Human T-cell leukemia virus type 1 (HTLV-1) bZIP factor requires cellular transcription factor JunD to upregulate HTLV-1 antisense transcription from the 3' long terminal repeat

Journal of Virology

Volumn 86, Issue 17, 2012, Pages 9070-9078

  Gazon, Hélène ^a,c   Lemasson, Isabelle ^b   Polakowski, Nicholas ^b   Césaire, Raymond ^c   Matsuoka, Masao ^d   Barbeau, Benoit ^e   Mesnard, Jean Michel ^a   Peloponese, Jean Marie ^a  

^a University of Montpellier I and II   (France)

^b EAST CAROLINA UNIVERSITY   (United States)

^c Centre Hospitalier et Universitaire de Fort de France   (France)

^d KYOTO UNIVERSITY   (Japan)

^e UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN T CELL LEUKEMIA VIRUS TYPE 1 BASIC LEUCINE ZIPPER FACTOR; PROTEIN C JUN; TAX PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR JUNB; TRANSCRIPTION FACTOR JUND; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

3' LONG TERMINAL REPEAT; 5' LONG TERMINAL REPEAT; ANIMAL CELL; ANTISENSE TRANSCRIPTION; ARTICLE; BINDING SITE; CELL IMMORTALIZATION; CELL TRANSFORMATION; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS TYPE 1 BASIC LEUCINE ZIPPER FACTOR GENE; LONG TERMINAL REPEAT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; T CELL LEUKEMIA; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION; VIRUS GENE;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 84866163332     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00661-12     Document Type: Article

References (65)

