Correlation between bone mineral densitometry and liver/heart iron overload evaluated by quantitative T2* MRI

Hematology

Volumn 17, Issue 5, 2012, Pages 297-301

  Ebrahimpour, Laleh ^a   Akhlaghpoor, Shahram ^a,b   Azarkayvan, Azita ^c   Salehi, Maryam ^a   Morteza, Afsaneh ^d   Alinaghi, Reza ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Noor Medical Imaging Center   (Iran)

^c HIGH INSTITUTE FOR RESEARCH AND EDUCATION IN TRANSFUSION MEDICINE   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Beta thalassemia; Bone mineral density; Ferritin; Iron deposition; Magnetic resonance imaging; T2*; Value

Indexed keywords

FERRITIN;

ADULT; AGE; ARTICLE; BETA THALASSEMIA; BONE DENSITOMETRY; BONE MINERAL; CLINICAL PROTOCOL; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; FEMUR; FERRITIN BLOOD LEVEL; HEART DISEASE; HUMAN; IRON OVERLOAD; LIVER DISEASE; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; MULTI ECHO FAST GRADIENT ECHO SEQUENCE; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOPENIA; OSTEOPOROSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; RADIOLOGICAL PROCEDURES; SCORING SYSTEM; SEX; THALASSEMIA INTERMEDIA; THALASSEMIA MAJOR;

ADOLESCENT; ADULT; BONE DENSITY; CROSS-SECTIONAL STUDIES; FEMALE; HEART; HUMANS; IRON OVERLOAD; LIVER; MAGNETIC RESONANCE IMAGING; MALE; MYOCARDIUM; OSTEOMALACIA; OSTEOPOROSIS; PROSPECTIVE STUDIES; THALASSEMIA;

EID: 84866120288     PISSN: 10245332     EISSN: 16078454     Source Type: Journal    
DOI: 10.1179/1607845412Y.0000000013     Document Type: Article

References (21)

1. Dines DM, Canale VC, Arnold WD. Fractures in thalassemia. J Bone Joint Surg Am. 1976;58:662-6.
2. Exarchou E, Politou C, Vretou E, Pasparakis D, Madessis G, Caramerou A. Fractures and epiphyseal deformities in beta-thalassemia. Clin Orthop Relat Res. 1984;189:229-33.
3. Finsterbush A, Farber I, Mogle P, Goldfarb A. Fracture patterns in thalassemia. Clin Orthop Relat Res 1985; 192:132-6.
4. Gratwick GM, Bullough PG, Bohne WH, Markenson AL, Peterson CM. Thalassemic osteoarthropathy. Ann Intern Med. 1978;88:494-501.
5. Erlandson ME, Brilliant R, Smith CH. Comparison of sixty-six patients with thalassemia major and thirteen patients with thalassemia intermedia: including evaluations of growth, development, maturation and prognosis. Ann N Y Acad Sci. 1964;119: 727-35.
6. Vogiatzi MG, Autio KA, Mait JE, Schneider R, Lesser M, Giardina PJ. Low bone mineral density in adolescents with beta-thalassemia. Ann N Y Acad Sci. 2005;1054:462-6.
7. Voskaridou E, Terpos E. Pathogenesis and management of osteoporosis in thalassemia. Pediatr Endocrinol Rev. 2008; 6(Suppl. 1):86-93.
8. Chatterjee R, Bajoria R. Osteopenia-osteoporosis syndrome in patients with thalassemia: understanding of type of bone disease and response to treatment. Hemoglobin. 2009; 33(Suppl. 1):S136-8.
9. Mahachoklertwattana P, Sirikulchayanonta V, Chuansumrit A, Karnsombat P, Choubtum L, Sriphrapradang A, et al. Bone histomorphometry in children and adolescents with beta-thalassemia disease: iron-associated focal osteomalacia. J Clin Endocrinol Metab. 2003;88:3966-72.
10. Anderson LJ, Holden S, Davis B, Prescott E, Charrier CC, Bunce NH, et al. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J. 2001;22:2171-9.
11. Kyriakou A, Savva SC, Savvides I, Pangalou E, Ioannou YS, Christou S, et al. Gender differences in the prevalence and severity of bone disease in thalassaemia. Pediatr Endocrinol Rev. 2008;6(Suppl. 1):116-22.
12. Leung TF, Hung EC, Lam CW, Li CK, Chu Y, Chik KW, et al. Bone mineral density in children with thalassaemia major: determining factors and effects of bone marrow transplantation. Bone Marrow Transplant. 2005;36:331-6.
13. Terpos E, Voskaridou E. Treatment options for thalassemia patients with osteoporosis. Ann N Y Acad Sci. 2010;1202: 237-43.
14. Akhlaghpoor S, Ghahari A, Morteza A, Khalilzadeh O, Shakourirad A, Alinaghizadeh MR. Quantitative T2&z.ast; magnetic resonance imaging for evaluation of iron deposition in the brain of β-thalassemia patients. Clin Neuroradiol. 2011 [E-pub ahead of print, PMID 22159731].
15. Pietrapertosa AC, Minenna G, Colella SM, Santeramo TM, Renni R, D'Amore M. Osteoprotegerin and RANKL in the pathogenesis of osteoporosis in patients with thalassaemia major. Panminerva Med. 2009;51:17-23.
16. Weinberg ED. Role of iron in osteoporosis. Pediatr Endocrinol Rev. 2008;6(Suppl. 1):81-5.
17. Chatterjee R, Katz M, Bajoria R. Use of hormone replacement therapy for correction of high turnover bone disease in hypogonadal beta-thalassemia major patients presenting with osteoporosis: comparison with idiopathic premature ovarian failure. Hemoglobin. 2011;35:653-8.
18. Musallam KM, Cappellini MD, Wood JC, Motta I, Graziadei G, Tamim H, et al. Elevated liver iron concentration is a marker of increased morbidity in patients with beta thalassemia intermedia. Haematologica. 2011;96: 1605-12.
19. Molyvda-Athanasopoulou E, Sioundas A, Karatzas N, Aggellaki M, Pazaitou K, Vainas I. Bone mineral density of patients with thalassemia major: four-year follow-up. Calcif Tissue Int. 1999;64:481-4.
20. Voskaridou E, Kyrtsonis MC, Terpos E, Skordili M, Theodoropoulos I, Bergele A, et al. Bone resorption is increased in young adults with thalassaemia major. Br J Haematol. 2001; 112:36-41.
21. Jensen CE, Tuck SM, Agnew JE, Koneru S, Morris RW, Yardumian A, et al. High prevalence of low bone mass in thalassaemia major. Br J Haematol. 1998;103:911-5.