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Volumn 55, Issue 10, 2012, Pages 2747-2758

Beneficial effects of the novel cholecystokinin agonist (pGlu-Gln)-CCK-8 in mouse models of obesity/diabetes

Author keywords

Cholecystokinin (CCK); Diabetes; Drug tolerance; Glucose tolerance; High fat; Insulin sensitivity; Obesity

Indexed keywords

CHOLECYSTOKININ; CHOLECYSTOKININ OCTAPEPTIDE; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; INSULIN; TRIACYLGLYCEROL;

EID: 84866074718     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2654-6     Document Type: Article
Times cited : (54)

References (37)
  • 1
    • 0000860646 scopus 로고
    • A hormone mechanism for gallbladder contraction and evacuation
    • Ivy AC, Oldberg E (1928) A hormone mechanism for gallbladder contraction and evacuation. Am J Physiol 65:599-613
    • (1928) Am J Physiol , vol.65 , pp. 599-613
    • Ivy, A.C.1    Oldberg, E.2
  • 3
    • 0024502461 scopus 로고
    • Cholecystokinin in pig plasma: Release of components devoid of a bioactive COOH-terminus
    • 2912150 1:CAS:528:DyaL1MXhtVylsbw%3D
    • Cantor P, Rehfeld JF (1989) Cholecystokinin in pig plasma: release of components devoid of a bioactive COOH-terminus. Am J Physiol 256:G53-G61
    • (1989) Am J Physiol , vol.256
    • Cantor, P.1    Rehfeld, J.F.2
  • 5
    • 33644841711 scopus 로고    scopus 로고
    • Cholecystokinin and gastrin receptors
    • DOI 10.1152/physrev.00014.2005
    • Dufresne M, Seva C, Fourmy D (2006) Cholecystokinin and gastrin receptors. Physiol Rev 86:805-847 (Pubitemid 44033383)
    • (2006) Physiological Reviews , vol.86 , Issue.3 , pp. 805-847
    • Dufresne, M.1    Seva, C.2    Fourmy, D.3
  • 6
    • 0002572979 scopus 로고
    • Cholecystokinin
    • J.H. Walsh G.J. Dockray (eds) Raven New York
    • Liddle RA (1994) Cholecystokinin. In: Walsh JH, Dockray GJ (eds) Gut peptides biochemistry and physiology. Raven, New York, pp 175-216
    • (1994) Gut Peptides Biochemistry and Physiology , pp. 175-216
    • Liddle, R.A.1
  • 7
    • 77954896463 scopus 로고    scopus 로고
    • Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival
    • 20534724 10.1210/en.2010-0233 1:CAS:528:DC%2BC3cXht1OjurfE
    • Lavine JA, Raess PW, Stapleton DS, Rabaglia ME, Suhonen JI, Schueler KL et al (2010) Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival. Endocrinology 151:3577-3588
    • (2010) Endocrinology , vol.151 , pp. 3577-3588
    • Lavine, J.A.1    Raess, P.W.2    Stapleton, D.S.3    Rabaglia, M.E.4    Suhonen, J.I.5    Schueler, K.L.6
  • 8
    • 65549144889 scopus 로고    scopus 로고
    • Recent advances in antidiabetic drug therapies targeting the enteroinsular axis
    • 19275548 10.2174/138920009787522124 1:CAS:528:DC%2BD1MXks1SqtLo%3D
    • Flatt PR, Bailey CJ, Green BD (2009) Recent advances in antidiabetic drug therapies targeting the enteroinsular axis. Curr Drug Metab 10:125-137
    • (2009) Curr Drug Metab , vol.10 , pp. 125-137
    • Flatt, P.R.1    Bailey, C.J.2    Green, B.D.3
  • 9
    • 57649234120 scopus 로고    scopus 로고
    • The incretin system and its role in type 2 diabetes mellitus
    • 18786605 10.1016/j.mce.2008.08.012 1:CAS:528:DC%2BD1cXhsFajt73P
    • Holst JJ, Vilsboll T, Deacon CF (2009) The incretin system and its role in type 2 diabetes mellitus. Mol Cell Endocrinol 297:127-136
    • (2009) Mol Cell Endocrinol , vol.297 , pp. 127-136
    • Holst, J.J.1    Vilsboll, T.2    Deacon, C.F.3
  • 10
    • 79952512270 scopus 로고    scopus 로고
    • Incretin physiology beyond glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: Cholecystokinin and gastrin peptides
    • 10.1111/j.1748-1716.2010.02235.x 1:CAS:528:DC%2BC3MXktVKitbs%3D
