Neural dynamics of choice: Single-trial analysis of decision-related activity in parietal cortex

Journal of Neuroscience

Volumn 32, Issue 37, 2012, Pages 12684-12701

  Bollimunta, Anil ^a,c   Totten, Douglas ^a   Ditterich, Jochen ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; DECISION MAKING; FEMALE; HIDDEN MARKOV MODEL; MACACA MULATTA; MALE; MAXIMUM LIKELIHOOD METHOD; MOVEMENT PERCEPTION; NERVE CELL NETWORK; NERVE FUNCTION; NONHUMAN; PARIETAL CORTEX; POISSON DISTRIBUTION; PRIORITY JOURNAL; RESPONSE TIME; SACCADIC EYE MOVEMENT; SPIKE WAVE; TASK PERFORMANCE; VISUAL DISCRIMINATION; VISUAL STIMULATION;

ANIMALS; CHOICE BEHAVIOR; COMPUTER SIMULATION; FEMALE; MACACA MULATTA; MALE; MODELS, NEUROLOGICAL; MODELS, STATISTICAL; MOTION PERCEPTION; NERVE NET; PARIETAL LOBE;

EID: 84866238591     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5752-11.2012     Document Type: Article

References (39)

1. Abeles M, Bergman H, Gat I, Meilijson I, Seidemann E, Tishby N, Vaadia E (1995) Cortical activity flips among quasi-stationary states. Proc Natl Acad Sci U S A 92:8616-8620.
2. Baras JS, Finesso L (1992) Consistent estimation of the order of hidden Markov chains. Lect Notes Contr Inf 184:26-39.
3. Bennur S, Gold JI (2011) Distinct representations of a perceptual decision and the associated oculomotor plan in the monkey lateral intraparietal area. J Neurosci 31:913-921.
4. Bogacz R, Brown E, Moehlis J, Holmes P, Cohen JD (2006) The physics of optimal decision making: a formal analysis of models of performance in two-alternative forced-choice tasks. Psychol Rev 113:700-765.
5. Bollimunta A, Ditterich J (2012) Local computation of decision-relevant net sensory evidence in parietal cortex. Cereb Cortex 22:903-917.
6. Bollimunta A, Knuth KH, Ding M (2007) Trial-by-trial estimation of amplitude and latency variability in neuronal spike trains. J Neurosci Methods 160:163-170.
7. Churchland AK, Kiani R, Shadlen MN (2008) Decision-making with multiple alternatives. Nat Neurosci 11:693-702.
8. Churchland AK, Kiani R, Chaudhuri R, Wang XJ, Pouget A, Shadlen MN (2011) Variance as a signature of neural computations during decision making. Neuron 69:818-831.
9. Deco G, Rolls ET, Romo R (2009) Stochastic dynamics as a principle of brain function. Prog Neurobiol 88:1-16.
10. Ditterich J (2006) Stochastic models of decisions about motion direction: behavior and physiology. Neural Netw 19:981-1012.
11. Ditterich J (2010) A comparison between mechanisms of multi-alternative perceptual decision making: ability to explain human behavior, predictions for neurophysiology, and relationship with decision theory. Front Neurosci 4:184.
12. Durstewitz D, Deco G (2008) Computational significance of transient dynamics in cortical networks. Eur J Neurosci 27:217-227.
13. Gat I, Tishby N, Abeles M (1997) Hidden Markov modelling of simultaneously recorded cells in the associative cortex of behaving monkeys. Network 8:297-322.
14. Gold JI, Shadlen MN (2001) Neural computations that underlie decisions about sensory stimuli. Trends Cogn Sci 5:10-16.
15. Gregory PC (2005) Bayesian logical data analysis for the physical sciences: a comparative approach with Mathematica support. Cambridge, UK: Cambridge UP.
16. Hannan EJ, Quinn BG (1979) Determination of the order of an autoregression. J R Stat Soc Series B Stat Methodol 41:190-195.
17. Horwitz GD, Newsome WT (2001) Target selection for saccadic eye movements: prelude activity in the superior colliculus during a directiondiscrimination task. J Neurophysiol 86:2543-2558.
