurc%3D 10.1016/j.jhep.2005.03.019 16136646
    • AM Di Bisceglie RK Sterling RT Chung JE Everhart JL Dienstag HL Bonkovsky, et al. 2005 Serum alpha-fetoprotein levels in patients with advanced hepatitis C: results from the HALT-C trial J Hepatol 43 434 441 1:CAS:528:DC%2BD2MXntVCkurc%3D 10.1016/j.jhep.2005.03.019 16136646
    • (2005) J Hepatol , vol.43 , pp. 434-441
    • Di Bisceglie, A.M.1    Sterling, R.K.2    Chung, R.T.3    Everhart, J.E.4    Dienstag, J.L.5    Bonkovsky, H.L.6
  • 39
    • 0028876371 scopus 로고
    • Randomised trial of effects of interferon-alpha on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis
    • 1:CAS:528:DyaK2MXpsl2lurY%3D 10.1016/S0140-6736(95)91739-X 7564784
    • S Nishiguchi T Kuroki S Nakatani H Morimoto T Takeda S Nakajima, et al. 1995 Randomised trial of effects of interferon-alpha on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis Lancet 346 1051 1055 1:CAS:528:DyaK2MXpsl2lurY%3D 10.1016/S0140-6736(95)91739-X 7564784
    • (1995) Lancet , vol.346 , pp. 1051-1055
    • Nishiguchi, S.1    Kuroki, T.2    Nakatani, S.3    Morimoto, H.4    Takeda, T.5    Nakajima, S.6
  • 40
    • 37149041579 scopus 로고    scopus 로고
    • Long-term effects of interferon-based therapy for chronic hepatitis C
    • 1:CAS:528:DC%2BD2sXhsVels7bJ 10.1159/000111703 18087178
    • ML Yu CF Huang CY Dai JF Huang WL Chuang 2007 Long-term effects of interferon-based therapy for chronic hepatitis C Oncology 72 Suppl 1 16 23 1:CAS:528:DC%2BD2sXhsVels7bJ 10.1159/000111703 18087178
    • (2007) Oncology , vol.72 , Issue.SUPPL. 1 , pp. 16-23
    • Yu, M.L.1    Huang, C.F.2    Dai, C.Y.3    Huang, J.F.4    Chuang, W.L.5
  • 41
    • 0343111507 scopus 로고    scopus 로고
    • Relation of interferon therapy and hepatocellular carcinoma in patients with chronic hepatitis C. Osaka Hepatocellular Carcinoma Prevention Study Group
    • 1:CAS:528:DyaK1cXlt1emsbk%3D 9669992
    • Y Imai S Kawata S Tamura I Yabuuchi S Noda M Inada, et al. 1998 Relation of interferon therapy and hepatocellular carcinoma in patients with chronic hepatitis C. Osaka Hepatocellular Carcinoma Prevention Study Group Ann Intern Med 129 94 99 1:CAS:528:DyaK1cXlt1emsbk%3D 9669992
    • (1998) Ann Intern Med , vol.129 , pp. 94-99
    • Imai, Y.1    Kawata, S.2    Tamura, S.3    Yabuuchi, I.4    Noda, S.5    Inada, M.6
  • 42
    • 17344369924 scopus 로고    scopus 로고
    • Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C. Osaka Liver Disease Study Group
    • 1:CAS:528:DyaK1cXjtVSjt7Y%3D 10.1002/hep.510270529 9581697
    • A Kasahara N Hayashi K Mochizuki M Takayanagi K Yoshioka S Kakumu, et al. 1998 Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C. Osaka Liver Disease Study Group Hepatology 27 1394 1402 1:CAS:528:DyaK1cXjtVSjt7Y%3D 10.1002/hep.510270529 9581697
    • (1998) Hepatology , vol.27 , pp. 1394-1402
    • Kasahara, A.1    Hayashi, N.2    Mochizuki, K.3    Takayanagi, M.4    Yoshioka, K.5    Kakumu, S.6
  • 43
    • 0032898360 scopus 로고    scopus 로고
    • Effect of interferon therapy on hepatocellular carcinogenesis in patients with chronic hepatitis type C: A long-term observation study of 1,643 patients using statistical bias correction with proportional hazard analysis
    • 1:CAS:528:DyaK1MXisVKgsLk%3D 10.1002/hep.510290439 10094956
    • K Ikeda S Saitoh Y Arase K Chayama Y Suzuki M Kobayashi, et al. 1999 Effect of interferon therapy on hepatocellular carcinogenesis in patients with chronic hepatitis type C: a long-term observation study of 1,643 patients using statistical bias correction with proportional hazard analysis Hepatology 29 1124 1130 1:CAS:528:DyaK1MXisVKgsLk%3D 10.1002/hep.510290439 10094956
    • (1999) Hepatology , vol.29 , pp. 1124-1130
    • Ikeda, K.1    Saitoh, S.2    Arase, Y.3    Chayama, K.4    Suzuki, Y.5    Kobayashi, M.6
  • 44
    • 0036590390 scopus 로고    scopus 로고