    • Rehfeld JF (2011) Incretin physiology beyond glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: cholecystokinin and gastrin peptides. Acta Physiol (Oxf) 201:405-411
    • (2011) Acta Physiol (Oxf) , vol.201 , pp. 405-411
    • Rehfeld, J.F.1
  • 11
    • 62749197307 scopus 로고    scopus 로고
    • Lack of tolerance development with long-term administration of PEGylated cholecystokinin
    • 19084041 10.1016/j.peptides.2008.11.010 1:CAS:528:DC%2BD1MXjvVWhuro%3D
    • Verbaeys I, León-Tamariz F, Buyse J, Decuypere E, Pottel H, Cokelaere M (2009) Lack of tolerance development with long-term administration of PEGylated cholecystokinin. Peptides 30:699-704
    • (2009) Peptides , vol.30 , pp. 699-704
    • Verbaeys, I.1    León-Tamariz, F.2    Buyse, J.3    Decuypere, E.4    Pottel, H.5    Cokelaere, M.6
  • 12
    • 52949134090 scopus 로고    scopus 로고
    • PEGylated cholecystokinin is more potent in inducing anorexia than conditioned taste aversion in rats
    • 18574458 10.1038/bjp.2008.257 1:CAS:528:DC%2BD1cXhtFKkurbJ
    • Verbaeys I, León-Tamariz F, Pottel H, Decuypere E, Swennen Q, Cokelaere M (2008) PEGylated cholecystokinin is more potent in inducing anorexia than conditioned taste aversion in rats. Br J Pharmacol 155:417-423
    • (2008) Br J Pharmacol , vol.155 , pp. 417-423
    • Verbaeys, I.1    León-Tamariz, F.2    Pottel, H.3    Decuypere, E.4    Swennen, Q.5    Cokelaere, M.6
  • 13
    • 33646724266 scopus 로고    scopus 로고
    • CCK1 antagonists: Are they ready for clinical use?
    • 16699265 10.1159/000090310
    • Peter SA, D'Amato M, Beglinger C (2006) CCK1 antagonists: are they ready for clinical use? Dig Dis 24:70-82
    • (2006) Dig Dis , vol.24 , pp. 70-82
    • Peter, S.A.1    D'Amato, M.2    Beglinger, C.3
  • 15
    • 0029978990 scopus 로고    scopus 로고
    • The in vivo metabolism of cholecystokinin (CCK-8) is essentially ensured by aminopeptidase A
    • DOI 10.1016/0196-9781(96)00036-8
    • Migaud M, Durieux C, Viereck J, Soroca-Lucas E, Fournié-Zaluski MC, Roques BP (1996) The in vivo metabolism of cholecystokinin (CCK-8) is essentially ensured by aminopeptidase A. Peptides 17:601-607 (Pubitemid 26238392)
    • (1996) Peptides , vol.17 , Issue.4 , pp. 601-607
    • Migaud, M.1    Durieux, C.2    Viereck, J.3    Soroca-Lucas, E.4    Fournie-Zaluski, M.-C.5    Roques, B.P.6
  • 16
    • 0031690197 scopus 로고    scopus 로고
    • Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymatic degradation
    • DOI 10.2337/diabetes.47.10.1619
    • O'Harte FP, Mooney MH, Kelly CM, Flatt PR (1998) Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymatic degradation. Diabetes 47:1619-1624 (Pubitemid 28445351)
    • (1998) Diabetes , vol.47 , Issue.10 , pp. 1619-1624
    • O'Harte, F.P.M.1    Mooney, M.H.2    Kelly, C.M.N.3    Flatt, P.R.4
  • 17
    • 69349096792 scopus 로고    scopus 로고
    • Fatty acid derivatised analogs of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties
    • 19523458 10.1016/j.bcp.2009.05.037 1:CAS:528:DC%2BD1MXhtFSnsrfE
    • Kerr BD, Irwin N, O'Harte FP, Bailey CJ, Flatt PR, Gault VA (2009) Fatty acid derivatised analogs of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. Biochem Pharmacol 78:1008-1016
    • (2009) Biochem Pharmacol , vol.78 , pp. 1008-1016
    • Kerr, B.D.1    Irwin, N.2    O'Harte, F.P.3    Bailey, C.J.4    Flatt, P.R.5    Gault, V.A.6
  • 19
    • 0019471997 scopus 로고
    • Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice
    • Flatt PR, Bailey CJ (1981) Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice. Diabetologia 20:573-577 (Pubitemid 11096955)
    • (1981) Diabetologia , vol.20 , Issue.5 , pp. 573-577
