Screening of the inhibitory effect of xenobiotics on alcohol metabolism using S9 rat liver fractions

Toxicology in Vitro

Volumn 26, Issue 7, 2012, Pages 1177-1180

  Dias, Catarina ^a   Testa, Bernard ^b   Soveral, Graça ^a,c   Dias, Mário ^d   Constantino, Luís ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^d INSTITUTO NACIONAL DE MEDICINA LEGAL E CIÊNCIAS FORENSES   (Portugal)

Author keywords

Alcohol dehydrogenase; Alprazolam; Cimetidine; Ethanol metabolism; Flunitrazepam; Tramadol

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL; ALCOHOL DEHYDROGENASE; ALPRAZOLAM; CIMETIDINE; FLUNITRAZEPAM; TRAMADOL;

ALCOHOL METABOLISM; ALCOHOLISM; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; LAW SUIT; LIVER; NONHUMAN; OUTCOME ASSESSMENT; PROTEIN INTERACTION; RAT;

ALCOHOL DEHYDROGENASE; ALPRAZOLAM; ANIMALS; CIMETIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; ETHANOL; FLUNITRAZEPAM; INHIBITORY CONCENTRATION 50; LIVER; PYRAZOLES; RATS; RATS, WISTAR; RIBOSOMAL PROTEINS; TRAMADOL; XENOBIOTICS;

RATTUS;

EID: 84866048147     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.06.011     Document Type: Article

References (26)

