Atovaquone ameliorate gastrointestinal Toxoplasmosis complications in a pregnancy model

Medical Science Monitor

Volumn 18, Issue 9, 2012, Pages

  Oz, Helieh S ^a   Tobin, Thomas ^b  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Atovaquone; Feto maternal Toxoplasmosis; Gastrointestinal; Hepatitis; Pregnancy

Indexed keywords

ATOVAQUONE;

ABORTION; ALLODYNIA; ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASCITES; CELL INVASION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; EPITHELIOID CELL; FEMALE; HEPATITIS; HISTOPATHOLOGIC SKIN REACTION; INFLAMMATORY CELL; LIVER CELL NUCLEUS; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MONONUCLEAR CELL; MOUSE; MULTINUCLEAR CELL; NECROSIS; NONHUMAN; PANCREATITIS; PLASMA CELL; PREGNANCY DISORDER; PREMATURITY; STILLBIRTH; TACHYZOITE; TOXOPLASMOSIS;

EID: 84866081373     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.883342     Document Type: Article

References (39)

1. Dubey JP, Jones JL: Toxoplasma gondii infection in humans and animals in the United States. Int J Parasitol, 2008; 38: 1257-78
2. Jones JL, Kruszon-Moran D, Wilson M et al: Toxoplasma gondii infection in the United States: Seroprevalence and risk factors. Amer J Epidemiol, 2001; 154: 357-65
3. Buxton D, Thomson K, Maley S et al: Vaccination of sheep with a live incomplete strain (S48) of Toxoplasma gondii and their immunity to challenge when pregnant. Vet Rec, 1991; 129: 89-93
4. Wolf A, Cowen D, Paige B: Human Toxoplasmosis: occurrence in infants as an encephalomyelitis verification by transmission to animals. Science, 1939; 89: 226-27
5. Jones JL, Lopez A, Wilson M et al: Congenital Toxoplasmosis: A review. Obst Gynecol Surv 2001,56: 296-305.
6. Wong SY, Remington JS: Toxoplasmosis in pregnancy. Clin Infect Dis, 1994; 18: 853-61
7. Brown AS, Schaefer CA, Quesenberry CP Jr et al: Maternal exposure to Toxoplasmosis and risk of schizophrenia in adult offspring. Am J Psychiatry, 2005; 162: 767-73
8. Bachmann S, Schröder J, Bottmer C et al: Psychopathology in first-episode schizophrenia and antibodies to Toxoplasma gondii. Psychopathology, 2005; 38: 87-90
9. Wang HL, Wang GH, Li QY et al: Prevalence of Toxoplasma infection in first-episode schizophrenia and comparison between Toxoplasmaseropositive and Toxoplasma-seronegative schizophrenia. Acta Psychiatr Scand, 2006; 114: 40-48
10. Cortina-Borja M, Tan HK, Wallon M et al.; European Multicentre Study on Congenital Toxoplasmosis (EMSCOT): Prenatal treatment for serious neurological squeal of congenital Toxoplasmosis: an observational prospective cohort study. PLoS Med, 2010; 12(7) pii: e1000351
11. Oz HS, Hughes W, Rehg J: A rat model for dual opportunistic pathogens: Cryptosporidium parvum and Pneumocystis carinii. Lab Animal Sci, 1999; 49: 331-34
12. Hudson AT, Dickins M, Ginger CD et al: 566C80: a potent broad spectrum anti-infective agent with activity against malaria and opportunistic infections in AIDS patients. Drugs Exp Clin Res, 1991; 17: 427-35
13. Hughes W, Oz HS: Successful prevention and treatment of babesiosis with atovaquone. J Infect Dis, 1995; 172: 1042-46
14. Oz HS, Westlund KH: "Human Babesiosis" an emerging transfusion dilemma. Int J Hepatol, 2012; doi:10.1155/2012/431761
15. Daffos F, Forestier F, Capella-Pavlovsky M et al: Prenatal management of 746 pregnancies at risk for congenital Toxoplasmosis. N Engl J Med, 1998; 318: 271-75
16. Berrebi A, Assouline C, Bessieres MH et al: Long-term outcome of children with congenital Toxoplasmosis. Am J Obstet Gynecol, 2010; 203: 552. e1-6
17. Habib FA: Post-treatment assessment of acute Toxoplasma infection during pregnancy. J Obstet Gynaecol, 2008; 28: 593-95
