HPLC-APCI-MS/MS method for the determination of catalpol in rat plasma and cerebrospinal fluid: Application to an in vivo pharmacokinetic study

Journal of Pharmaceutical and Biomedical Analysis

Volumn 70, Issue , 2012, Pages 337-343

  Wang, Qin ^a,b   Xing, Mao ^c   Chen, Weihai ^a   Zhang, Jifen ^a   Qi, Hongyi ^a   Xu, Xiaoyu ^a  

^a SOUTHWEST UNIVERSITY   (China)

^b Chongqing Hospital of Traditional Chinese Medicine   (China)

^c THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Catalpol; Cerebrospinal fluid; HPLC APCI MS MS; Pharmacokinetic; Plasma

Indexed keywords

AMMONIUM ACETATE; AUCUBIN; CATALPOL; METHANOL;

ANIMAL EXPERIMENT; ARTICLE; ATMOSPHERIC PRESSURE CHEMICAL IONIZATION; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG TRANSPORT; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF QUANTITATION; MALE; MASS SPECTROMETRY; MULTIPLE REACTION MONITORING; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; QUALITY CONTROL; RAT; STANDARD; TANDEM MASS SPECTROMETRY; TRIPLE QUADRUPOLE TANDEM MASS SPECTROMETER; VALIDATION PROCESS;

ACETATES; ANIMALS; AREA UNDER CURVE; ATMOSPHERIC PRESSURE; CALIBRATION; CHEMICAL PRECIPITATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; DRUGS, CHINESE HERBAL; HALF-LIFE; INJECTIONS, INTRAVENOUS; IRIDOID GLUCOSIDES; LIMIT OF DETECTION; LINEAR MODELS; MALE; METABOLIC CLEARANCE RATE; METHANOL; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84866238472     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.05.016     Document Type: Article

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