Potential hepato-protective effect of α-tocopherol or simvastatin in aged rats

Pharmacological Reports

Volumn 64, Issue 3, 2012, Pages 698-705

  Helmy, Mai M ^a  

^a Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

Aging liver; Antioxidant enzymes; Reactive oxygen species; Simvastatin; tocopherol

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALPHA TOCOPHEROL; ASPARTATE AMINOTRANSFERASE; CATALASE; CHOLESTEROL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LOW DENSITY LIPOPROTEIN; NITRATE; NITRITE; SIMVASTATIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL;

AGED; AGING; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; LIPID ANALYSIS; LIPOPROTEIN BLOOD LEVEL; LIVER FUNCTION; LIVER INJURY; LIVER PROTECTION; MALE; NONHUMAN; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84866081968     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(12)70864-2     Document Type: Article

References (42)

1. Aebi H: Catalase in vitro. Methods Enzymol, 1984, 105, 121-126.
2. Arivazhagan P, Ramanathan K, Panneerselvam C: Effect of dl-α-lipoic acid on glutathione metabolic enzymes in aged rats. Exp Gerontol, 2001, 37, 81-87.
3. Bonnetti PO, Lerman LO, Napoli C, Lerman A: Statin effects beyond lipid-lowering - are they clinically relevant? Eur Heart J, 2003, 24, 225-248.
4. + metabolism oxidative stress and Sirt1 activity in wistar rats. PLoS One, 2011, 6, e19194.
5. Burton GW: Vitamin E: molecular and biological function. Proc Nutr Soc, 1994, 53, 251-262.
6. Burton GW, Wronska U, Stone L, Foster DO, Ingold KU, Biokinetics of dietary RRR-α-tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E. Evidence that vitamin C does not "spare" vitamin E in vivo. Lipids, 1990, 25, 199-210.
7. Cand F, Verdetti J: Superoxide dismutase, glutathione peroxidase, catalase, and lipid peroxidation in the major organs of the aging rats. Free Radic Biol Med, 1989, 7, 59-63.
8. Castro MD, Suarez E, Kraiselburd E, Isidro A, Paz J, Ferder L, Ayala-Torres S: Aging increases mitochondrial DNA damage and oxidative stress in liver of rhesus monkeys. Exp Gerontol, 2012, 47, 29-37.
9. Ceballos-Picot I, Nicole A, Clément M, Bourre JM, Sinet PM: Age-related changes in antioxidant enzymes and lipid peroxidation in brains of control and transgenic mice overexpressing copper-zinc superoxide dismutase. Mutat Res, 1992, 275, 281-293.
10. Dalla Y, Singh N, Jaggi AS, Singh D: Memory restorative role of statins in experimental dementia: an evidence of their cholesterol dependent and independent actions. Pharmacol Rep, 2010, 62, 784-796.
11. De Young L, Yu D, Bateman RM, Brock GB: Oxidative stress and antioxidant therapy: Their impact in diabetes-associated erectile dysfunction. J Androl, 2004, 25, 830-836.
12. Dichtl W, Dulak J, Frick M, Alber HF, Schwarzacher SP, Ares MP, Nilsson J et al.: HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells. Arterioscler Thromb Vasc Biol, 2003, 23, 58-63.
13. Escames G, López LC, Ortiz F, Ros E, Acuña-Castroviejo D: Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment. Exp Gerontol, 2006, 41, 1165-1173.
14. Farooqui MY, Day WW, Zamorano DM: Glutathione and lipid peroxidation in the aging rat. Comp Biochem Physiol B, 1987, 88, 177-180.
15. Gündüz F, Sentürk UK, Kuru O, Aktekin B, Aktekin MR: The effect of one year's swimming exercise on oxidant stress and antioxidant capacity in aged rats. Physiol Res, 2004, 53, 171-176.
16. Habig WH, Pabst MJ, Jakoby WB: Glutathione S-transferases the first enzymatic step in mercapturic acid formation. J Biol Chem, 1974, 249, 7130-7139.
17. Hamden K, Carreau S, Ayadi F, Masmoudi H, El-Feki A: Inhibitory effect of estrogens, phytoestrogens and caloric restriction on oxidative stress and hepato-toxicity in aged rats. Biomed Environ Sci, 2009, 22, 381-387.
18. Harman D: Free radical theory of aging. Mutat Res, 2002, 275, 257-266.
19. Inman S, Davis N, Olson K, Lukaszek V: Simvastatin attenuates renal ischemia/reperfusion injury in rats administered cyclosporine A. Am J Med Sci, 2003, 326, 117-121.
