Variance as a Signature of Neural Computations during Decision Making

Neuron

Volumn 69, Issue 4, 2011, Pages 818-831

  Churchland, Anne K ^a,f   Kiani, R ^b,e   Chaudhuri, R ^c   Wang, Xiao Jing ^c   Pouget, Alexandre ^d   Shadlen, M N ^a,e  

^a UNIVERSITY OF WASHINGTON   (United States)

^b STANFORD UNIVERSITY   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF ROCHESTER   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^f Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; DECISION MAKING; INTRAPARIETAL SULCUS; MENTAL TASK; NERVE EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; SPIKE; STATISTICAL ANALYSIS; STEREOTYPY; STIMULUS RESPONSE; VARIANCE;

ACTION POTENTIALS; ANIMALS; COMPUTER SIMULATION; DECISION MAKING; HAPLORHINI; MODELS, NEUROLOGICAL; MOTION PERCEPTION; NEURONS; NUMERICAL ANALYSIS, COMPUTER-ASSISTED; PHOTIC STIMULATION; REACTION TIME; STATISTICS AS TOPIC; STOCHASTIC PROCESSES; TIME FACTORS;

EID: 79951685112     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2010.12.037     Document Type: Article

References (49)

1. Aertsen A.M., Gerstein G.L., Habib M.K., Palm G. Dynamics of neuronal firing correlation: Modulation of " effective connectivity" J. Neurophysiol. 1989, 61:900-917.
2. Albantakis L., Deco G. The encoding of alternatives in multiple-choice decision making. Proc. Natl. Acad. Sci. USA 2009, 106:10308-10313.
3. Balan P.F., Oristaglio J., Schneider D.M., Gottlieb J. Neuronal correlates of the set-size effect in monkey lateral intraparietal area. PLoS Biol. 2008, 6:e158.
4. Barlow H.B. Retinal noise and absolute threshold. J. Opt. Soc. Am. 1956, 46:634-639.
5. Basso M.A., Wurtz R.H. Modulation of neuronal activity in superior colliculus by changes in target probability. J. Neurosci. 1998, 18:7519-7534.
6. Beck J.M., Ma W.J., Kiani R., Hanks T., Churchland A.K., Roitman J., Shadlen M.N., Latham P.E., Pouget A. Probabilistic population codes for Bayesian decision making. Neuron 2008, 60:1142-1152.
7. Berry M.J., Meister M. Refractoriness and neural precision. J. Neurosci. 1998, 18:2200-2211.
8. Bogacz R., Brown E., Moehlis J., Holmes P., Cohen J.D. The physics of optimal decision making: A formal analysis of models of performance in two-alternative forced-choice tasks. Psychol. Rev. 2006, 113:700-765.
9. Britten K.H., Newsome W.T., Shadlen M.N., Celebrini S., Movshon J.A. A relationship between behavioral choice and the visual responses of neurons in macaque MT. Vis. Neurosci. 1996, 13:87-100.
10. Britten K.H., Shadlen M.N., Newsome W.T., Movshon J.A. The analysis of visual motion: A comparison of neuronal and psychophysical performance. J. Neurosci. 1992, 12:4745-4765.
11. Britten K.H., Shadlen M.N., Newsome W.T., Movshon J.A. Responses of neurons in macaque MT to stochastic motion signals. Vis. Neurosci. 1993, 10:1157-1169.
12. Bulmer M.G., Howarth C.I., Cane V., Gregory R.L., Barlow H.B. Noise and the visual threshold. Nature 1957, 180:1403-1405.
13. Carpenter R.H., Williams M.L. Neural computation of log likelihood in control of saccadic eye movements. Nature 1995, 377:59-62.
14. Churchland A.K., Kiani R., Shadlen M.N. Decision-making with multiple alternatives. Nat. Neurosci. 2008, 11:693-702.
15. Churchland M.M., Yu B.M., Cunningham J.P., Sugrue L.P., Cohen M.R., Corrado G.S., Newsome W.T., Clark A.M., Hosseini P., Scott B.B., et al. Stimulus onset quenches neural variability: A widespread cortical phenomenon. Nat. Neurosci. 2010, 13:369-378.
16. Churchland M.M., Yu B.M., Ryu S.I., Santhanam G., Shenoy K.V. Neural variability in premotor cortex provides a signature of motor preparation. J. Neurosci. 2006, 26:3697-3712.
17. Cisek P., Puskas G.A., El-Murr S. Decisions in changing conditions: The urgency-gating model. J. Neurosci. 2009, 29:11560-11571.
18. Cox D.R., Isham V. Point Processes 1980, Chapman and Hall, London, New York.
19. Daley D.J., Vere-Jones D. Elementary theory and methods. An Introduction to the Theory of Point Processes 2003, Springer, New York.
20. Faisal A.A., Selen L.P., Wolpert D.M. Noise in the nervous system. Nat. Rev. Neurosci. 2008, 9:292-303.
21. Furman M., Wang X.J. Similarity effect and optimal control of multiple-choice decision making. Neuron 2008, 60:1153-1168.
