Immediate recovery from spinal cord injury through molecular repair of nerve membranes with polyethylene glycol

FASEB Journal

Volumn 14, Issue 1, 2000, Pages 27-35

  Borgens, Richard B ^a   Shi, Riyi ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Nerve fusion; Nerve repair; Neurotrauma

Indexed keywords

MACROGOL;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GUINEA PIG; NERVE CONDUCTION; NERVE MEMBRANE; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD INJURY;

ANIMALIA; CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0033982928     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.14.1.27     Document Type: Article

References (39)

1. Honmou, O., and Young, W. (1995) Traumatic injury of spinal axons. In The Axon (Waxman, S. G., Kocsis, J., and Stys, P., eds) pp. 480-529, Oxford University Press, New York
2. Griffin, J. W., George, E. B., Hsieh, S. T., and Glass, J. D. (1995) Axonal degeneration and disorders of the axonal cytoskeleton. In The Axon (Waxman, S. G., Kocsis, J., and Stys, P., eds) pp. 375-390, Oxford University Press, New York
3. Young, W. (1993) Secondary injury mechanisms in acute spinal cord injury. J. Emerg. Med. 11, 13-22
4. Maxwell, W. L., McCreath, B. L., Graham, D. I., and Gennarelli, T. A. (1995) Cytochemical evidence for redistribution of membrane pump calcium-ATPase and ecto-Ca-ATPase activity, and calcium influx in myelinated nerve fibers of the optic nerve after stretch injury. J. Neurocytol. 24, 925-942
5. Maxwell, W. L., Kosanlavit, R., McCreath, B. J., Reid, O., and Graham, D. I. (1999) Freeze-fracture and cytochemical evidence for structural and functional alteration in the axolemma and myelin sheath of adult guinea pig optic nerve fibers after stretch injury. J. Neurotrauma 16, 273-284
6. Shi, R., Asano, T., Vining, N. C., and Blight, A. R. (1997) Calpain dependence of membrane sealing in mammalian spinal cord axons. Soc. Neurosci. Abstr. 108, 16
7. Hannig, J., Yu, J., Beckett, M., Weichselbaum, R., and Lee, R. C. (1999) Poloxamine 1107 sealing of radiopermeabilized erythrocyte membranes. Int. J. Radiat. Biol. 75, 379-385
8. Padanlam, J. T., Bischof, J. C., Cravalho, E. G., Tompkins, R. G., Yarmush, M. L., and Toner, M. (1994) Effectiveness of Poloxamer 188 in arresting calcein leakage from thermally damaged isolated skeletal muscle cells. Ann N.Y. Acad. Sci. 92, 111-123
9. Pontecorvo, G. (1975) Production of mammalian somatic cell hybrids by means of polyethylene glycol treatment. Somatic Cell Genet. 1, 397-400
10. Davidson, R. L., O'Malley, K. A., and Wheeler, T. B. (1976) Induction of mammalian somatic cell hybridization by polyethylene glycol. Somat. Cell Genet. 2, 271-280
11. O'lague P. H., and Huttner, S. L. (1980) Physiological and morphological studies of rat phechromocytoma calls (PC12) chemically fused and grown in culture. Proc. Natl. Acad. Sci. USA 77, 1701-1705
12. Ahkong, Q. F., Desmazes, J. P., Georgescauld, D., and Lucy, J. A. (1987) Movements of fluorescent probes in the mechanism of cell fusion induced by polyethylene glycol. J. Cell Sci. 88, 389-98
13. Asano, T., Shi, R., and Blight, A. R. (1995) Horseradish peroxidase used to examine the distribution of axonal damage in spinal cord compression injury in vitro. J. Neurotrauma 12, 993
14. Shi, R., Borgens, R., and Blight, A. (1999) Functional reconnection of severed mammalian spinal cord axons with polyethylene glycol. J. Neurotrauma 16, 727-738
15. Shi, R., and Borgens, R. B. (1999) Acute repair of crushed guinea pig spinal cord by polyethylene glycol. J. Neurophysiol. 81, 2406-2414
16. Borgens, R. B., Blight, A. R., and Murphy, D. J. (1986) Axonal regeneration in spinal cord injury: a perspective and new technique. J. Comp. Neurol. 250, 157-167
17. Borgens, R. B., Blight, A. R., and McGinnis, M. E. (1990) Functional recovery after spinal cord hemisection in guinea pigs: the effects of applied electric fields. J. Comp. Neurol. 296, 634-653
18. Blight, A. R. (1991) Morphometric analysis of a model of spinal cord injury in guinea pigs, with behavioral evidence of delayed secondary pathology. J. Neurol. Sci. 103, 156-171
