Affinity for, and localization of, PEG-functionalized silica nanoparticles to sites of damage in an ex vivo spinal cord injury model

Journal of Biological Engineering

Volumn 6, Issue , 2012, Pages

  Chen, Bojun ^a   Zuberi, Mahvash ^a   Borgens, Richard Ben ^a,b   Cho, Youngnam ^a,c  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c National Cancer Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

MACROGOL; NANOPARTICLE; SILICA NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; EX VIVO STUDY; IN VIVO STUDY; MEMBRANE DAMAGE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY;

CAVIA; RATTUS;

EID: 84866158088     PISSN: None     EISSN: 17541611     Source Type: Journal    
DOI: 10.1186/1754-1611-6-18     Document Type: Article

References (57)

1. McNally HA, Borgens RB. Three-Dimensional Imaging of Living and Dying Neurons with Atomic Force Microscopy. J Neurocytol 2004, 33:251-258.
2. Schwab JM, Leppert CA, Kaps K, Monnier PP. Functional recovery after spinal cord injury: basic science meets clinic. Trends Neurosci 2001, 24:437-439. 10.1016/S0166-2236(00)01893-2, 11488296.
3. Schwab M. Repairing the Injured Spinal Cord. Scienc 2002, 295:1029-1031.
4. Borgens RB. Cellular engineering: molecular repair of membranes to rescue cells of the damaged nervous system. Neurosurgery 2001, 49:370-378. discussion 378-379.
5. Borgens RB, Shi R. Immediate recovery from spinal cord injury through molecular repair of nerve membranes with polyethylene glycol. FASEB J 2000, 14:27-35.
6. Bradbury E, McMahon S. Spinal cord repair strategies: why do they work?. Nature Rev Neurosci 2006, 7:644-653.
7. Keirstead HS, Nistor G, Bernal G, Totoiu M, Cloutier F, Sharp K, Steward O. Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Remyelinate and Restore Locomotion after Spinal Cord Injury J Neurosci 2005, 29:4694-4705.
8. Coutts M, Keirstead HS. Stem cells for the treatment of spinal cord injury. Exp Neurol 2008, 209:368-377. 10.1016/j.expneurol.2007.09.002, 17950280.
9. Borgens R, Shi R, Bohnert D. Behavioral Recovery From Spinal Cord Injury Following Delayed Application of Polyethylene Glycol. J Exp Biology 2002, 205:1-12.
10. Luo J, Borgens R, Shi R. Polyethylene glycol improves function and reduces oxidative stress in synaptosomes following spinal cord injury. J Neurotrauma 2004, 21:994-1007. 10.1089/0897715041651097, 15318999.
11. Serbest G, Horwitz J, Jost M, Barbee K. Mechanisms of cell death and neuroprotection by poloxamer 188 after mechanical trauma. FASEB J 2006, 20:308-310.
12. Cadichon SB, Le H, Wright D, Curry D, Kang U, Frim DM. Neuroprotective effect of the surfactant poloxamer 188 in a model of intracranial hemorrhage in rats. J Neurosurg 2007, 106:36-40. 10.3171/jns.2007.106.1.36, 17240554.
13. Koob AO, Borgens RB. Polyethylene glycol treatment after traumatic brain injury reduces beta-amyloid precursor protein accumulation in degenerating axons. J Neurosci Res 2006, 83:1558-1563. 10.1002/jnr.20837, 16555285.
14. Koob AO, Duerstock BS, Babbs CF, Sun Y, Borgens RB. Intravenous polyethylene glycol inhibits the loss of cerebral cells after brain injury. J Neurotrauma 2005, 22:1092-1111. 10.1089/neu.2005.22.1092, 16238486.
15. Laverty PH, Leskovar A, Breur GJ, Coates JR, Bergman RL, Widmer WR, Toombs JP, Shapiro S, Borgens RB. A preliminary study of intravenous surfactants in paraplegic dogs: polymer therapy in canine clinical SCI. J Neurotrauma 2004, 21:1767-1777. 10.1089/neu.2004.21.1767, 15684768.
16. Lee RC, River LP, Pan F, Wollman RS. Surfactant-induced sealing of electrpermeabilized skeletal muscle membranes in vitro. Proc Natl Acad Sci USA 1992, 89:4524-4528. 10.1073/pnas.89.10.4524, 49115, 1584787.
17. Merchant FA, Holmes WH, Capelli-schellpfeffer BS, Lee RC, Toner M. Poloxamer 188 enhances functional recovery of lethally heat-shocked fibroblasts. J Surgical Research 1998, 74:131-140.
