Induction of 1-acylglycerophosphocholine acyltransferase genes by fibrates in the liver of rats

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 9, 2012, Pages 1509-1515

  Yamazaki, Tohru ^a   Wakabayashi, Michiko ^a   Ikeda, Erika ^a   Tanaka, Shizuyo ^a   Sakamoto, Takeshi ^a   Mitsumoto, Atsushi ^b   Kudo, Naomi ^a   Kawashima, Yoichi ^a  

^a JOSAI UNIVERSITY   (Japan)

^b JOSAI INTERNATIONAL UNIVERSITY   (Japan)

Author keywords

1 acylglycerophosphocholine acyltransferase; Bezafibrate; Clofibric acid; Fenofibrate; Rat liver

Indexed keywords

1 ACYLGLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE; 1 ACYLGLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1; 1 ACYLGLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 2; 1 ACYLGLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 3; 1 ACYLGLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 4; ACYL COENZYME A DESATURASE 1; ARACHIDONOYL COENZYME A; BEZAFIBRATE; CLOFIBRIC ACID; COENZYME A; FENOFIBRATE; FIBRIC ACID DERIVATIVE; LINOLEOYL COENZYME A; LINOLEOYL COENZYME A DESATURASE; MESSENGER RNA; PHOSPHATIDYLCHOLINE; UNCLASSIFIED DRUG;

1 ACYLGLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE GENE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE INDUCTION; LIPID COMPOSITION; LIVER; LIVER MICROSOME; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; UPREGULATION;

EID: 84866019894     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00243     Document Type: Article

References (28)