    • Flatt, P.R.1    Bailey, C.J.2
  • 20
    • 77955027548 scopus 로고    scopus 로고
    • 3)GIP improves metabolic status in high-fat-fed mice
    • 20649625 10.1111/j.1463-1326.2010.01228.x 1:CAS:528:DC%2BC3cXhtFGntbjF
    • 3)GIP improves metabolic status in high-fat-fed mice. Diabetes Obes Metab 12:744-751
    • (2010) Diabetes Obes Metab , vol.12 , pp. 744-751
    • Montgomery, I.A.1    Irwin, N.2    Flatt, P.R.3
  • 21
    • 0020086017 scopus 로고
    • Influence of genetic background and age on the expression of the obese hyperglycaemic syndrome in Aston ob/ob mice
    • Bailey CJ, Flatt PR, Atkins TW (1982) Influence of genetic background and age on the expression of the obese hyperglycemic syndrome in Aston ob/ob mice. Int J Obes 6:11-21 (Pubitemid 12157286)
    • (1982) International Journal of Obesity , vol.6 , Issue.1 , pp. 11-21
    • Bailey, C.J.1    Flatt, P.R.2    Atkins, T.W.3
  • 22
    • 80052101081 scopus 로고    scopus 로고
    • Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice
    • 21602512 10.2337/db10-0789 1:CAS:528:DC%2BC3MXptVChu7s%3D
    • Lo CM, Obici S, Dong HH, Haas M, Lou D, Kim DH et al (2011) Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice. Diabetes 60:2000-2007
    • (2011) Diabetes , vol.60 , pp. 2000-2007
    • Lo, C.M.1    Obici, S.2    Dong, H.H.3    Haas, M.4    Lou, D.5    Kim, D.H.6
  • 23
    • 79955518020 scopus 로고    scopus 로고
    • Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis
    • 21540554 10.1172/JCI43615 1:CAS:528:DC%2BC3MXlvFKntL0%3D
    • Ali S, Lamont BJ, Charron MJ, Drucker DJ (2011) Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis. J Clin Invest 121:1917-1929
    • (2011) J Clin Invest , vol.121 , pp. 1917-1929
    • Ali, S.1    Lamont, B.J.2    Charron, M.J.3    Drucker, D.J.4
  • 24
    • 78650067216 scopus 로고    scopus 로고
    • Regulation of pancreatic islet gene expression in mouse islets by pregnancy
    • 20847227 10.1677/JOE-10-0298 1:CAS:528:DC%2BC3cXhsFOmsr7O
    • Layden BT, Durai V, Newman MV, Marinelarena AM, Ahn CW, Feng G et al (2010) Regulation of pancreatic islet gene expression in mouse islets by pregnancy. J Endocrinol 207:265-279
    • (2010) J Endocrinol , vol.207 , pp. 265-279
    • Layden, B.T.1    Durai, V.2    Newman, M.V.3    Marinelarena, A.M.4    Ahn, C.W.5    Feng, G.6
  • 26
    • 33748744603 scopus 로고    scopus 로고
    • Is the CCK2 receptor essential for normal regulation of body weight and adiposity?
    • DOI 10.1111/j.1460-9568.2006.05016.x
    • Chen H, Kent S, Morris MJ (2006) Is the CCK2 receptor essential for normal regulation of body weight and adiposity? Eur J Neurosci 24:1427-1433 (Pubitemid 44401665)
    • (2006) European Journal of Neuroscience , vol.24 , Issue.5 , pp. 1427-1433
    • Chen, H.1    Kent, S.2    Morris, M.J.3
  • 27
    • 0027162490 scopus 로고
    • Neurobiological investigations into the role of cholecystokinin in panic disorder
    • Bradwejn J (1993) Neurobiological investigations into the role of cholecystokinin in panic disorder. J Psychiatry Neurosci 18:178-188 (Pubitemid 23255883)
    • (1993) Journal of Psychiatry and Neuroscience , vol.18 , Issue.4 , pp. 178-188
    • Bradwejn, J.1
  • 28
    • 26844477911 scopus 로고    scopus 로고
    • 2) receptor-mediated anxiety-like behaviors in rats
    • DOI 10.1016/j.neubiorev.2005.05.008, PII S0149763405001004
    • Wang H, Wong PT, Spiess J, Zhu YZ (2005) Cholecystokinin-2 (CCK2) receptor-mediated anxiety-like behaviors in rats. Neurosci Biobehav Rev 29:1361-1373 (Pubitemid 41446905)
    • (2005) Neuroscience and Biobehavioral Reviews , vol.29 , Issue.8 , pp. 1361-1373
    • Wang, H.1    Wong, P.T.-H.2    Spiess, J.3    Zhu, Y.Z.4