1. Battiston L., Tulissi P., Moretti M., Mazzoran L., Marchi P., Pussini E., Pozzato G. Hepatic glutathione after ethanol administration in rat: effects of cimetidine and omeprazole. Pharmacol. Res. 1995, 31:305-311.
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
3. Bychkov P.V., Shekhovtsova T.N., Milaeva E.R. Inhibition of horse liver alcohol dehydrogenase by methyltin compounds. Bioinorg. Chem. Appl. 2005, 3:191-199.
4. Cheung C., Davies N.G., Hoog J.-O., Hotchkiss S.A.M., Pease C.K.S. Species variations in cutaneous alcohol dehydrogenases and aldehyde dehydrogenases may impact on toxicological assessments of alcohols and aldehydes. Toxicology 2003, 184:97-112.
5. Cornell N.W., Hansch C., Kim K.H., Henegar K. The inhibition of alcohol dehydrogenase in vitro and in isolated hepatocytes by 4-substituted pyrazoles. Arch. Biochem. Biophys. 1983, 227(1):81-90.
6. Cunningham R.M., Bernstein S.L., Walton M., Broderick K., Vaca F.E., Woolard R., Bernstein E., Blow F., D'Onofrio G. Alcohol, tobacco, and other drugs: future directions for screening and intervention in the emergency department. Acad. Emerg. Med. 2009, 16(11):1078-1088. 10.1111/j.1553-2712.2009.00552.x.
7. Dawidek-Pietryka K., Szczepaniak S., Dudka J., Mazur M. In vitro studies of human alcohol dehydrogenase inhibition in the process of methanol and ethylene glycol oxidation. Arch. Toxicol. 1998, 72:604-607.
8. DRUID, 2011a. Prevalence of alcohol and other psychoactive substances in injured and killed drivers. Deliverable 2.2.5. DRUID 6th Framework Programme. Available at: http://www.druid-project.eu/cln_031/nn_107548/Druid/EN/deliverales-list/downloads/Deliverable__2__2__5,templateId=raw,property=publicationFile.pdf/Deliverable_2_2_5.pdf.
9. DRUID, 2011b. Prevalence of alcohol and other psychoactive substances in drivers in traffic in general in 13 countries - Part I. Deliverable 2.2.3. DRUID 6th Framework Programme. Available at: http://www.druid-project.eu/cln_031/nn_107548/Druid/EN/deliverales-list/downloads/Deliverable__2__2__3__Part1,templateId=raw,property=publicationFile.pdf/Deliverable_2_2_3_Part1.pdf.
10. DRUID, 2011c. Prevalence of Psychoactive Substances in the General Population. Deliverable 2.1.1. DRUID 6th Framework Programme. Available at: http://www.druid-project.eu/cln_031/nn_107548/Druid/EN/deliverales-list/downloads/Deliverable__2__1__1,templateId=raw,property=publicationFile.pdf/Deliverable_2_1_1.pdf.
11. EMCDDA, 2008. Drug use, impaired driving and traffic accidents, EMCDDA Insights series N 8, European Monitoring Centre for Drugs and Drug addiction, Lisbon. Available at: http://www.emcdda.europa.eu/publications/insights/driving.
12. Gergel D., Cederbaum A.I. Inhibition of the catalytic activity of alcohol dehydrogenase by nitric oxide is associated with S nitrosylation and the release of zinc. Biochemistry 1996, 35:16186-16194.
13. Holmes R.S. Opossum alcohol dehydrogenases: sequences, structures, phylogeny and evolution. Evidence for the tandem location of ADH genes on opossum chromosome 5. Chem. Biol. Interact. 2009, 178:8-15.
14. Höög J.O., Hedberg J.J., Strömberg P., Svensson S. Mammalian alcohol dehydrogenase - functional and structural implications. J. Biomed. Sci. 2001, 8(1):71-76.
15. Jin L., Szeto K.Y., Zhang L., Du W., Sun H. Inhibition of alcohol dehydrogenase by bismuth. J. Inorg. Biochem. 2004, 98:1331-1337.
16. Julià P., Farrés J., Parés X. Characterization of three isoenzymes of rat alcohol dehydrogenase. Tissue distribution and physical and enzymatic properties. Eur. J. Biochem. 1987, 62(1):179-189.
17. Kägi J.H.R., Vallee B.L. Metallothionein: a cadmium and zinc containing protein from equine renal cortex. J. Biol. Chem. 1960, 235:3188-3192.
18. Michaud K., Augsburger M., Romain N., Giroud C., Mangin P. Fatal overdose of tramadol and alprazolam. Forensic Sci. Int. 1999, 105:185-189.
19. Mirmiran-Yazdy S.A., Haber P.S., Korsten M.A., Mak K.M., Gentry R.T., Batra S.C., Lieber C.S. Metabolism of ethanol in rat gastric cells and its inhibition by cimetidine. Gastroenterology 1995, 108:737-742.
20. Moore K.A., Cina S.J., Jones R., Selby D.M., Levine B., Smith M.L. Tissue distribution of tramadol and metabolites in an overdose fatality. Am. J. Forensic Med. Pathol. 1999, 20(1):98-100.
21. Pozzato G., Stebel M., Lunazzi G., Moretti M., Franzin F. Influence of acid-secretion blockers on gastric and hepatic alcohol dehydrogenase in rat. Scand. J. Clin. Lab. Invest. 1992, 52:747-752.
22. Stone C.L., Hurley T.D., Peggs C.F., Kedishvili N.Y., Davis G.J., Thomasson H.R., Li T.-K., Bosron W.F. Cimetidine inhibition of human gastric and liver alcohol dehydrogenase isoenzymes: identification of inhibitor complexes by kinetics and molecular modeling. Biochemistry 1995, 34:4008-4014.
23. Tanaka E. Toxicological interactions between alcohol and benzodiazepines. Clin. Toxicol. 2002, 40(1):69-75.
24. Tanaka E., Nakamura T., Terada M., Shinozuka T., Honda K. Metabolic interaction between ethanol, high-dose alprazolam and its two main metabolites using human liver microsomes in vitro. J. Forensic Legal Med. 2007, 14:348-351.
25. Tanaka E., Nakamura T., Terada T., Shinozuka T., Honda K. Preliminary study of the in vitro interaction between alcohol, high-dose flunitrazepam and its three metabolites using human liver microsomes. Basic Clin. Pharmacol. Toxicol. 2005, 96:88-90.
26. Weathermon R., Crabb D.W. Alcohol and medication interactions. Alcohol Res. Health 1999, 23:40-54.