18. Huk AC, Shadlen MN (2005) Neural activity in macaque parietal cortex reflects temporal integration of visual motion signals during perceptual decision making. J Neurosci 25:10420-10436.
19. Jones LM, Fontanini A, Sadacca BF, Miller P, Katz DB (2007) Natural stimuli evoke dynamic sequences of states in sensory cortical ensembles. Proc Natl Acad Sci U S A 104:18772-18777.
20. Kiani R, Hanks TD, Shadlen MN (2008) Bounded integration in parietal cortex underlies decisions even when viewing duration is dictated by the environment. J Neurosci 28:3017-3029.
21. Kim JN, Shadlen MN (1999) Neural correlates of a decision in the dorsolateral prefrontal cortex of the macaque. Nat Neurosci 2:176-185.
22. Law CT, Gold JI (2008) Neural correlates of perceptual learning in a sensory-motor, but not a sensory, cortical area. Nat Neurosci 11:505-513.
23. Maimon G, Assad JA (2009) Beyond Poisson: increased spike-time regularity across primate parietal cortex. Neuron 62:426-440.
24. Mazurek ME, Roitman JD, Ditterich J, Shadlen MN (2003) A role for neural integrators in perceptual decision making. Cereb Cortex 13:1257-1269.
25. McCane B, Caelli T (2004) Diagnostic tools for evaluating and updating hidden Markov models. Pattern Recogn 37:1325-1337.
26. McMillen T, Holmes P (2006) The dynamics of choice among multiple alternatives. J Math Psychol 50:30-57.
27. Miller P, Katz DB (2010) Stochastic transitions between neural states in taste processing and decision-making. J Neurosci 30:2559-2570.
28. Radons G, Becker JD, Dülfer B, Krüger J (1994) Analysis, classification, and coding of multielectrode spike trains with hidden Markov models. Biol Cybern 71:359-373.
29. Ratcliff R, McKoon G (2008) The diffusion decision model: theory and data for two-choice decision tasks. Neural Comput 20:873-922.
30. Resulaj A, Kiani R, Wolpert DM, Shadlen MN (2009) Changes of mind in decision-making. Nature 461:263-266.
31. Roitman JD, Shadlen MN (2002) Response of neurons in the lateral intraparietal area during a combined visual discrimination reaction time task. J Neurosci 22:9475-9489.
32. Rorie AE, Gao J, McClelland JL, Newsome WT (2010) Integration of sensory and reward information during perceptual decision-making in lateral intraparietal cortex (LIP) of the macaque monkey. PLo S One 5:e9308.
33. Seidemann E, Meilijson I, Abeles M, Bergman H, Vaadia E (1996) Simultaneously recorded single units in the frontal cortex go through sequences of discrete and stable states in monkeys performing a delayed localization task. J Neurosci 16:752-768.
34. Seung HS (1996) How the brain keeps the eyes still. Proc Natl Acad Sci U S A 93:13339-13344.
35. Shadlen MN, Newsome WT (1998) The variable discharge of cortical neurons: implications for connectivity, computation, and information coding. J Neurosci 18:3870-3896.
36. Shadlen MN, Newsome WT (2001) Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey. J Neurophysiol 86:1916-1936.
37. Softky WR, Koch C (1993) The highly irregular firing of cortical cells is inconsistent with temporal integration of random EPSPs. J Neurosci 13:334-350.
38. Usher M, McClelland JL (2001) The time course of perceptual choice: the leaky, competing accumulator model. Psychol Rev 108:550-592.
39. Wong KF, Wang XJ (2006) A recurrent network mechanism of time integration in perceptual decisions. J Neurosci 26:1314-1328.