    • Transient biochemical response in interferon therapy decreases the development of hepatocellular carcinoma for five years and improves the long-term survival of chronic hepatitis C patients
    • 1:CAS:528:DC%2BD38XltlakurY%3D 10.1016/S1386-6346(02)00016-5 12084557
    • T Okanoue Y Itoh T Kirishima Y Daimon T Toyama A Morita, et al. 2002 Transient biochemical response in interferon therapy decreases the development of hepatocellular carcinoma for five years and improves the long-term survival of chronic hepatitis C patients Hepatol Res 23 62 77 1:CAS:528: DC%2BD38XltlakurY%3D 10.1016/S1386-6346(02)00016-5 12084557
    • (2002) Hepatol Res , vol.23 , pp. 62-77
    • Okanoue, T.1    Itoh, Y.2    Kirishima, T.3    Daimon, Y.4    Toyama, T.5    Morita, A.6
  • 45
    • 0347287026 scopus 로고    scopus 로고
    • Interferon therapy as chemoprevention of hepatocarcinogenesis in patients with chronic hepatitis C
    • 1:CAS:528:DC%2BD3sXhtVShsbrN 10.1093/jac/dkh031 14657083
    • K Hino K Okita 2004 Interferon therapy as chemoprevention of hepatocarcinogenesis in patients with chronic hepatitis C J Antimicrob Chemother 53 19 22 1:CAS:528:DC%2BD3sXhtVShsbrN 10.1093/jac/dkh031 14657083
    • (2004) J Antimicrob Chemother , vol.53 , pp. 19-22
    • Hino, K.1    Okita, K.2
  • 46
    • 0032997086 scopus 로고    scopus 로고
    • Treatment of hepatitis C virus-related cirrhosis: A randomized, controlled trial of interferon alfa-2b versus no treatment
    • 1:CAS:528:DyaK1MXjvFOmsbw%3D 10.1002/hep.510290616 10347132
    • DC Valla M Chevallier P Marcellin JL Payen C Trepo M Fonck, et al. 1999 Treatment of hepatitis C virus-related cirrhosis: a randomized, controlled trial of interferon alfa-2b versus no treatment Hepatology 29 1870 1875 1:CAS:528:DyaK1MXjvFOmsbw%3D 10.1002/hep.510290616 10347132
    • (1999) Hepatology , vol.29 , pp. 1870-1875
    • Valla, D.C.1    Chevallier, M.2    Marcellin, P.3    Payen, J.L.4    Trepo, C.5    Fonck, M.6
  • 47
    • 3042547162 scopus 로고    scopus 로고
    • The impact of antiviral treatments on the course of chronic hepatitis C: An evidence-based approach
    • 1:CAS:528:DC%2BD2cXltFCnurs%3D 10.2174/1381612043384321 15279551
    • C Camma D Di Bona A Craxi 2004 The impact of antiviral treatments on the course of chronic hepatitis C: an evidence-based approach Curr Pharm Des 10 2123 2130 1:CAS:528:DC%2BD2cXltFCnurs%3D 10.2174/1381612043384321 15279551
    • (2004) Curr Pharm des , vol.10 , pp. 2123-2130
    • Camma, C.1    Di Bona, D.2    Craxi, A.3
  • 48
    • 0032736213 scopus 로고    scopus 로고
    • A randomized, controlled trial of maintenance interferon therapy for patients with chronic hepatitis C virus and persistent viremia
    • 1:CAS:528:DyaK1MXnsVCqtro%3D 10.1016/S0016-5085(99)70402-6 10535880
    • ML Shiffman CM Hofmann MJ Contos VA Luketic AJ Sanyal RK Sterling, et al. 1999 A randomized, controlled trial of maintenance interferon therapy for patients with chronic hepatitis C virus and persistent viremia Gastroenterology 117 1164 1172 1:CAS:528:DyaK1MXnsVCqtro%3D 10.1016/S0016-5085(99)70402-6 10535880
    • (1999) Gastroenterology , vol.117 , pp. 1164-1172
    • Shiffman, M.L.1    Hofmann, C.M.2    Contos, M.J.3    Luketic, V.A.4    Sanyal, A.J.5    Sterling, R.K.6
  • 49
    • 0036911875 scopus 로고    scopus 로고
    • Normalization of markedly elevated alpha-fetoprotein in a virologic nonresponder with HCV-related cirrhosis
    • 10.1023/A:1021044803279 12498286
    • DF Stein M Myaing 2002 Normalization of markedly elevated alpha-fetoprotein in a virologic nonresponder with HCV-related cirrhosis Dig Dis Sci 47 2686 2690 10.1023/A:1021044803279 12498286
    • (2002) Dig Dis Sci , vol.47 , pp. 2686-2690
    • Stein, D.F.1    Myaing, M.2
  • 50
    • 33645848470 scopus 로고    scopus 로고
    • A decrease in AFP level related to administration of interferon in patients with chronic hepatitis C and a high level of AFP
    • 1:CAS:528:DC%2BD28XjsFSls7w%3D 10.1007/s10620-006-3211-2 16615008