1. Agarwal SK, et al. 2003. Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter. Proc. Natl. Acad. Sci. U. S. A. 100:10770-10775.
2. Arnold J, Zimmerman B, Li M, Lairmore MD, Green PL. 2008. Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation. Blood 112:3788-3797.
3. Arpin-Andre C, Mesnard JM. 2007. The PDZ domain-binding motif of the human T cell leukemia virus type 1 Tax protein induces mislocalization of the tumor suppressor hScrib in T cells. J. Biol. Chem. 282:33132-33141.
4. Bakiri L, Lallemand D, Bossy-Wetzel E, Yaniv M. 2000. Cell cycledependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression. EMBO J. 19:2056-2068.
5. Barbeau B, Mesnard JM. 2011. Making sense out of antisense transcription in human T-cell lymphotropic viruses (HTLVs). Viruses 3:456-468.
6. Barnhart MK, Connor LM, Marriott SJ. 1997. Function of the human T-cell leukemia virus type 1 21-base-pair repeats in basal transcription. J. Virol. 71:337-344.
7. Basbous J, et al. 2003. The HBZ factor of human T-cell leukemia virus type I dimerizes with transcription factors JunB and c-Jun and modulates their transcriptional activity. J. Biol. Chem. 278:43620-43627.
8. Belrose G, et al. 2011. Effects of valproate on Tax and HBZ expression in HTLV-1 and HAM/TSP T lymphocytes. Blood 118:2483-2491.
9. Berger I, Shaul Y. 1998. c-Fos antagonizes the junD gene positive autoregulatory loop; a novel c-Fos role in promoter switching. Gene 211:375-382.
10. Calomme C, et al. 2004. Overlapping CRE and E box motifs in the enhancer sequences of the bovine leukemia virus 5' long terminal repeat are critical for basal and acetylation-dependent transcriptional activity of the viral promoter: implications for viral latency. J. Virol. 78:13848-13864.
11. Cavanagh M-H, et al. 2006. HTLV-1 antisense transcripts initiating in the 3'LTR are alternatively spliced and polyadenylated. Retrovirology 3:15.
12. Clerc I, et al. 2008. An interaction between the human T cell leukemia virus type 1 basic leucine zipper factor (HBZ) and the KIX domain of p300/CBP contributes to the downregulation of tax-dependent viral transcription by HBZ. J. Biol. Chem. 283:23903-23913.
13. Cook PR, Polakowski N, Lemasson I. 2011. HTLV-1 HBZ protein deregulates interactions between cellular factors and the KIX domain of p300/CBP. J. Mol. Biol. 409:384-398.
14. Deniaud E, et al. 2009. Overexpression of transcription factor Sp1 leads to gene expression perturbations and cell cycle inhibition. PLoS One 4:e7035. doi:10.1371/journal.pone.0007035.
15. Eferl R, Wagner EF. 2003. AP-1: a double-edged sword in tumorigenesis. Nat. Rev. Cancer 3:859-868.
16. Fujii M, et al. 2000. Activation of oncogenic transcription factor AP-1 in T cells infected with human T cell leukemia virus type 1. AIDS Res. Hum. Retrovir. 16:1603-1606.
17. Gaudray G, et al. 2002. The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that downregulates viral transcription. J. Virol. 76:12813-12822.
18. Gerald D, et al. 2004. JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell 118:781-794.
19. Giam CZ, Jeang KT. 2007. HTLV-1 Tax and adult T-cell leukemia. Front. Biosci. 12:1496-1507.
20. Hai T, Curran T. 1991. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc. Natl. Acad. Sci. U. S. A. 88:3720-3724.
21. Hirai SI, Ryseck RP, Mechta F, Bravo R, Yaniv M. 1989. Characterization of junD: a new member of the jun proto-oncogene family. EMBO J. 8:1433-1439.
22. Hivin P, Arpin-Andre C, Clerc I, Barbeau B, Mesnard JM. 2006. A modified version of a Fos-associated cluster in HBZ affects Jun transcriptional potency. Nucleic Acids Res. 34:2761-2772.
23. Iha H, et al. 2000. Pleiotropic effects of HTLV type 1 Tax protein on cellular metabolism: mitotic checkpoint abrogation and NF-κB activation. AIDS Res. Hum. Retrovir. 16:1633-1638.
24. Indran IR, Hande MP, Pervaiz S. 2011. hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells. Cancer Res. 71:266-276.
25. Isono O, et al. 2008. Human T-cell leukemia virus type 1 HBZ protein bypasses the targeting function of ubiquitination. J. Biol. Chem. 283:34273-34282.
26. Jin DY, Spencer F, Jeang KT. 1998. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell 93:81-91.
27. Kardassis D, Papakosta P, Pardali K, Moustakas A. 1999. c-Jun transactivates the promoter of the human p21WAF1/Cip1 gene by acting as a superactivator of the ubiquitous transcription factor Sp1. J. Biol. Chem. 274:29572-29581.
28. Koiwa T, et al. 2002. 5'-long terminal repeat-selective CpG methylation of latent human T-cell leukemia virus type 1 provirus in vitro and in vivo. J. Virol. 76:9389-9397.
29. Kuhlmann AS, et al. 2007. HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT). Retrovirology 4:92.
30. Landry S, et al. 2009. Upregulation of human T-cell leukemia virus type 1 antisense transcription by the viral tax protein. J. Virol. 83:2048-2054.
31. Lemasson I, et al. 2007. Human T-cell leukemia virus type 1 (HTLV-1) bZIP protein interacts with the cellular transcription factor CREB to inhibit HTLV-1 transcription. J. Virol. 81:1543-1553.
