Induction of DNA double-strand breaks by monochlorophenol isomers and ChKM in human gingival fibroblasts

Archives of Toxicology

Volumn 86, Issue 9, 2012, Pages 1423-1429

  Shehata, M ^a   Durner, J ^a   Thiessen, D ^a   Shirin, M ^a   Lottner, S ^a   Van Landuyt, K ^a   Furche, S ^a   Hickel, R ^a   Reichl, F X ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

H2AX; DNA DSBs; Human gingival fibroblasts; Monochlorophenols; Walkhoff solution

Indexed keywords

2 CHLOROPHENOL; 3 CHLOROPHENOL; 4 CHLOROPHENOL; CAMPHOR; CHLOROPHENOL; DIMETHYL SULFOXIDE; DISINFECTANT AGENT; HISTONE H2AX; HYDROGEN PEROXIDE; TETRAZOLIUM; UNCLASSIFIED DRUG; WALKHOFF SOLUTION;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY TEST; DNA DETERMINATION; DOUBLE STRANDED DNA BREAK; FIBROBLAST CULTURE; GENE INDUCTION; GENOTOXICITY; HISTONE PHOSPHORYLATION; HUMAN; HUMAN CELL; ISOMER; PRIORITY JOURNAL;

CAMPHOR; CELL SURVIVAL; CELLS, CULTURED; CHLOROPHENOLS; DENTAL DISINFECTANTS; DNA BREAKS, DOUBLE-STRANDED; DRUG COMBINATIONS; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GINGIVA; HISTONES; HUMANS; INHIBITORY CONCENTRATION 50; ISOMERISM; MENTHOL; MUTAGENICITY TESTS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL;

DRYOBALANOPS;

EID: 84866125272     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0861-z     Document Type: Article

References (23)

1. Alt A, Lammens K, Chiocchini C, Lammens A, Pieck JC, Kuch D, Hopfner KP, Carell T (2007) Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta. Science 318(5852):967-970. doi:10.1126/science.1148242 (Pubitemid 350098991)
2. Berenbaum MC (1985) The expected effect of a combination of agents: the general solution. J Theor Biol 114(3):413-431 (Pubitemid 16237898)
3. Borzelleca JF, Hayes JR, Condie LW, Egle JL Jr (1985) Acute toxicity of monochlorophenols, dichlorophenols and pentachlorophenol in the mouse. Toxicol Lett 29(1):39-42 (Pubitemid 16210246)
4. Cooper GS, Jones S (2008) Pentachlorophenol and cancer risk: focusing the lens on specific chlorophenols and contaminants. Environ Health Perspect 116(8):1001-1008. doi:10.1289/ehp.11081
5. Da Silva GN, De Camargo EA, Salvadori DM, Ribeiro DA (2007) Genetic damage in human peripheral lymphocytes exposed to antimicrobial endodontic agents. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104(2):e58-e61. doi:10.1016/j.tripleo. 2007.02.009
6. Dimitriu B, Varlan C, Suciu I, Varlan V, Bodnar D (2009) Current considerations concerning endodontically treated teeth: alteration of hard dental tissues and biomechanical properties following endodontic therapy. J Med Life 2(1):60-65
7. Farrell A, Quilty B (1999) Degradation of mono-chlorophenols by a mixed microbial community via a meta- cleavage pathway. Biodegradation 10(5):353-362
8. Forst HT (1985) Problems of multiple tests and evaluations in drug research. Arzneimittelforschung 35(3):563-569
9. Gulcan HO, Liu Y, Duffel MW (2008) Pentachlorophenol and other chlorinated phenols are substrates for human hydroxysteroid sulfotransferase hSULT2A1. Chem Res Toxicol 21(8):1503-1508. doi:10.1021/tx800133d
10. Harrison JW, Madonia JV (1971) The toxicity of parachlorophenol. Oral Surg Oral Med Oral Pathol 32(1):90-99
11. Kasugai S, Hasegawa N, Ogura H (1991) Application of the MTT colorimetric assay to measure cytotoxic effects of phenolic compounds on established rat dental pulp cells. J Dent Res 70(2):127-130
12. Llamas R, Segura JJ, Jimenez-Rubio A, Jimenez-Planas A (1997) In vitro effect of parachlorophenol and camphorated parachlorophenol on macrophages. J Endod 23(12):728-730. doi:10.1016/ S0099-2399(97)80343-3 (Pubitemid 127730569)
13. Lobrich M, Rief N, Kuhne M, Heckmann M, Fleckenstein J, Rube C, Uder M (2005) In vivo formation and repair of DNA doublestrand breaks after computed tomography examinations. Proc Natl Acad Sci USA 102(25):8984-8989. doi:10.1073/pnas.0501 895102 (Pubitemid 40881065)
14. Nair PN (2004) Pathogenesis of apical periodontitis and the causes of endodontic failures. Crit Rev Oral Biol Med 15(6):348-381 (Pubitemid 44574225)
15. Nirmalakhandan N, Arulgnanendran V, Mohsin M, Sun B, Cadena F (1994) Toxicity of mixtures of organic chemicals to microorganisms. Water Res 28(3):543-551. doi:10.1016/0043-1354(94) 90005-1
16. Schorr S, Schneider S, Lammens K, Hopfner KP, Carell T (2010) Mechanism of replication blocking and bypass of Y-family polymerase {eta} by bulky acetylaminofluorene DNA adducts.Proc Natl Acad Sci USA 107(48):20720-20725. doi:10.1073/ pnas.1008894107
17. Sedelnikova OA, Rogakou EP, Panyutin IG, Bonner WM (2002) Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiat Res 158(4):486-492
18. Soekanto A, Kasugai S, Mataki S, Ohya K, Ogura H (1996) Toxicity of camphorated phenol and camphorated parachlorophenol in dental pulp cell culture. J Endod 22(6):284-289. doi:10.1016/ S0099-2399(96)80259-7
19. Solyanikova IP, Golovleva LA (2004) Bacterial degradation of chlorophenols: pathways, biochemica, and genetic aspects. J Environ Sci Health B 39(3):333-351 (Pubitemid 38669646)
20. Urcan E, Scherthan H, Styllou M, Haertel U, Hickel R, Reichl FX (2010) Induction of DNA double-strand breaks in primary gingival fibroblasts by exposure to dental resin composites. Biomaterials 31(8):2010-2014. doi:10.1016/j.biomaterials.2009. 11.065
21. Violich DR, Chandler NP (2010) The smear layer in endodontics- a review. Int Endod J 43(1):2-15. doi:10.1111/j.1365-2591.2009. 01627.x
22. Waltimo T, Trope M, Haapasalo M, Orstavik D (2005) Clinical efficacy of treatment procedures in endodontic infection control and one year follow-up of periapical healing. J Endod 31(12): 863-866 (Pubitemid 41698502)
23. Zhao F, Mayura K, Hutchinson RW, Lewis RP, Burghardt RC, Phillips TD (1995) Developmental toxicity and structure-activity relationships of chlorophenols using human embryonic palatal mesenchymal cells. Toxicol Lett 78(1):35-42