Cerebral tissue hemoglobin saturation in children with sickle cell disease

Pediatric Blood and Cancer

Volumn 59, Issue 5, 2012, Pages 881-887

  Quinn, Charles T ^a   Dowling, Michael M ^b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Brain; Desaturation; Hypoxemia; Risk factor; Sickle cell disease; Stroke

Indexed keywords

HEMOGLOBIN; HEMOGLOBIN F; HYDROXYUREA;

ARTICLE; BLOOD FLOW VELOCITY; BLOOD GAS PARAMETERS; BLOOD TRANSFUSION; BRAIN BLOOD FLOW; BRAIN INJURY; BRAIN TISSUE; CHILD; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; FEMALE; HEMOGLOBIN DETERMINATION; HEMOGLOBIN SATURATION; HUMAN; LABORATORY TEST; MAGNETIC RESONANCE ANGIOGRAPHY; MAJOR CLINICAL STUDY; MALE; NEAR INFRARED SPECTROSCOPY; NEUROIMAGING; OCCLUSIVE CEREBROVASCULAR DISEASE; OXIMETRY; PRESCHOOL CHILD; PRIORITY JOURNAL; RETICULOCYTE; RISK ASSESSMENT; SCHOOL CHILD; SICKLE CELL ANEMIA;

ADOLESCENT; ANEMIA, SICKLE CELL; BLOOD FLOW VELOCITY; BLOOD TRANSFUSION; BRAIN; CEREBRAL ARTERIAL DISEASES; CEREBRAL INFARCTION; CEREBROVASCULAR CIRCULATION; CHILD; CONSTRICTION, PATHOLOGIC; CROSS-SECTIONAL STUDIES; FEMALE; HEMOGLOBINS; HUMANS; MALE; OXIMETRY; OXYGEN CONSUMPTION; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL;

EID: 84866184138     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.24227     Document Type: Article

References (27)

1. Kirkham FJ, Hewes DK, Prengler M, et al. Nocturnal hypoxaemia and central-nervous-system events in sickle-cell disease. Lancet 2001; 357: 1656-1659.
2. Quinn CT, Ahmad N. Clinical correlates of steady-state oxyhaemoglobin desaturation in children who have sickle cell disease. Br J Haematol 2005; 131: 129-134.
3. Quinn CT, Sargent JW. Daytime steady-state haemoglobin desaturation is a risk factor for overt stroke in children with sickle cell anaemia. Br J Haematol 2008; 140: 336-339.
4. Quinn CT, Variste J, Dowling MM. Haemoglobin oxygen saturation is a determinant of cerebral artery blood flow velocity in children with sickle cell anaemia. Br J Haematol 2009; 145: 500-505.
5. Needleman JP, Setty BN, Varlotta L, et al. Measurement of hemoglobin saturation by oxygen in children and adolescents with sickle cell disease. Pediatr Pulmonol 1999; 28: 423-428.
6. Seakins M, Gibbs WN, Milner PF, et al. Erythrocyte Hb-S concentration. An important factor in the low oxygen affinity of blood in sickle cell anemia. J Clin Invest 1973; 52: 422-432.
7. Ueda Y, Nagel RL, Bookchin RM. An increased Bohr effect in sickle cell anemia. Blood 1979; 53: 472-480.
8. Dowling MM, Quinn CT, Rogers ZR, et al. Acute silent cerebral infarction in children with sickle cell anemia. Pediatr Blood Cancer 2010; 54: 461-464.
9. Powars DR. Management of cerebral vasculopathy in children with sickle cell anaemia. Br J Haematol 2000; 108: 666-678.
10. Nur E, Kim YS, Truijen J, et al. Cerebrovascular reserve capacity is impaired in patients with sickle cell disease. Blood 2009; 114: 3473-3478.
11. Debaun MR, Derdeyn CP, McKinstry RC, III. Etiology of strokes in children with sickle cell anemia. Ment Retard Dev Disabil Res Rev 2006; 12: 192-199.
12. Nahavandi M, Tavakkoli F, Hasan SP, et al. Cerebral oximetry in patients with sickle cell disease. Eur J Clin Invest 2004; 34: 143-148.
13. Raj A, Bertolone SJ, Mangold S, et al. Assessment of cerebral tissue oxygenation in patients with sickle cell disease: Effect of transfusion therapy. J Pediatr Hematol Oncol 2004; 26: 279-283.
14. Tavakkoli F, Nahavandi M, Wyche MQ, et al. Effects of hydroxyurea treatment on cerebral oxygenation in adult patients with sickle cell disease: An open-label pilot study. Clin Ther 2005; 27: 1083-1088.
15. Raj AB, O'Brien LM, Bertolone SJ, et al. Cerebral oximetry improves detection of sickle cell patients at risk for nocturnal cerebral hypoxia. Pediatr Pulmonol 2006; 41: 1088-1094.
16. Fischer GW. Recent advances in application of cerebral oximetry in adult cardiovascular surgery. Semin Cardiothorac Vasc Anesth 2008; 12: 60-69.
17. Fischer GW, Silvay G. Cerebral oximetry in cardiac and major vascular surgery. HSR Proc Intensive Care Cardiovasc Anesth 2010; 2: 249-256.
18. Quinn CT, Rogers ZR, McCavit TL, et al. Improved survival of children and adolescents with sickle cell disease. Blood 2010; 115: 3447-3452.
19. Quinn CT, Rogers ZR, Buchanan GR. Survival of children with sickle cell disease. Blood 2004; 103: 4023-4027.
20. Ito H, Kanno I, Fukuda H. Human cerebral circulation: Positron emission tomography studies. Ann Nucl Med 2005; 19: 65-74.
21. Fenik JC, Rais-Bahrami K. Neonatal cerebral oximetry monitoring during ECMO cannulation. J Perinatol 2009; 29: 376-381.
22. MacLeod DB, Ikeda K, Vacchiano C. Absolute and Trending Accuracy of FORE-SIGHT and INVOS Cerebral Oximeters in Healthy Volunteers. Proceedings of the 2009 Annual Meeting of the American Society Anesthesiologists 2009:A298.
23. Adams RJ, McKie VC, Hsu L, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med 1998; 339: 5-11.
24. Faul F, Erdfelder E, Buchner A, et al. Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses. Behav Res Methods 2009; 41: 1149-1160.
25. Ohene-Frempong K, Weiner SJ, Sleeper LA, et al. Cerebrovascular accidents in sickle cell disease: Rates and risk factors. Blood 1998; 91: 288-294.
26. Vichinsky EP, Neumayr LD, Gold JI, et al. Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia. JAMA 2010; 303: 1823-1831.
27. Harrison JS, Rameshwar P, Chang V, et al. Oxygen saturation in the bone marrow of healthy volunteers. Blood 2002; 99: 394.