20. Jung K, Henke W: Developmental changes of antioxidant enzymes in kidney and liver from rats. Free Radic Biol Med, 1996, 20, 613-617.
21. Kumar P, Kale RK, Baquer NZ: Estradiol modulates membrane-linked ATPases, antioxidant enzymes, membrane fluidity, lipid peroxidation, and lipofuscin in aged rat liver. J Aging Res, 2011, 580245.
22. Mahesh R, Bhuvana S, Begum VM: Effect of Terminalia chebula aqueous extract on oxidative stress and antioxidant status in the liver and kidney of young and aged rats. Cell Biochem Funct, 2009, 27, 358-363.
23. Marklund S, Marklund G: Involvement of superoxide anion radical in autoxidation of pyrogallol and a convenient assay for SOD. Eur J Biochem, 1974, 47, 469-474.
24. Mauriz JL, Matilla B, Culebras JM, González P, González-Gallego J: Dietary glycine inhibits activation of nuclear factor kappa B and prevents liver injury in hemorrhagic shock in the rat. Free Radic Biol Med, 2001, 31, 1236-1244.
25. Mauriz JL, Molpeceres V, García-Mediavilla MV, González P, Barrio JP, González-Gallego J: Melatonin prevents oxidative stress and changes in antioxidant enzyme expression and activity in the liver of aging rats. J Pineal Res, 2007, 42, 222-230.
26. Mayo JC, Tan DX, Sainz RM, Lopez-Burillo S, Reiter RJ: Oxidative damage to catalase induced by peroxyl radicals: functional protection by melatonin and other antioxidants. Free Radic Res, 2003, 37, 543-553.
27. Michiels C, Raes M, Toussaint O, Remacle J: Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress. Free Radic Biol Med, 1994, 17, 235-248.
28. Miyoshi N, Oubrahim H, Chock PB, Stadtman ER: Age dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Proc Natl Acad Sci USA, 2006, 103, 1727-1731.
29. Navarro-Arevalo A, Sanchez-del-Pino MJ: Age and exercise-related changes in lipid peroxidation and superoxide dismutase activity in liver and soleus muscle tissues of rats. Mech Ageing Dev, 1998, 104, 91-102.
30. Navarro-Gonzalvez JA, Garcia-Benayas C, Arenas J: Semi-automated measurement of nitrate in biological fluids. J Clin Chem, 1998, 44, 679-681.
31. Pagila DE, Valentine WN: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med, 1967, 70, 158-169.
32. Palomero J, Galán AI, Muñoz ME, Tuñón MJ, González-Gallego J, Jiménez R: Effects of aging on the susceptibility to the toxic effects of cyclosporin A in rats. Changes in liver glutathione and antioxidant enzymes. Free Radic Biol Med, 2001, 30, 836-845.
33. Parildar-Karpuzoǧlu H, Mehmetçik G, Özdemirler-Erata1 G, Doǧru-Abbasoǧlu S, Koçak-Toker N, Uysal M: Effect of taurine treatment on pro-oxidant antioxidant balance in livers and brains of old rats. Pharmacol Rep, 2008, 60, 673-678.
34. Pigeolet E, Corbisier P, Houbion A, Lambert D, Michiels C, Raes M, Zachary MD, Remacle J: Glutathione peroxidase, superoxide dismutase, and catalase inactivation by peroxides and oxygen derived free radicals. Mech Ageing Dev, 1990, 51, 283-297.
35. Poderoso JJ, Carreras MC, Lisdero C, Riobó NA, Schöpfer F, Boveris A: Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles. Arch Biochem Biophys, 1996, 328, 85-92.
36. Richardson RJ, Murphy SD: Effect of glutathione depletion on tissue deposition of methylmercury in rats. Toxicol Appl Pharmacol, 1975, 31, 505-519.
37. Rikans LE, Hornbrook KR: Lipid peroxidation, antioxidant protection and aging. Biochim Biophys Acta, 1997, 1362, 116-127.
38. Rodríguez MI, Escames G, López LC, López A, García JA, Ortiz F, Sánchez V et al.: Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice. Exp Gerontol, 2008, 43, 749-756.
39. Szabó C: Multiple pathways of peroxinitrite cytotoxicity. Toxicol Lett, 2003, 140-141, 105-112.
40. Uchiyama M, Mihara M: Determination of malondialdehyde precursor in tissues by thiobarbituric acid test. Anal Biochem, 1978, 86, 271-278.
41. van Haaften RI, Haenen GR, Evelo CT, Bast A: Effect of vitamin E on glutathione-dependent enzymes. Drug Metab Rev, 2003, 35, 215-253.
42. Warner HR: Superoxide dismutase, aging, and degenerative disease. Free Radic Biol Med, 1994, 17, 249-258.