22. Geisler W.S., Albrecht D.G. Bayesian analysis of identification performance in monkey visual cortex: Nonlinear mechanisms and stimulus certainty. Vision Res. 1995, 35:2723-2730.
23. Geisler W.S., Albrecht D.G., Crane A.M., Stern L. Motion direction signals in the primary visual cortex of cat and monkey. Vis. Neurosci. 2001, 18:501-516.
24. Glimcher P.W. Indeterminacy in brain and behavior. Annu. Rev. Psychol. 2005, 56:25-56.
25. Gold J.I., Shadlen M.N. The neural basis of decision making. Annu. Rev. Neurosci. 2007, 30:535-574.
26. Gottlieb J., Balan P. Attention as a decision in information space. Trends Cogn. Sci. 2010, 14:240-248.
27. Hanes D.P., Schall J.D. Neural control of voluntary movement initiation. Science 1996, 274:427-430.
28. Huk A.C., Shadlen M.N. Neural activity in macaque parietal cortex reflects temporal integration of visual motion signals during perceptual decision making. J. Neurosci. 2005, 25:10420-10436.
29. Keat J., Reinagel P., Reid R.C., Meister M. Predicting every spike: A model for the responses of visual neurons. Neuron 2001, 30:803-817.
30. Lewis J.W., Van Essen D.C. Mapping of architectonic subdivisions in the macaque monkey, with emphasis on parieto-occipital cortex. J. Comp. Neurol. 2000, 428:79-111.
31. Machens C.K., Romo R., Brody C.D. Flexible control of mutual inhibition: A neural model of two-interval discrimination. Science 2005, 307:1121-1124.
32. Maimon G., Assad J.A. Beyond Poisson: Increased spike-time regularity across primate parietal cortex. Neuron 2009, 62:426-440.
33. McAdams C.J., Maunsell J.H. Effects of attention on the reliability of individual neurons in monkey visual cortex. Neuron 1999, 23:765-773.
34. Miller P., Wang X.J. Power-law neuronal fluctuations in a recurrent network model of parametric working memory. J. Neurophysiol. 2006, 95:1099-1114.
35. Nawrot M.P., Boucsein C., Rodriguez Molina V., Riehle A., Aertsen A., Rotter S. Measurement of variability dynamics in cortical spike trains. J. Neurosci. Methods 2008, 169:374-390.
36. Parker A.J., Newsome W.T. Sense and the single neuron: Probing the physiology of perception. Annu. Rev. Neurosci. 1998, 21:227-277.
37. Ratcliff R., Rouder J.N. Modeling response times for two-choice decisions. Psychol. Sci. 1998, 9:347-356.
38. Reddi B.A., Asrress K.N., Carpenter R.H. Accuracy, information, and response time in a saccadic decision task. J. Neurophysiol. 2003, 90:3538-3546.
39. Romo R., Salinas E. Touch and go: Decision-making mechanisms in somatosensation. Annu. Rev. Neurosci. 2001, 24:107-137.
40. Shadlen M.N., Newsome W.T. The variable discharge of cortical neurons: Implications for connectivity, computation, and information coding. J. Neurosci. 1998, 18:3870-3896.
41. Smith P.L., Ratcliff R. Psychology and neurobiology of simple decisions. Trends Neurosci. 2004, 27:161-168.
42. Softky W.R., Koch C. The highly irregular firing of cortical cells is inconsistent with temporal integration of random EPSPs. J. Neurosci. 1993, 13:334-350.
43. Teich M.C., Heneghan C., Lowen S.B., Ozaki T., Kaplan E. Fractal character of the neural spike train in the visual system of the cat. J. Opt. Soc. Am. A Opt. Image Sci. Vis. 1997, 14:529-546.
44. Tolhurst D.J., Heeger D.J. Comparison of contrast-normalization and threshold models of the responses of simple cells in cat striate cortex. Vis. Neurosci. 1997, 14:293-309.
45. Tolhurst D.J., Movshon J.A., Dean A.F. The statistical reliability of signals in single neurons in cat and monkey visual cortex. Vision Res. 1983, 23:775-785.
46. Usher M., McClelland J.L. The time course of perceptual choice: The leaky, competing accumulator model. Psychol. Rev. 2001, 108:550-592.
47. Vaadia E., Haalman I., Abeles M., Bergman H., Prut Y., Slovin H., Aertsen A. Dynamics of neuronal interactions in monkey cortex in relation to behavioural events. Nature 1995, 373:515-518.
48. Wang X.J. Probabilistic decision making by slow reverberation in cortical circuits. Neuron 2002, 36:955-968.
49. Wong K.F., Huk A.C., Shadlen M.N., Wang X.J. Neural circuit dynamics underlying accumulation of time-varying evidence during perceptual decision making. Front. Comput. Neurosci. 2007, 1:6.