Upregulating CXCR4 in human fetal mesenchymal stem cells enhances engraftment and bone mechanics in a mouse model of osteogenesis imperfecta

Stem Cells Translational Medicine

Volumn 1, Issue 1, 2012, Pages 70-78

  Jones, Gemma N ^a   Moschidou, Dafni ^a   Lay, Kenneth ^a   Abdulrazzak, Hassan ^a   Vanleene, Maximilien ^a   Shefelbine, Sandra J ^a   Polak, Julia ^a   de Coppi, Paolo ^b   Fisk, Nicholas M ^c   Guillot, Pascale V ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

CXCR4; Fetal stem cells; Mesenchymal stem cells; Osteogenesis imperfecta; SDF1; Stem cell transplantation

Indexed keywords

BETA ACTIN; CHEMOKINE RECEPTOR CXCR4; STROMAL CELL DERIVED FACTOR 1; ALPHA 2(I) COLLAGEN; COLLAGEN TYPE 1; CXCR4 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CULTURE; BONE MARROW CELL; CHEMOTAXIS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENGRAFTMENT; FETUS BLOOD; FIRST TRIMESTER PREGNANCY; FLOW CYTOMETRY; FRACTURE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOGENESIS IMPERFECTA; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; BONE MATRIX; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; DISEASE MODEL; FEMALE; GENETICS; IMMUNOLOGY; MALE; MESENCHYMAL STROMA CELL; METABOLISM; MOUSE MUTANT; OSTEOBLAST; PATHOLOGY; TIME; TRANSPLANTATION; UPREGULATION;

ANIMALS; BONE MATRIX; CELL DIFFERENTIATION; CELLS, CULTURED; CHEMOKINE CXCL12; CHEMOTAXIS; COLLAGEN TYPE I; DISEASE MODELS, ANIMAL; FEMALE; FRACTURES, BONE; HUMANS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OSTEOBLASTS; OSTEOGENESIS IMPERFECTA; RECEPTORS, CXCR4; TIME FACTORS; UP-REGULATION;

EID: 84866029910     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2011-0007     Document Type: Article

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