32. Matsuoka M, Green PL. 2009. The HBZ gene, a key player in HTLV-1 pathogenesis. Retrovirology 6:71.
33. Matsuoka M, Jeang KT. 2010. Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ, and therapy. Oncogene 30:1379-1389.
34. Mechta-Grigoriou F, Gerald D, Yaniv M. 2001. The mammalian Jun proteins: redundancy and specificity. Oncogene 20:2378-2389.
35. Merezak C, et al. 2001. Suboptimal enhancer sequences are required for efficient bovine leukemia virus propagation in vivo: implications for viral latency. J. Virol. 75:6977-6988.
36. Mesnard JM, Barbeau B, Devaux C. 2006. HBZ, a new important player in the mystery of adult T-cell leukemia. Blood 108:3979-3982.
37. Miyazaki M, et al. 2007. Preferential selection of human T-cell leukemia virus type 1 provirus lacking the 5' long terminal repeat during oncogenesis. J. Virol. 81:5714-5723.
38. Miyazato A, Sheleg S, Iha H, Li Y, Jeang KT. 2005. Evidence for NF-κB-and CBP-independent repression of p53's transcriptional activity by human T-cell leukemia virus type 1 Tax in mouse embryo and primary human fibroblasts. J. Virol. 79:9346-9350.
39. Mori N, et al. 2000. Constitutive activation of transcription factor AP-1 in primary adult T-cell leukemia cells. Blood 95:3915-3921.
40. Murata K, et al. 2006. A novel alternative splicing isoform of human T-cell leukemia virus type 1 bZIP factor (HBZ-SI) targets distinct subnuclear localization. J. Virol. 80:2495-2505.
41. Peloponese JM, Jr, Kinjo T, Jeang KT. 2007. Human T-cell leukemia virus type 1 Tax and cellular transformation. Int. J. Hematol. 86:101-106.
42. Peloponese JM, Yeung ML, Jeang KT. 2006. Modulation of nuclear factor-κB by human T cell leukemia virus type 1 Tax protein: implications for oncogenesis and inflammation. Immunol. Res. 34:1-12.
43. Pfarr CM, et al. 1994. Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras. Cell 76:747-760.
44. Risser R, Pollack R. 1974. A nonselective analysis of SV40 transformation of mouse 3T3 cells. Virology 59:477-489.
45. Ryder K, Lanahan A, Perez-Albuerne E, Nathans D. 1989. junD: a third member of the jun gene family. Proc. Natl. Acad. Sci. U. S. A. 86:1500-1503.
46. Saito M, et al. 2009. In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Retrovirology 6:19.
47. Sato H, et al. 2010. Multi-step aberrant CpG island hypermethylation is associated with the progression of adult T-cell leukemia/lymphoma. Am. J. Pathol. 176:402-415.
48. Satou Y, Yasunaga J, Yoshida M, Matsuoka M. 2006. HTLV-1 basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Proc. Natl. Acad. Sci. U. S. A. 103:720-725.
49. Shaulian E. 2010. AP-1-the Jun proteins: oncogenes or tumor suppressors in disguise? Cell Signal 22:894-899.
50. Shaulian E, Karin M. 2002. AP-1 as a regulator of cell life and death. Nat. Cell Biol. 4:E131-E136.
51. Shaywitz AJ, Greenberg ME. 1999. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu. Rev. Biochem. 68:821-861.
52. Sheleg SV, et al. 2007. Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 Tax. J. Virol. 81:7894-7901.
53. Tabakin-Fix Y, Azran I, Schavinky-Khrapunsky Y, Levy O, Aboud M. 2006. Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications. Carcinogenesis 27:673-681.
54. Takeda S, et al. 2004. Genetic and epigenetic inactivation of tax gene in adult T-cell leukemia cells. Int. J. Cancer 109:559-567.
55. Tamiya S, et al. 1996. Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia. Blood 88:3065-3073.
56. Taniguchi Y, et al. 2005. Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms. Retrovirology 2:64.
57. Thebault S, Basbous J, Hivin P, Devaux C, Mesnard JM. 2004. HBZ interacts with JunD and stimulates its transcriptional activity. FEBS Lett. 562:165-170.
58. Uchida N, et al. 1999. Correlation of telomerase activity with development and progression of adult T-cell leukemia. Leuk. Res. 23:311-316.
59. Vesely PW, Staber PB, Hoefler G, Kenner L. 2009. Translational regulation mechanisms of AP-1 proteins. Mutat. Res./Rev. Mutat. Res. 682:7-12.
60. Weitzman JB, Fiette L, Matsuo K, Yaniv M. 2000. JunD protects cells from p53-dependent senescence and apoptosis. Mol. Cell 6:1109-1119.
61. Wessner R, Wigdahl B. 1997. AP-1 derived from mature monocytes and astrocytes preferentially interacts with the HTLV-1 promoter central 21-bp repeat. Leukemia 11(Suppl 3):21-24.
62. Wisdom R, Johnson RS, Moore C. 1999. c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. EMBO J. 18:188-197.
63. Wu Y, Zhang X, Zehner ZE. 2003. c-Jun and the dominant-negative mutant, TAM67, induce vimentin gene expression by interacting with the activator Sp1. Oncogene 22:8891-8901.
64. Yasunaga J, Matsuoka M. 2011. Molecular mechanisms of HTLV-1 infection and pathogenesis. Int. J. Hematol. 94:435-442.
65. Yoshida M, Satou Y, Yasunaga J, Fujisawa J, Matsuoka M. 2008. Transcriptional control of spliced and unspliced human T-cell leukemia virus type 1 bZIP factor (HBZ) gene. J. Virol. 82:9359-9368.