A tale of two glucose transporters: How GLUT2 re-emerged as a contender for glucose transport into the human beta cell

Diabetologia

Volumn 55, Issue 9, 2012, Pages 2312-2315

  Van De Bunt, M ^a   Gloyn, A L ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Beta cells; Glucose transporter; Human islets; Neonatal diabetes

Indexed keywords

GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 2; GLUCOSE TRANSPORTER 3; INSULIN;

GENE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GLUCOSE TRANSPORT; GLUCOSURIA; HUMAN; INSULIN RELEASE; NEWBORN DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SLC2A2 GENE; VERY LOW BIRTH WEIGHT;

DIABETES MELLITUS; FANCONI SYNDROME; FEMALE; GLUCOSE TRANSPORTER TYPE 2; HUMANS; INSULIN; MALE; MUTATION;

EID: 84866123477     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2612-3     Document Type: Review

References (17)

1. Thanabalasingham G, Owen KR (2011) Diagnosis and management of maturity onset diabetes of the young (MODY). BMJ 343:d6044
2. Waterfield T, Gloyn AL (2008) Monogenic β-cell dysfunction in children: clinical phenotypes, genetic etiology and mutational pathways. Ped Health 2:517-532
3. Pearson ER, Flechtner I, Njolstad PR et al (2006) Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. N Engl J Med 355:467-477
4. Rafiq M, Flanagan SE, Patch AM, Shields BM, Ellard S, Hattersley AT (2008) Effective treatment with oral sulfonylureas in patients with diabetes due to sulfonylurea receptor 1 (SUR1) mutations. Diabetes Care 31:204-209
5. Yamagata K, Oda N, Kaisaki PJ et al (1996) Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3). Nature 384:455-458
6. De Vos A, Heimberg H, Quartier E et al (1995) Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression. J Clin Invest 96:2489-2495
7. Bosco D, Armanet M, Morel P et al (2010) Unique arrangement of alpha- and beta-cells in human islets of Langerhans. Diabetes 59:1202-1210
8. 1 in enhancing human β-cell replication and function in vivo. Diabetes 58:882-893
9. Braun M, Ramracheya R, Bengtsson M et al (2008) Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion. Diabetes 57:1618-1628
10. Guillam MT, Hummler E, Schaerer E et al (1997) Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Nat Genet 17:327-330
11. Chen C, Thorens B, Bonner-Weir S, Weir GC, Leahy JL (1992) Recovery of glucose-induced insulin secretion in a rat model of NIDDM is not accompanied by return of the B-cell GLUT2 glucose transporter. Diabetes 41:1320-1327
12. McCulloch LJ, van de Bunt M, Braun M, Frayn KN, Clark A, Gloyn AL (2011) GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus. Mol Genet Metab 104:648-653
13. + channels in human pancreatic beta cells early in development. Diabetologia 50:1000-1005
14. Sansbury FH, Flanagan SE, Houghton JAL, et al SLC2A2 mutations can cause neonatal diabetes, suggesting GLUT2 may have a role in human insulin secretion. Diabetologia. doi: 10.1007/s00125-012-2595-0
15. Santer R, Steinmann B, Schaub J (2002) Fanconi-Bickel syndromea congenital defect of facilitative glucose transport. Curr Mol Med 2:213-227
16. Ingelsson E, Langenberg C, Hivert MF et al (2010) Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes 59:1266-1275
17. Mally MI, Otonkoski T, Lopez AD, Hayek A (1994) Developmental gene expression in the human fetal pancreas. Pediatr Res 36:537-544