Phosphate starvation promotes swarming motility and cytotoxicity of Pseudomonas aeruginosa

Applied and Environmental Microbiology

Volumn 78, Issue 18, 2012, Pages 6762-6768

  Bains, Manjeet ^a   Fernández, Lucía ^a   Hancock, Robert E W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATE STARVATION; PSEUDOMONAS AERUGINOSA; QUORUM-SENSING; TRANSCRIPTIONAL CHANGES; TRANSCRIPTIONAL RESPONSE;

BIOCHEMISTRY; GENES;

BACTERIA;

BACTERIAL TOXIN; PHOSPHATE;

BACTERIUM; CHEMOTAXIS; MOTILITY; PHOSPHATE; SECRETION; STARVATION; SWARMING; TOXICITY;

ARTICLE; BIOSYNTHESIS; GENE EXPRESSION PROFILING; GENETICS; LOCOMOTION; METABOLISM; PATHOGENICITY; PHYSIOLOGY; PSEUDOMONAS AERUGINOSA;

BACTERIAL TOXINS; GENE EXPRESSION PROFILING; LOCOMOTION; PHOSPHATES; PSEUDOMONAS AERUGINOSA;

PSEUDOMONAS AERUGINOSA;

EID: 84866151590     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.01015-12     Document Type: Article

References (34)

