Breaking Tolerance in Transgenic Mice Expressing the Human TSH Receptor A-Subunit: Thyroiditis, Epitope Spreading and Adjuvant as a 'Double Edged Sword'

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  McLachlan, Sandra M ^a   Aliesky, Holly A ^a   Chen, Chun Rong ^a   Chong, Gao ^a   Rapoport, Basil ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FREUND ADJUVANT; THYROGLOBULIN; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR A SUBUNIT; THYROTROPIN RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; EPITOPE MAPPING; GENE EXPRESSION PROFILING; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; MOUSE; NONHUMAN; REGULATORY T LYMPHOCYTE; T CELL DEPLETION; THYROIDITIS; TRANSGENICS; WILD TYPE;

ADJUVANTS, IMMUNOLOGIC; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; EPITOPES; HUMANS; IMMUNE TOLERANCE; IMMUNOGLOBULIN G; IODIDE PEROXIDASE; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN SUBUNITS; RECEPTORS, THYROTROPIN; THYROIDITIS; THYROXINE;

ADENOVIRIDAE; BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; MUS; MUS MUSCULUS;

EID: 84866078688     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043517     Document Type: Article

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