    • S Murashima M Tanaka M Haramaki S Yutani Y Nakashima K Harada, et al. 2006 A decrease in AFP level related to administration of interferon in patients with chronic hepatitis C and a high level of AFP Dig Dis Sci 51 808 812 1:CAS:528:DC%2BD28XjsFSls7w%3D 10.1007/s10620-006-3211-2 16615008
    • (2006) Dig Dis Sci , vol.51 , pp. 808-812
    • Murashima, S.1    Tanaka, M.2    Haramaki, M.3    Yutani, S.4    Nakashima, Y.5    Harada, K.6
  • 51
    • 0032991093 scopus 로고    scopus 로고
    • Interferon alfa receptor expression and growth inhibition by interferon alfa in human liver cancer cell lines
    • 1:CAS:528:DyaK1MXjvFOmsL8%3D 10.1002/hep.510290624 10347112
    • H Yano A Iemura M Haramaki S Ogasawara A Takayama J Akiba, et al. 1999 Interferon alfa receptor expression and growth inhibition by interferon alfa in human liver cancer cell lines Hepatology 29 1708 1717 1:CAS:528: DyaK1MXjvFOmsL8%3D 10.1002/hep.510290624 10347112
    • (1999) Hepatology , vol.29 , pp. 1708-1717
    • Yano, H.1    Iemura, A.2    Haramaki, M.3    Ogasawara, S.4    Takayama, A.5    Akiba, J.6
  • 52
    • 0033566684 scopus 로고    scopus 로고
    • Association between high serum alanine aminotransferase levels and more rapid development and higher rate of incidence of hepatocellular carcinoma in patients with hepatitis C virus-associated cirrhosis
    • 1:CAS:528:DyaK1MXlslSmtr0%3D 10.1002/(SICI)1097-0142(19990815)86: 4<589::AID-CNCR7>3.0.CO;2-K 10440686
    • K Tarao Y Rino S Ohkawa A Shimizu S Tamai K Miyakawa, et al. 1999 Association between high serum alanine aminotransferase levels and more rapid development and higher rate of incidence of hepatocellular carcinoma in patients with hepatitis C virus-associated cirrhosis Cancer 86 589 595 1:CAS:528:DyaK1MXlslSmtr0%3D 10.1002/(SICI)1097-0142(19990815)86:4<589::AID- CNCR7>3.0.CO;2-K 10440686
    • (1999) Cancer , vol.86 , pp. 589-595
    • Tarao, K.1    Rino, Y.2    Ohkawa, S.3    Shimizu, A.4    Tamai, S.5    Miyakawa, K.6
  • 53
    • 0037086457 scopus 로고    scopus 로고
    • Close association between high serum alanine aminotransferase levels and multicentric hepatocarcinogenesis in patients with hepatitis C virus-associated cirrhosis
    • 10.1002/cncr.10391 11920542
    • K Tarao Y Rino S Ohkawa S Tamai K Miyakawa H Takakura, et al. 2002 Close association between high serum alanine aminotransferase levels and multicentric hepatocarcinogenesis in patients with hepatitis C virus-associated cirrhosis Cancer 94 1787 1795 10.1002/cncr.10391 11920542
    • (2002) Cancer , vol.94 , pp. 1787-1795
    • Tarao, K.1    Rino, Y.2    Ohkawa, S.3    Tamai, S.4    Miyakawa, K.5    Takakura, H.6
  • 54
    • 0141888970 scopus 로고    scopus 로고
    • Long-term outcome, with monitoring of platelet counts, in patients with chronic hepatitis C and liver cirrhosis after interferon therapy
    • 1:CAS:528:DC%2BD3sXotVejuro%3D 10.1159/000073209 14555850
    • M Moriyama H Matsumura H Aoki T Shimizu K Nakai T Saito, et al. 2003 Long-term outcome, with monitoring of platelet counts, in patients with chronic hepatitis C and liver cirrhosis after interferon therapy Intervirology 46 296 307 1:CAS:528:DC%2BD3sXotVejuro%3D 10.1159/000073209 14555850
    • (2003) Intervirology , vol.46 , pp. 296-307
    • Moriyama, M.1    Matsumura, H.2    Aoki, H.3    Shimizu, T.4    Nakai, K.5    Saito, T.6
  • 55
    • 0037369657 scopus 로고    scopus 로고
    • Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis
    • 10.1053/jhep.2003.50093 12601348
    • RF Velazquez M Rodriguez CA Navascues A Linares R Perez NG Sotorrios, et al. 2003 Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis Hepatology 37 520 527 10.1053/jhep.2003.50093 12601348
    • (2003) Hepatology , vol.37 , pp. 520-527
    • Velazquez, R.F.1    Rodriguez, M.2    Navascues, C.A.3    Linares, A.4    Perez, R.5    Sotorrios, N.G.6


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