18. Julliac B, Theophile H, Begorre M, Richez B, Haramburu F: Side effects of spiramycin masquerading as local anesthetic toxicity during labor epidural analgesia. Int J Obstet Anesth, 2010; 19: 331-32
19. Dubey JP, Ferreira LR, Martins J, McLeod R: Oral oocyst-induced mouse model of Toxoplasmosis: effect of infection with Toxoplasma gondii strains of different genotypes, dose, and mouse strains (transgenic, out-bred, in-bred) on pathogenesis and mortality. Parasitology, 2011; 14: 1-13
20. Takahashi J, Fukuda T, Tanaka J et al: Bax-induced apoptosis not demonstrated in the congenital Toxoplasmosis in mice. Brain Dev, 2001; 23: 50-53
21. Howe DK, Honore S, Derouin F, Sibley LD: Determination of genotypes of Toxoplasma gondii strains isolated from patients with Toxoplasmosis. J Clin Microbiol, 1997; 35: 1411-14
22. Su C, Howe DK, Dubey JP et al: Identification of quantitative trait loci controlling acute virulence in Toxoplasma gondii. PNAS, 2002; 99: 10753-58
23. Oz HS, Ebersole J, de Villiers W: The Macrophage Pattern Recognition Scavenger Receptors SR-A and CD36 protect against microbial induced pregnancy loss. Inflam Res, 2011: 60: 93-97
24. Oz HS, Chen T, Nagasawa H: Comparative Efficacies of Two Cysteine Prodrugs and a Glutathione Delivery Agent in a Colitis Model. Transl Res, 2007; 150: 122-29
25. Oz HS, Im H, Chen T et al: Glutathione enhancing agents protect against Steatohepatitis in a model. J Biochem Mol Toxicol, 2006; 20: 39-47
26. Westlund KH, Zhang L, Ma F, Oz HS: Chronic inflammation and pain in a tumor necrosis factor receptor (TNFR) (p55/p75-/-) dual deficient murine model. Transl Res, 2012; 160(1): 84-94
27. Mead PS, Slutsker L, Dietz V et al: Food-related illness and death in the United States. Emerg Infect Dis, 1999; 5: 606-25
28. Prandota J: The importance of toxoplasma gondii infection in diseases presenting with headaches. Headaches and aseptic meningitis may be manifestations of the Jarisch-Herxheimer reaction. Int J Neurosci, 2009; 119: 2144-82
29. Machado FS, Johndrow JE, Esper L et al: Anti-inflammatory actions of lipoxin A4 and Aspirin-triggered lipoxin are SOCS-2 dependent. Nat Med, 2006; 12: 330-34
30. Ajzenberg D, Cogne N, Paris L et al: Genotype of 86 Toxoplasma gondii isolates associated with human congenital Toxoplasmosis, and correlation with clinical findings. J Infect Dis, 2002; 186: 684-89
31. Howe DK, Sibley LD: Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease. J Infect Dis, 1995; 172: 1561-66
32. Sibley LD, Howe DK: Genetic basis of pathogenicity in Toxoplasmosis. Curr Top Microbiol Immunol, 1996; 219: 3-16
33. Araujo FG, Slifer T: Different Strains of Toxoplasma gondii Induce Different Cytokine Responses in CBA/Ca Mice. Infect Immun, 2003; 71: 4171-414
34. Freyre A, Falcon J, Mendez J, Gonzalez M: Toxoplasma gondii: an improved rat model of congenital infection. Exp Parasitol, 2008; 120: 142-46
35. Srivastava IK, Vaidya AB: A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother, 1999; 43: 1334-39
36. Rolan PE, Mercer AJ, Tate E et al: Disposition of atovaquone in humans. Antimicrob Agents Chemother, 1997; 41: 1319-21
37. Dunay IR, Heimesaat MM, Bushrab FN et al: Atovaquone Maintenance Therapy Prevents Reactivation of Toxoplasmic Encephalitis in a Murine Model of Reactivated Toxoplasmosis. Antimicrob Agents Chempther, 2004; 48: 4848-54
38. Elsheikha HM, Khan NA: Protozoa traversal of the blood brain barrier to invade the central nervous system. FEMS Microbiol Rev, 2010; 34; 532-53
39. Kankova S, Sulc J, Flegr J: Increased pregnancy weight gain in women with latent Toxoplasmosis and RhD-positivity protection against this effect. Parasitology, 2010; 137: 1773-79