Determination of ofloxacin in tear by HPLC-ESI-MS/MS method: Comparison of ophthalmic drug release between a new mucoadhesive chitosan films and a conventional eye drop formulation in rabbit model

Journal of Pharmaceutical and Biomedical Analysis

Volumn 70, Issue , 2012, Pages 544-548

  Byrro, Ricardo Martins Duarte ^a   de Oliveira Fulgêncio, Gustavo ^a   da Silva Cunha, Armando ^a   César, Isabela Costa ^a   Chellini, Paula Rocha ^a   Pianetti, Gerson Antônio ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Controlled release; HPLC ESI MS MS; Ofloxacin; Ophthalmic delivery; Rabbit; Tear

Indexed keywords

CHITOSAN; EYE DROPS; FORMIC ACID; METHANOL; OFLOXACIN; POLYMER;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; LACRIMAL FLUID; LIQUID LIQUID EXTRACTION; MALE; MEDICAL DEVICE; MUCOADHESION; NONHUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; TEAR FILM;

ADHESIVENESS; ADMINISTRATION, OPHTHALMIC; ANIMALS; ANTI-BACTERIAL AGENTS; CALIBRATION; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; FORMATES; LIMIT OF DETECTION; MALE; METHANOL; MODELS, ANIMAL; OFLOXACIN; OPHTHALMIC SOLUTIONS; RABBITS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TEARS;

EID: 84866244723     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.05.003     Document Type: Article

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