19. Blight, A. R., McGinnis, M. E., and Borgens, R. B. (1990) Cutaneous trunci muscle reflex of the guinea pig. J. Comp. Neurol. 60, 446
20. Thierault, E., and Diamond, J. (1988) Noceptive cutaneous stimuli evoke localized contractions in a skeletal muscle. J. Neurophys. 60, 446-447
21. Borgens, R. B., Blight, A. R., and McGinnis, M. E. (1987) Behavioral recovery induced by applied electric fields after spinal cord hemisection in guinea pig. Science. 238, 366-369
22. Lentz, B. R. (1994) Induced membrane fusion; potential mechanism and relation to cell fusion events. Chem. Physiol. Lipids 73, 91-106
23. Lee, J., and Lentz, B. R. (1997) Evolution of lipid structures during model membrane fusion and the relation of this process to cell membrane fusion. Biochemistry. 36, 6251-6259
24. Massenburg, D., and Lentz, B. R. (1993) Poly(ethylene glycol)-induced and rupture of dipalmitoylphosphatidylcholine large, unilamellar extruded vesicles. Biochemistry 32, 9172-9180
25. Tilcock, C. P. S., and Fisher, D. (1979) The interaction of phospholipid membranes with poly(ethylene glycol) vesicle aggregation and lipid exchange. Biochemistry 688, 645-652
26. Aldewinckel, T. L., Ahkong, Q. F., Bangham, A. D., Fisher, D., and Lucy, J. A. (1982) Effects of poly(ethylene glycol) on liposomes and erythrocytes: permeability changes and membrane fusion. Biochim. Biophys. Acta 689, 548-560
27. Lee, R. C., River, L. P., Pan, F.-s., Ji, L., and Wollman, R. S. (1992) Surfactant-induced sealing of eletropermeabilized skeletal muscle membranes in vitro. Proc. Natl. Acad. Sci. USA 89, 4524-4528
28. Lee, R. C., Canaday, D. J., and Hammer, S. M. (1992) Transient and stable ionic permeabilization of isolated skeletal muscle cells after electrical shock. J. Burn Care Rehab. 14, 528-540
29. Merchant, F. A., Holmes, W. H., Capelli-Schellpfeffer, B. S., Lee, R. C., and Toner, M. (1998) Poloxamer 188 enhances functional recovery of lethally heat-shocked fibroblasts. J. Surg. Res. 74, 131-140
30. Palmer, J. S., Cromie, W. J., and Lee, R. C. (1998) Surfactant administration reduces testicular ischemia-reprefusion injury. J. Urol. 159, 2136-2139
31. Blight, A. R. (1993) Remyelination, revascularization, and recovery of function in experimental spinal cord injury. In Advances in Neurobiology: Neural Injury and Regeneration (Seil, F. J., ed) Vol. 59, pp. 91-103
32. Blight, A. R. (1985) Delayed demyelination and macrophage invasion: a candidate for secondary cell damage in spinal cord injury. Central Nervous System Trauma 2, 299-315
33. Moriarty L. J., Duerstock B. S., Bajaj C. L., Lin K., and Borgens, R. B. (1998) Two and three dimensional computer graphic evaluation of the subacute spinal cord injury. J. Neurol. Sci. 155, 121-137
34. Yawo, H., and Kuno, M.,. (1985) Calcium dependence of membrane sealing at the cut end of the cockroach giant axon. J. Neurosci. 5, 1626-1632
35. Fehlings, M., and Tator, C. (1995) The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury. Exp. Neurol. 132, 123-134
36. Cheng, H., Almström, S., Giménex-Llort, L., Chang, R., Ogren, S., Hoffer, B., and Olson, L. (1997) Gait analysis of adult paraplegic rats after spinal cord injury. Exp. Neurol. 148, 544-557
37. Borgens, R. B. (1992) Applied voltages in spinal cord reconstruction: history, strategies, and behavioral models. In Spinal Cord Dysfunction: Functional Stimulation (Illis, L. S., ed) Vol. III, pp. 110-145, Oxford Medical Publications, Oxford, England
38. Borgens, R. B., Toombs, J. P., Blight, A. R., McGinnis, M. E., Bauer, M. S., Widmer, W. R., and Cook, J. R., Jr. (1993) Effects of applied electric fields on clinical cases of complete paraplegia in dogs. J. Restorative Neurol. Neurosci. 5, 305-322
39. Borgens, R. B., Toombs, J. P., Breur, G., Widmer, W. R., Water, D., Harbath, A. M., March, P., and Adams, L. G. (1999) An imposed oscillating electrical field improves the recovery of function in neurologically complete paraplegic dogs. J. Neurotrama 16, 639-657