  • 29
    • 38349104637 scopus 로고    scopus 로고
    • Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients
    • 17597711 10.1038/sj.clpt.6100272 1:CAS:528:DC%2BD1cXitFKjtbk%3D
    • Jordan J, Greenway FL, Leiter LA, Li Z, Jacobson P, Murphy K et al (2008) Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients. Clin Pharmacol Ther 83:281-287
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 281-287
    • Jordan, J.1    Greenway, F.L.2    Leiter, L.A.3    Li, Z.4    Jacobson, P.5    Murphy, K.6
  • 30
    • 4344684441 scopus 로고    scopus 로고
    • Pharmacogenetics and drug development: The path to safer and more effective drugs
    • DOI 10.1038/nrg1432
    • Roses AD (2004) Pharmacogenetics and drug development: the path to safer and more effective drugs. Nat Rev Genet 5:645-656 (Pubitemid 39150121)
    • (2004) Nature Reviews Genetics , vol.5 , Issue.9 , pp. 645-656
    • Roses, A.D.1
  • 31
    • 62649127050 scopus 로고    scopus 로고
    • Stimulation of cholecystokinin-A receptors with Gl181771X a failed clinical trial that did not test the pharmacogenetic hypothesis for reduction of food intake
    • 19295535 10.1038/clpt.2008.192 1:CAS:528:DC%2BD1MXjtlSlsrk%3D
    • Roses AD (2009) Stimulation of cholecystokinin-A receptors with Gl181771X a failed clinical trial that did not test the pharmacogenetic hypothesis for reduction of food intake. Clin Pharmacol Ther 85:362-365
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 362-365
    • Roses, A.D.1
  • 32
    • 68949177102 scopus 로고    scopus 로고
    • Gut hormones: Implications for the treatment of obesity
    • 19560488 10.1016/j.pharmthera.2009.06.005 1:CAS:528:DC%2BD1MXhtVegsLvM
    • Neary MT, Batterham RL (2009) Gut hormones: implications for the treatment of obesity. Pharmacol Ther 124:44-56
    • (2009) Pharmacol Ther , vol.124 , pp. 44-56
    • Neary, M.T.1    Batterham, R.L.2
  • 34
    • 0018146832 scopus 로고
    • Inconsistency and possible habituation of CCK induced satiety
    • DOI 10.1016/0031-9384(78)90278-0
    • Mineka S, Snowdon CT (1978) Inconsistency and possible habituation of CCK-induced satiety. Physiol Behav 21:65-72 (Pubitemid 8380813)
    • (1978) Physiology and Behavior , vol.21 , Issue.1 , pp. 65-72
    • Mineka, S.1    Snowdon, C.T.2
  • 35
    • 0020522487 scopus 로고
    • Rapid development of tolerance to the behavioural actions of cholecystokinin
    • Crawley JN, Beinfeld MC (1983) Rapid development of tolerance to the behavioural actions of cholecystokinin. Nature 302:703-706 (Pubitemid 13120271)
    • (1983) Nature , vol.302 , Issue.5910 , pp. 703-706
    • Crawley, J.N.1    Beinfeld, M.C.2
  • 36
    • 0023353827 scopus 로고
    • Lithium chloride, cholecystokinin and meal patterns: Evidence that cholecystokinin suppresses meal size in rats without causing malaise
    • 2820304 10.1016/0195-6663(87)90021-3 1:CAS:528:DyaL1cXltFyh
    • West DB, Greenwood MR, Marshall KA, Woods SC (1987) Lithium chloride, cholecystokinin and meal patterns: evidence that cholecystokinin suppresses meal size in rats without causing malaise. Appetite 8:221-227
    • (1987) Appetite , vol.8 , pp. 221-227
    • West, D.B.1    Greenwood, M.R.2    Marshall, K.A.3    Woods, S.C.4
  • 37
    • 79961175481 scopus 로고    scopus 로고
    • The future of incretin-based therapy: Novel avenues-novel targets
    • 21824270 10.1111/j.1463-1326.2011.01457.x
    • Ahrén B (2011) The future of incretin-based therapy: novel avenues-novel targets. Diabetes Obes Metab 13(Suppl 1):158-166
    • (2011) Diabetes Obes Metab , vol.13 , Issue.SUPPL. 1 , pp. 158-166
    • Ahrén, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.