18. Palmer JS, Cromie WJ, Lee RC. Surfactant administration reduces testicular ischemia-reperfusion injury. J Urol 1998, 159:2136-2139. 10.1016/S0022-5347(01)63295-6, 9598559.
19. Borgens RB, Bohnert D, Duerstock B, Spomar D, Lee RC. Subcutaneous tri-block copolymer produces recovery from spinal cord injury. J Neurosci Res 2004, 76:141-154. 10.1002/jnr.20053, 15048938.
20. Quinlan JG, Wong BL, Niemeier RT, McCullough AS, Levin L, Emanuele M. Poloxamer 188 failed to prevent exercise-induced membrane breakdown in mdx skeletal muscle fibers. Neuromuscul Disord 2006, 16:855-864. 10.1016/j.nmd.2006.09.016, 17118658.
21. Shi Y, Kim S, Huff TB, Borgens RB, Park K, Shi R, Cheng JX. Effective repair of traumatically injured spinal cord by nanoscale block copolymer micelles. Nat Nanotechnol 2009, 5:80-87. 2843695, 19898498.
22. Borgens RB, Bohnert D. Rapid recovery from spinal cord injury following subcutaneously administered polyethylene glycol. J Neurosci Res 2001, 66:1179-1186. 10.1002/jnr.1254, 11746451.
23. Donaldson J, Shi R, Borgens R. Polyethylene glycol rapidly restores physiological functions in damaged sciatic nerves of guinea pigs. Neurosurgery 2002, 50:147-156.
24. Koob AO, Colby JM, Borgens RB. Behavioral recovery from traumatic brain injury after membrane reconstruction using polyethylene glycol. J Biol Eng 2008, 2:9. 10.1186/1754-1611-2-9, 2474576, 18588669.
25. Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC. Effects of polyethylene glycol and magnesium sulfate administration on clinically relevant neurological outcomes after spinal cord injury in the rat. J Neurosci Res 2007, 85:1458-1467. 10.1002/jnr.21283, 17410603.
26. Detlof MR, Lavik E, Fisher LC, Langer R, Basso DM. Polyethylene Glycol Administration After Moderate Spinal Cord Injury Decreases Lesion Size and Improves Locomotor Recover. J Neurol Phys Ther 2006, 30:201. 210.1097/1001.NPT.0000281275.0000295819.cd.
27. Detloff MR, Lavik E, Fisher LC, Langer R, Basso DM. Polyethylene glycol administration after moderate spinal cord injury decreases lesionsize and improves locomotor recovery. J Neurotrauma 2005, 22:1219.
28. Schneiderman S, Farber JL, Baserga R. A simple method for decreasing the toxicity of polyethylene glycol in mammalian cell hybridization. Somat Cell Mol Genet 1979, 5:263-269.
29. Szabó G, Kiss A, Trón L. Permeabilization of lymphocytes with polyethylene glycol 1000. Discrimination of permeabilized cells by flow cytometry. Cytometry 1982, 3:59-63.
30. Cole A, Shi R. Prolonged focal application of polyethylene glycol induces conduction block in guinea pig spinal cord white matter. Toxicol Vitr 2005, 19:215-220.
31. Webster R, Elliott V, Park BK, Walker D, Hankin M, Taupin P. PEG and PEG conjugates toxicity: towards an understanding of the toxicity of PEG and its relevance to PEGylated biologicals. PEGylated Protein Drugs: Basic Science and Clinical Application 2009, 127-146. Switzerland: Birkhäuser Basel, Veronese FM, Milestones in Drug Therapy.
32. Brent J. Current management of ethylene glycol poisoning. Drugs 2001, 61:979-988. 10.2165/00003495-200161070-00006, 11434452.
33. Caravati EM, Erdman AR, Christianson G, Manoguerra AS, Booze LL, Woolf AD, Olson KR, Chyka PA, Scharman EJ, Wax PM, et al. Ethylene glycol exposure: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila) 2005, 43:327-345.
34. Cho Y, Shi R, Borgens R, Ivanisevic A. Repairing the Damaged Spinal Cord and Brain with Nanomedicine. Small 2008, 4:1676-1681. 10.1002/smll.200800838, 18798208.
35. Cho Y, Shi R, Borgens RB. Chitosan nanoparticle-based neuronal membrane sealing and neuroprotection following acrolein-induced cell injury. J Bio Eng 2010, 29:2.
36. Cho Y, Shi R, Ivanisevic A, Borgens RB. The Functionalized Mesoporous Silica Nanoparticles (MSNs) Based Drug Delivery System to Rescue Acrolein-Mediated Cell Death. Nanomedicine 2008, 3:507-519. 10.2217/17435889.3.4.507, 18694313.
