PTEN - Linking metabolism, cell growth, and cancer

New England Journal of Medicine

Volumn 367, Issue 11, 2012, Pages 1061-1063

  Smith, Ulf ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE RECEPTOR; INSULIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE;

BINDING AFFINITY; BINDING SITE; CANCER RISK; CELL GROWTH; CELL SURVIVAL; COWDEN SYNDROME; EDITORIAL; GENE; GENE MUTATION; HUMAN; INSULIN SENSITIVITY; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PTEN GENE; RECEPTOR BINDING; RISK ASSESSMENT; SIGNAL TRANSDUCTION;

EID: 84866071475     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMe1208934     Document Type: Editorial

References (9)

1. Smith U, Gale EA. Cancer and diabetes: are we ready for prime time? Diabetologia 2010;53:1541-4.
2. Giovannucci E, Harlan DM, Archer MC, et al. Diabetes and cancer: a consensus report. Diabetes Care 2010;33:1674-85.
3. Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 2008;8:915-28. [Erratum, Nat Rev Cancer 2009;9:224.]
4. Cohen DH, Leroith D. Obesity, type 2 diabetes and cancer: the insulin and insulin-like growth factor connection. Endocr Relat Cancer 2012 May 16 (Epub ahead of print).
5. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
6. Pal A, Barber TM, Van de Bunt M, et al. PTEN mutations as a cause of constitutive insulin sensitivity and obesity. N Engl J Med 2012;367:1002-11.
7. Alimonti A, Carracedo A, Clohessy JG, et al. Subtle variations in PTEN dose determine cancer susceptibility. Nat Genet 2010;42:454-8.
8. Garcia-Cao I, Song MS, Hobbs RM, et al. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell 2012;149:49-62.
9. Stiles B, Wang Y, Stahl A, et al. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity. Proc Natl Acad Sci U S A 2004;101:2082-7. [Erratum, Proc Natl Acad Sci U S A 2004;101:5180.]