Chemical sphicterotomy versus surgical sphicterotomy in the management of chronic fissure in ANO: A prospective, randomized trial

Journal of Clinical and Diagnostic Research

Volumn 6, Issue 6, 2012, Pages 1018-1021

  Suvarna, Rithin ^a   Panchami, ^b   Guruprasad Rai, D ^a  

^a AJIMS   (India)

^b FMMS   (India)

Author keywords

Fissure in ano; Sphincterotomy; Topical diltiazem

Indexed keywords

DILTIAZEM;

ADULT; AGED; ANALGESIA; ANUS FISSURE; ARTICLE; CHRONIC DISEASE; CLINICAL EFFECTIVENESS; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FECES INCONTINENCE; FEMALE; FLATULENCE; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT SAFETY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SPHINCTEROTOMY; TREATMENT DURATION; TREATMENT OUTCOME;

EID: 84866094985     PISSN: 2249782X     EISSN: 0973709X     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. APK. The pharmacological treatment of anal fissures-A future role in the primary care. Singapore Med J 2003; 44(3): 136-37.
2. Uwe W. Pharmacological sphincterotomy for chronic anal fissures with the use of the botulinum toxin A. J Cutan Aesthet Surg. 2008 Jul-Dec; 1(2): 58-63.
3. Jensen SL. Diet and other risk factors for fissure-in-ano. A prospective case control study. Dis Colon Rectum. 1988 Oct; 31(10):770-73.
4. Utzig MJ, Kroesen AJ, Buhr HJ. Concepts in the pathogenesis and the treatment of chronic anal fissures-a review of the literature. The American Journal of Gastroenterology 2003; 98: 968-74.
5. Hisham MA. A comparative study on oral and topical nifedipine in the treatment of chronic anal fissures. Sudanese Journal of Public Health 2012 (Oct); 5(4).
6. Jonas M, Scholefield JH. Anal fissures. Gastroenterol Clin North Am 2001; 30(1):167-81.
7. Gupta P J. The treatment of fissure in ano-revisited. Afr Health Sci. 2004 April; 4(1): 58-62.
8. Golfam F, Golfam P, Khalaj A, Mortaz S S S. The effect of topical nifedipine in the treatment of chronic anal fissures. Acta Medica Iranica 2010; 48(5): 295-99.
9. Jonathan NL, John HS. A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in the treatment of anal fissures. The Lancet 1997; 349:11-14.
10. Garcea G, Sutton C, Mansoori S, Lloyd T, Thomas M. The results following conservative lateral sphincteromy for the treatment of chronic anal fissures. Colorectal Disease 2003(July); 5(4): 311-14.
11. Dhawan S, Chopra S. Nonsurgical approaches for the treatment of anal fissures. The American Journal of Gastroenterology 2007; 102: 1312-21.
12. Cook TA, Brading AF, Mortensen NJ. The contractile properties of the ano-rectal smooth muscle. Br J Surg 1999; 86:70-75.
13. Haq Z, Rahman M, Chowdhury RA, Baten MA, Khatun M. Chemical sphincterotomy-the first line of treatment for chronic anal fissures. Mymensingh Med J. 2005 Jan; 14(1):88-90.
14. Carapeti EA, Kamm MA, Mc Donald PJ. A randomised controlled trial that showed that glyceryl trinitrate heals anal fissures, that higher doses are not more effective, and that there is a high recurrence rate. GUT 1999; 44:727-30.
15. Zuberi BF, Rajput MR, Abro H, Shaikh SA. A randomised trial of the glyceryl trinitrate ointment and the nitroglycerin patch in the healing of anal fissures. Int J Colorectal Dis 2000; 15:243-45.
16. Carapeti EA, Kamm MA, Evans BK, Phillips RKS. Topical diltiazem and bethanechol decrease the anal sphincter pressure without side effects. Gut 1999; 45:719-22.
17. Lund JN, Scholefield JH. A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in the treatment of anal fissures. Lancet 1997; 349:11-14.
18. Kennedy ML, Sowter S, Nguyen H, Lubowski DZ. Glyceryl trinitrate ointment for the treatment of chronic anal fissures: the results of a placebo-controlled trial and a long term follow-up. Dis Colon Rectum 1999; 42(8):1000-06.
19. Knight JS, Birks M, Farouk R. The topical diltiazem ointment in the treatment of chronic anal fissures. Br J Surg. 2001; 88(4):553-56.
20. Carapeti EA, Kamm MA, Phillips RKS. Topical diltiazem and bethanecol decrease the anal sphincter pressure and heal anal fissures without side effects. Dis Colon Rectum 2000; 43:1359-62.
21. Antropoli C, Perrotti P, Rubino M, Martino A, De Stefano G, Migliore G, et al. Nifedipine for local use in the conservative treatment of anal fissures: the preliminary results of a multicentre study. Dis Colon Rectum 1999; 42(8):1011-15.
22. Perrotti P, Bove A, Antropoli C, Molino D, Antropoli M, Balzano A, et al. Topical nifedipine with lidocaine ointment vs. active control for the treatment of chronic anal fissures: the results of a prospective, randomized, double-blind study. Dis Colon Rectum 2002; 45(11): 1468-75.
23. Kocher HM, Steward M, Leather AJ, Cullen PT. A randomised clinical trial which assessed the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissures. Br J Surg 2002; 89:413-17.