1. Anba J, Bidaud M, Vasil ML, Lazdunski A. 1990. Nucleotide sequence of the Pseudomonas aeruginosa phoB gene, the regulatory gene for the phosphate regulon. J. Bacteriol. 172:4685-4689.
2. Aoyama T, Takanami M, Makino K, Oka A. 1991. Cross-talk between the virulence and phosphate regulons of Agrobacterium tumefaciens caused by an unusual interaction of the transcriptional activator with a regulatory DNA element. Mol. Gen. Genet. 227:385-390.
3. Breidenstein EBM, de la Fuente-Núñez C, Hancock REW. 2011. Pseudomonas aeruginosa: all roads lead to resistance. Trends Microbiol. 19:419-426.
4. Chugani S, Greenberg EP. 2007. The influence of human respiratory epithelia on Pseudomonas aeruginosa gene expression. Microb. Pathog. 42:29-35.
5. Déziel E, Lépine F, Milot S, Villemur R. 2003. rhlA is required for the production of a novel biosurfactant promoting swarming motility in Pseudomonas aeruginosa: 3-(3-hydroxyalkanoyloxy)alkanoic acids (HAAs), the precursors of rhamnolipids. Microbiology 149:2005-2013.
6. Fernández L, Breidenstein EBM, Hancock REW. 2011. Creeping baselines and adaptive resistance to antibiotics. Drug Resist. Updat. 14:1-21.
7. Filloux A, Bally M, Soscia C, Murgier M, Lazdunski A. 1988. Phosphate regulation in Pseudomonas aeruginosa: cloning of the alkaline phosphatase gene and identification of phoB- and phoR-like genes. Mol. Gen. Genet. 212:510-513.
8. Frisk A, et al. 2004. Transcriptome analysis of Pseudomonas aeruginosa after interaction with human airway epithelial cells. Infect. Immun. 72:5433-5438.
9. Gooderham WJ, et al. 2009. The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa. Microbiology 155:699-711.
10. Haddad A, Jensen V, Becker T, Häussler S. 2009. The Pho regulon influences biofilm formation and type three secretion in Pseudomonas aeruginosa. Environ. Microbiol. Rep. 1:488-494.
11. Hancock REW, Poole K, Benz R. 1982. Outer membrane protein P of Pseudomonas aeruginosa: regulation by phosphate deficiency and formation of small anion-specific channels in lipid bilayer membranes. J. Bacteriol. 150:730-738.
12. Høiby N, Ciofu O, Bjarnsholt T. 2010. Pseudomonas aeruginosa biofilms in cystic fibrosis. Future Microbiol. 5:1663-1674.
13. Hsieh YJ, Wanner BL. 2010. Global regulation by the seven-component Pi signaling system. Curr. Opin. Microbiol. 13:198-203.
14. Jacobs MA, et al. 2003. Comprehensive transposon mutant library of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U. S. A. 100:14339-14344.
15. Jensen V, et al. 2006. RhlR expression in Pseudomonas aeruginosa is modulated by the Pseudomonas quinolone signal via PhoB-dependent and -independent pathways. J. Bacteriol. 188:8601-8606.
16. Lewenza S, et al. 2005. Construction of a mini-Tn5-luxCDABE mutant library in Pseudomonas aeruginosa PAO1: a tool for identifying differentially regulated genes. Genome Res. 15:583-589.
17. Long J, Zaborina O, Holbrook C, Zaborin A, Alverdy J. 2008. Depletion of intestinal phosphate after operative injury activates the virulence of Pseudomonas aeruginosa causing lethal gut-derived sepsis. Surgery 144:189-197.
18. Lyczak JB, Cannon CL, Pier GB. 2000. Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist. Microbes Infect. 2:1051-1060.
19. 2+-induced gene regulation in Pseudomonas aeruginosa. J. Bacteriol. 188:3995-4006.
20. Mougous JD, et al. 2006. A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science 312:1526-1530.
21. Mulcahy H, Charron-Mazenod L, Lewenza S. 2010. Pseudomonas aeruginosa produces an extracellular deoxyribonuclease that is required for utilization of DNA as a nutrient source. Environ. Microbiol. 12:1621-1629.
22. Ochsner UA, Wilderman PJ, Vasil AI, Vasil ML. 2002. GeneChip expression analysis of the iron starvation response in Pseudomonas aeruginosa: identification of novel pyoverdine biosynthesis genes. Mol. Microbiol. 45:1277-1287.
23. Overhage J, Bains M, Brazas MD, Hancock REW. 2008. Swarming of Pseudomonas aeruginosa is a complex adaptation leading to increased production of virulence factors and antibiotic resistance. J. Bacteriol. 190:2671-2679.
24. Potvin E, et al. 2003. In vivo functional genomics of Pseudomonas aeruginosa for high-throughput screening of new virulence factors and antibacterial targets. Environ. Microbiol. 5:1294-1308.
25. Rahme LG, et al. 1995. Common virulence factors for bacterial pathogenicity in plants and animals. Science 268:1899-1902.
26. Rowe SM, Miller S, Sorscher EJ. 2005. Cystic fibrosis. N. Engl. J. Med. 352:1992-2001.
27. Rüberg S, Pühler A, Becker A. 1999. Biosynthesis of the exopolysaccharide galactoglucan in Sinorhizobium meliloti is subject to a complex control by the phosphate-dependent regulator PhoB and the proteins ExpG and MucR. Microbiology 145:603-611.
28. Slater H, Crow M, Everson L, Salmond GP. 2003. Phosphate availability regulates biosynthesis of two antibiotics, prodigiosin and carbapenem, in Serratia via both quorum-sensing-dependent and -independent pathways. Mol. Microbiol. 47:303-320.
29. Stover CK, et al. 2000. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature 406:959-964.
30. von Krüger WM, et al. 2006. The phosphate-starvation response in Vibrio cholerae O1 and phoB mutant under proteomic analysis: disclosing functions involved in adaptation, survival and virulence. Proteomics 6:1495-1511.
31. Winans SC. 1990. Transcriptional induction of an Agrobacterium regulatory gene at tandem promoters by plant-released phenolic compounds, phosphate starvation, and acidic growth media. J. Bacteriol. 172:2433-2438.
32. Wu H, et al. 2000. Identification and characterization of two chemotactic transducers for inorganic phosphate in Pseudomonas aeruginosa. J. Bacteriol. 182:3400-3404.
33. Zaborin A, et al. 2009. Red death in Caenorhabditis elegans caused by Pseudomonas aeruginosa PAO1. Proc. Natl. Acad. Sci. U. S. A. 106:6327-6332.
34. Zavaleta-Pastor M, et al. 2010. Sinorhizobium meliloti phospholipase C required for lipid remodeling during phosphorus limitation. Proc. Natl. Acad. Sci. U. S. A. 107:302-307.