Development and neurodegeneration: Turning HD pathogenesis on its head

Neurology

Volumn 79, Issue 7, 2012, Pages 621-622

  Marder, Karen ^a   Mehler, Mark F ^b  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUNTINGTIN;

ALZHEIMER DISEASE; BRAIN SIZE; EDITORIAL; GAIN OF FUNCTION MUTATION; GASTRULATION; GENE FUNCTION; GERM LAYER; HUMAN; HUNTINGTON CHOREA; LOSS OF FUNCTION MUTATION; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NEURAL STEM CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

EID: 84866111172     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3182648bfe     Document Type: Editorial

References (10)

1. Molero AE, Gokhan S, Gonzalez S, Feig JL, Alexandre LC, Mehler MF. Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington's disease. Proc Natl Acad Sci USA 2009;106:21900 -21905.
2. Zuccato C, Valenza M, Cattaneo E. Molecular mechanisms and potential therapeutical targets in Huntington's disease. Physiol Rev 2010;90:905-981.
3. Godin JD, Colombo K, Molina-Calavita M, et al. Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis. Neuron 2010;67:392- 406.
4. Keryer G, Pineda JR, Liot G, et al. Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease. J Clin Invest 2011;121:4372- 4382.
5. Lee JK, Mathews K, Schlaggar B, et al. Measures of growth in children at risk for Huntington disease. Neurology 2012;79:668-674.
6. Nopoulos PC, Aylward EH, Ross CA, et al. Smaller intracranial volume in prodromal Huntington's disease: evidence for abnormal neurodevelopment. Brain 2011;134: 137-142.
7. Aylward EH, Liu D, Nopoulos PC, et al. Striatal volume contributes to the prediction of onset of Huntington disease in incident cases. Biol Psychiatry 2012;71:822- 828.
8. Perneczky R, Wagenpfeil S, Lunetta KL, et al. Head circumference, atrophy, and cognition: implications for brain reserve in Alzheimer disease. Neurology 2010;75:137-142.
9. Marder K, Zhao H, Eberly S, et al. Dietary intake in adults at risk for Huntington disease: analysis of PHAROS research participants. Neurology 2009;73:385-392.
10. Woda JM, Calzonetti T, Hilditch-Maguire P, Duyao MP, Conlon RA, MacDonald ME. Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo. BMC Dev Biol 2005;5:17.