Phagocytic entry of Legionella pneumophila into macrophages through phosphatidylinositol 3,4,5-trisphosphate-independent pathway

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 9, 2012, Pages 1460-1468

  Harada, Toshihiko ^a   Tanikawa, Takashi ^a   Iwasaki, Yasunori ^a   Yamada, Masao ^a   Imai, Yasuyuki ^a   Miyake, Masaki ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Cytoskeleton; Legionella pneumophila; Macrophage; Phagocytosis; Phosphoinositide

Indexed keywords

FC RECEPTOR; IMMUNOGLOBULIN G; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; RAC1 PROTEIN;

ANIMAL CELL; ARTICLE; BACTERIUM MUTANT; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTERNALIZATION; LEGIONELLA PNEUMOPHILA; MACROPHAGE; MOUSE; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; PROTEIN LOCALIZATION; TYPE IV SECRETION SYSTEM; WILD TYPE;

EID: 84866036989     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b11-00011     Document Type: Article

References (28)

1. Swanson JA, Hoppe AD. The coordination of signaling during Fc receptor-mediated phagocytosis. J. Leukoc. Biol., 76, 1093-1103 (2004).
2. Marshall JG, Booth JW, Stambolic V, Mak T, Balla T, Schreiber AD, Meyer T, Grinstein S. Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fcγ receptor-mediated phagocytosis. J. Cell Biol., 153, 1369-1380 (2001).
3. Kamen LA, Levinsohn J, Swanson JA. Differential association of phosphatidylinositol 3-kinase, SHIP-1, and PTEN with forming phagosomes. Mol. Biol. Cell, 18, 2463-2472 (2007).
4. Lambeth JD. NOX enzymes and the biology of reactive oxygen. Nat. Rev. Immunol., 4, 181-189 (2004).
5. Kanai F, Liu H, Field SJ, Akbary H, Matsuo T, Brown GE, Cantley LC, Yaffe MB. The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat. Cell Biol., 3, 675-678 (2001).
6. Segal G, Feldman M, Zusman T. The Icm/Dot type-IV secretion systems of Legionella pneumophila and Coxiella burnetii. FEMS Microbiol. Rev., 29, 65-81 (2005).
7. Ninio S, Roy CR. Effector proteins translocated by Legionella pneumophila: strength in numbers. Trends Microbiol., 15, 372-380 (2007).
8. Ensminger AW, Isberg RR. Legionella pneumophila Dot/Icm translocated substrates: a sum of parts. Curr. Opin. Microbiol., 12, 67-73 (2009).
9. Hilbi H, Segal G, Shuman HA. Icm/dot-dependent upregulation of phagocytosis by Legionella pneumophila. Mol. Microbiol., 42, 603-617 (2001).
10. Khelef N, Shuman HA, Maxfield FR. Phagocytosis of wild-type Legionella pneumophila occurs through a wortmannin-insensitive pathway. Infect. Immun., 69, 5157-5161 (2001).
11. Harada T, Miyake M, Imai Y. Evasion of Legionella pneumophila from the bactericidal system by reactive oxygen species (ROS) in macrophages. Microbiol. Immunol., 51, 1161-1170 (2007).
12. Taniguchi T, Harada T, Hayashi T, Tanikawa T, Kurohane K, Miyake M, Imai Y. Elevated production of Legionella-specific immunoglobulin A in A/J mice is accompanied by T-helper 1-type polarization. Immunol. Lett., 121, 123-126 (2008).
13. Tanikawa T, Ishikawa T, Maekawa T, Kuronane K, Imai Y. Characterization of monoclonal immunoglobulin a and g against Shiga toxin binding subunits produced by intranasal immunization. Scand. J. Immunol., 68, 414-422 (2008).
14. Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem. J., 351, 19-31 (2000).
15. Hayashi T, Miyake M, Fukui T, Sugaya N, Daimon T, Itoh S, Oku T, Tsuji T, Toyoshima S, Imai Y. Exclusion of actin-binding protein p57/coronin-1 from bacteria-containing phagosomes in macrophages infected with Legionella. Biol. Pharm. Bull., 31, 861-865 (2008).
16. Saxena A, Morozov P, Frank D, Musalo R, Lemmon MA, Skolnik EY, Tycko B. Phosphoinositide binding by the pleckstrin homology domains of Ipl and Tih1. J. Biol. Chem., 277, 49935-49944 (2002).
17. Koyasu S. The role of PI3K in immune cells. Nat. Immunol., 4, 313-319 (2003).
18. Munugalavadla V, Borneo J, Ingram DA, Kapur R. p85α subunit of class IA PI-3 kinase is crucial for macrophage growth and migration. Blood, 106, 103-109 (2005).
19. Tachado SD, Samrakandi MM, Cirillo JD. Non-opsonic phagocytosis of Legionella pneumophila by macrophages is mediated by phosphatidylinositol 3-kinase. PLoS ONE, 3, e3324 (2008).
20. Charpentier X, Gabay JE, Reyes M, Zhu JW, Weiss A, Shuman HA. Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila. PLoS Pathog., 5, e1000501 (2009).
21. Peracino B, Balest A, Bozzaro S. Phosphoinositides differentially regulate bacterial uptake and Nramp1-induced resistance to Legionella infection in Dictyostelium. J. Cell Sci., 123, 4039-4051 (2010).
22. Brand BC, Sadosky AB, Shuman HA. The Legionella pneumophila icm locus: a set of genes required for intracellular multiplication in human macrophages. Mol. Microbiol., 14, 797-808 (1994).
23. Celli J, Olivier M, Finlay BB. Enteropathogenic Escherichia coli mediates antiphagocytosis through the inhibition of PI 3-kinase-dependent pathways. EMBO J., 20, 1245-1258 (2001).
24. Rudolph MG, Weise C, Mirold S, Hillenbrand B, Bader B, Wittinghofer A, Hardt WD. Biochemical analysis of SopE from Salmonella typhimurium, a highly efficient guanosine nucleotide exchange factor for RhoGTPases. J. Biol. Chem., 274, 30501-30509 (1999).
25. Bustelo XR. Regulatory and signaling properties of the Vav family. Mol. Cell. Biol., 20, 1461-1477 (2000).
26. Brombacher E, Urwyler S, Ragaz C, Weber SS, Kami K, Overduin M, Hilbi H. Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila. J. Biol. Chem., 284, 4846-4856 (2009).
27. Ragaz C, Pietsch H, Urwyler S, Tiaden A, Weber SS, Hilbi H. The Legionella pneumophila phosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication- permissive vacuole. Cell. Microbiol., 10, 2416-2433 (2008).
28. Weber SS, Ragaz C, Reus K, Nyfeler Y, Hilbi H. Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole. PLoS Pathog., 2, e46 (2006).