37. Cho Y, Shi R, Ivanisevic A, Borgens RB. Functional Silica Nanoparticle-Mediated Neuronal Membrane Sealing Following Traumatic Spinal Cord Injury. J Neurosci Res 2010, 88:1433-1444. 10.1002/jnr.22309, 19998478.
38. Mohanraj VJ, Chen Y. Nanoparticles - A Review. Trop J Pharm Res 2006, 5:561-573.
39. Liu-Snyder P, Logan M, Shi R, Smith D, Borgens R. Neuroprotection from secondary injury by polyethylene glycol requires its internalization. J Exp Biol 2007, 210:1-8. 10.1242/jeb.02588, 17170143.
40. Liu-Snyder P, Logan MP, Shi R, Smith DT, Borgens RB. Neuroprotection from secondary injury by polyethylene glycol requires its internalization. J Exp Biol 2007, 210:1455-1462. 10.1242/jeb.02756, 17401128.
41. Cho Y, Borgens RB. Polymer and nano-technology applications for repair and reconstruction of the central nervous system. Exp Neurol 2012, 233:126-144. 10.1016/j.expneurol.2011.09.028, 21985867.
42. Borgens RB, Liu-Snyder P. Understanding Secondary Injury. The Quarterly Review Of Biology 2012, 87:89-127. 10.1086/665457, 22696939.
43. Bittner GD, Ballinger ML, Raymond MA. Reconnection of severed nerve axons with polyethylene glycol. Brain Res 1986, 367:351-355. 10.1016/0006-8993(86)91617-3, 3697710.
44. Lee RC. Cytoprotection by Stabilization of Cell Membranes. Annals New Your Academy of Sciences 2002, 961:271-275.
45. Lentz B. PEG as a tool to gain insight into membrane fusion. Eur Biophys J 2007, 36:315-326. 10.1007/s00249-006-0097-z, 17039359.
46. MacDonald RI. Membrane fusion due to dehydration by polyethylene glycol, dextran, or sucrose. Biochemistry 1985, 24:4058-4066. 10.1021/bi00336a039, 2413883.
47. Weinreb G, Lentz BR. Analysis of membrane fusion as a two-state sequential process: evaluation of the stalk model. Biophys J 2007, 92:4012-4029. 10.1529/biophysj.106.090043, 1869000, 17369418.
48. Borgens RB, Jaffe LF, Cohen MJ. Large and persistent electrical currents enter the transected lamprey spinal cord. Proc Natl Acad Sci U S A 1980, 77:1209-1213. 10.1073/pnas.77.2.1209, 348455, 6928670.
49. Borgens RB. Artificially controlling axonal regeneration and development by applied electric fields 1989, 117-170. New York: Alan R. Liss, Electric Fields in Vertebrate Repair.
50. Zuberi M, Liu-Snyder P, Ul Haque A, Porterfield DM, Borgens RB. Large naturally-produced electric currents and voltage traverse damaged mammalian spinal cord. J Biol Eng 2008, 2:17. 10.1186/1754-1611-2-17, 2647896, 19116024.
51. Cho Y, Shi R, Borgens RB. Chitosan produces potent neuroprotection and physiological recovery following traumatic spinal cord injury. J Exp Biol 2010, 213:1513-1520. 10.1242/jeb.035162, 20400636.
52. Fang N, Chan V. Chitosan-induced restructuration of a mica-supported phospholipid bilayer: an atomic force microscopy study. Biomacromolecules 2003, 4:1596-1604. 10.1021/bm034259w, 14606885.
53. Fang N, Chan V, Mao HQ, Leong KW. Interactions of phospholipid bilayer with chitosan: effect of molecular weight and pH. Biomacromolecules 2001, 2:1161-1168. 10.1021/bm015548s, 11777388.
54. Koob A, Duerstock B, Babbs C, Sun Y, Borgens R. Intravenous polyethylene glycol inhibits the loss of cerebral cells after brain injury. J Neurotrauma 2005, 22:1092-1111. 10.1089/neu.2005.22.1092, 16238486.
55. Koob A, Borgens R. Polyethylene Glycol Treatment After Traumatic Brain Injury Reduces Amyloid Precursor Protein Accumulation in Degenerating Axons. J Neurosci Res 2006, 83:1558-1563. 10.1002/jnr.20837, 16555285.
56. Shi R, Borgens RB. Anatomical repair of nerve membranes in crushed mammalian spinal cord with polyethylene glycol. J Neurocytol 2000, 29:633-643. 10.1023/A:1010879219775, 11353287.
57. Luo J, Borgens RB, Shi R. Polyethylene glycol immediately repairs neuronal membranes and inhibits free radical production after acute spinal cord injury. J Neurochemistry 2002, 83:471-480.