Development, validation and comparison of two microextraction techniques for the rapid and sensitive determination of pregabalin in urine and pharmaceutical formulations after ethyl chloroformate derivatization followed by gas chromatography-mass spectrometric analysis

Journal of Pharmaceutical and Biomedical Analysis

Volumn 70, Issue , 2012, Pages 310-319

  Mudiam, Mohana Krishna Reddy ^a   Chauhan, Abhishek ^a   Jain, Rajeev ^a   Ch, Ratnasekhar ^a   Fatima, Ghizal ^b   Malhotra, Ekta ^a   Murthy, R C ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b KING GEORGE'S MEDICAL UNIVERSITY   (India)

Author keywords

Dispersive liquid liquid microextraction; Ethyl chloroformate derivatization; Gas chromatography mass spectrometry; Pregabalin; Solid phase microextraction

Indexed keywords

CHLOROFORMIC ACID ETHYL ESTER; PREGABALIN; PYRIDINE;

ARTICLE; COST EFFECTIVENESS ANALYSIS; DERIVATIZATION; DISPERSIVE LIQUID LIQUID MICROEXTRACTION; DRUG DETERMINATION; DRUG FORMULATION; DRUG ISOLATION; DRUG STRUCTURE; INTERMETHOD COMPARISON; LIMIT OF QUANTITATION; LIQUID PHASE MICROEXTRACTION; MASS FRAGMENTOGRAPHY; PRIORITY JOURNAL; QUALITY CONTROL; ROOM TEMPERATURE; SOLID PHASE MICROEXTRACTION; URINALYSIS;

ANALGESICS; ANTICONVULSANTS; CHEMISTRY, PHARMACEUTICAL; DOSAGE FORMS; FORMIC ACID ESTERS; GAMMA-AMINOBUTYRIC ACID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROGEN-ION CONCENTRATION; LIMIT OF DETECTION; LIQUID PHASE MICROEXTRACTION; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE MICROEXTRACTION; SOLVENTS; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS; URINALYSIS;

EID: 84866241262     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.05.001     Document Type: Article

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