1. Lazarow PB, De Duve C. A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug. Proc. Natl. Acad. Sci. U.S.A., 73, 2043-2046 (1976).
2. Kawashima Y, Kozuka H, Matsumura M, Kozuka H. Increased activity of stearoyl-CoA desaturation in liver from rat fed clofibric acid. Biochim. Biophys. Acta, 713, 622-628 (1982).
3. Toyama T, Kudo N, Mitsumoto A, Hibino Y, Tsuda T, Kawashima Y. Stearoyl-CoA desaturase activity is elevated by the suppression of its degradation by clofibric acid in the liver of rats. J. Pharmacol. Sci., 103, 383-390 (2007).
4. Kawashima Y, Kozuka H. Regulation of palmitoyl-CoA chain elongation and linoleoyl-CoA chain elongation in rat liver microsomes and the differential effects of peroxisome proliferators, insulin and thyroid hormone. Biochim. Biophys. Acta, 834, 118-123 (1985).
5. Kawashima Y, Hirose A, Kozuka H. Modification by clofibric acid of acyl composition of glycerolipids in rat liver. Possible involvement of fatty acid chain elongation and desaturation. Biochim. Biophys. Acta, 795, 543-551 (1984).
6. Das AK, Aquilina JW, Hajra AK. The rapid induction of liver glycerophosphate acyltransferase in mice by clofibrate, a hypolipidemic agent. J. Biol. Chem., 258, 3090-3093 (1983).
7. Yamashita A, Sato K, Watanabe M, Tokudome Y, Sugiura T, Waku K. Induction of coenzyme A-dependent transacylation activity in rat liver microsomes by administration of clofibrate. Biochim. Biophys. Acta, 1211, 263-269 (1994).
8. Kawashima Y, Hirose A, Kozuka H. Selective increase in acylation of 1-acylglycerophosphorylcholine in livers of rats and mice by peroxisome proliferators. Biochim. Biophys. Acta, 793, 232-237 (1984).
9. Kawashima Y, Horii S, Matsunaga T, Hirose A, Adachi T, Kozuka H. Co-induction by peroxisome proliferators of microsomal 1- acylglycerophosphocholine acyltransferase with peroxisomal β-oxidation in rat liver. Biochim. Biophys. Acta, 1005, 123-129 (1989).
10. Lands WEM, Merkl I. Metabolism of glycerolipids. III. Reactivity of various acyl esters of coenzyme A with α′- acylglycerophosphorylcholine, and positional specificities in lecithin synthesis. J. Biol. Chem., 238, 898-904 (1963).
11. Mizuguchi H, Kudo N, Kawashima Y. Metabolic alterations by clofibric acid in the formation of molecular species of phosphatidylcholine in rat liver. Biochem. Pharmacol., 62, 853-861 (2001).
12. Kawashima Y, Hirose A, Adachi T, Kozuka H. Role of stearoyl-CoA desaturase and 1-acylglycerophosphorylcholine acyltransferase in the regulation of the acyl composition of phosphatidylcholine in rat liver. Biochim. Biophys. Acta, 837, 222-229 (1985).
13. Mizuguchi H, Kudo N, Kawashima Y. Role of stearoyl-CoA desaturase in the modification of acyl composition of hepatic phosphatidylcholine by peroxisome proliferators. Biol. Pharm. Bull., 19, 1556-1559 (1996).
14. Imai K, Koyama M, Kudo N, Shirahata A, Kawashima Y. Increase in hepatic content of oleic acid induced by dehydroepiandrosterone in the rat. Biochem. Pharmacol., 58, 925-933 (1999).
15. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275 (1951).
16. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol., 37, 911-917 (1959).
17. Zhao Y, Chen Y-Q, Bonacci TM, Bredt DS, Li S, Bensch WR, Moller DE, Kowala M, Konrad RJ, Cao G. Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. J. Biol. Chem., 283, 8258-8265 (2008).
18. Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, Taguchi R, Shimizu T. Cloning and characterization of mouse lung-type acyl-CoA : lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production. J. Biol. Chem., 281, 20140-20147 (2006).
19. Chen X, Hyatt BA, Mucenski ML, Mason RJ, Shannon JM. Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells. Proc. Natl. Acad. Sci. U.S.A., 103, 11724-11729 (2006).
20. Shindou H, Hishikawa D, Nakanishi H, Harayama T, Ishii S, Taguchi R, Shimizu T. A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA : LYSO-PAF acetyltransferase. J. Biol. Chem., 282, 6532-6539 (2007).
21. Hishikawa D, Shindou H, Kobayashi S, Nakanishi H, Taguchi R, Shimizu T. Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc. Natl. Acad. Sci. U.S.A., 105, 2830-2835 (2008).
22. Yamazaki T, Hirose A, Sakamoto T, Okazaki M, Mitsumoto A, Kudo N, Kawashima Y. Peroxisome proliferators attenuate free arachidonic acid pool in the kidney through inducing lysophospholipid acyltransferases. J. Pharmacol. Sci., 111, 201-210 (2009).
23. Hashimoto T, Cook WS, Qi C, Yeldandi AV, Reddy JK, Rao MS. Defect in peroxisome proliferator-activated receptor α-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J. Biol. Chem., 275, 28918-28928 (2000).
24. Lands WEM. Stories about acyl chains. Biochim. Biophys. Acta, 1483, 1-14 (2000).
25. Yamazaki T, Okada H, Sakamoto T, Sunaga K, Tsuda T, Mitsumoto A, Kudo N, Kawashima Y. Differential induction of stearoyl-CoA desaturase 1 and 2 genes by fibrates in the liver of rats. Biol. Pharm. Bull., 35, 116-120 (2012).
26. Hirose A, Yamazaki T, Sakamoto T, Sunaga K, Tsuda T, Mitsumoto A, Kudo N, Kawashima Y. Clofibric acid increases the formation of oleic acid in endoplasmic reticulum of the liver of rats. J. Pharmacol. Sci., 116, 362-372 (2011).
27. Marcel YL, Christiansen K, Holman RT. The preferred metabolic pathway from linoleic acid to arachidonic acid in vitro. Biochim. Biophys. Acta, 164, 25-34 (1968).
28. Ariyama H, Kono N, Matsuda S, Inoue T, Arai H. Decrease in membrane phospholipid unsaturation induces unfolded protein response. J. Biol. Chem., 285, 22027-22035 (2010).