Stearoyl-CoA desaturase activity is elevated by the suppression of its degradation by clofibric acid in the liver of rats

Journal of Pharmacological Sciences

Volumn 103, Issue 4, 2007, Pages 383-390

  Toyama, Tomoaki ^a   Kudo, Naomi ^a   Mitsumoto, Atsushi ^b   Hibino, Yasuhide ^a   Tsuda, Tadashi ^a   Kawashima, Yoichi ^a,b  

^a JOSAI UNIVERSITY   (Japan)

^b JOSAI INTERNATIONAL UNIVERSITY   (Japan)

Author keywords

Clofibric acid; Palmitoyl CoA chain elongase; Protein degradation; Stearoyl CoA desaturase

Indexed keywords

ACYL COENZYME A DESATURASE; CLOFIBRIC ACID; MESSENGER RNA; OLEIC ACID; PALMITOYL COENZYME A; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME REGULATION; FOOD INTAKE; LIVER METABOLISM; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; RNA TRANSCRIPTION; STEADY STATE; TRANSCRIPTION INITIATION;

EID: 34247400321     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FP0061124     Document Type: Article

References (37)

1. Rubins HB, Robins SJ, Collins D, Fye CL, Anderson JW, Elam MB, et al. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med. 1999;341:410-418.
2. Rubins HB, Robins SJ, Collins D, Nelson DB, Elam MB, Schaefer EJ, et al. Diabetes, plasma insulin, and cardiovascular disease: subgroup analysis from the Department of Veterans Affairs high-density lipoprotein intervention trial (VA-HIT). Arch Intern Med. 2002;162:2597-2604.
3. Tenenbaum A, Motro M, Fisman EZ, Tanne D, Boyko V, Behar S. Bezafibrate for the secondary prevention of myocardial infarction in patients with metabolic syndrome. Arch Intern Med. 2005;165:1154-1160.
4. Fruchart JC, Brewer HB Jr, Leitersdorf E. Consensus for the use of fibrates in the treatment of dyslipoproteinemia and coronary heart disease. Fibrate Consensus Group. Am J Cardiol. 1998;81:912-917.
5. Kockx M, Gervois PP, Poulain P, Derudas B, Peters JM, Gonzalez FJ, et al. Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-alpha. Blood. 1999;93:2991-2998.
6. Wang TD, Chen WJ, Lin JW, Cheng CC, Chen MF, Lee YT. Efficacy of fenofibrate and simvastatin on endothelial function and inflammatory markers in patients with combined hyperlipidemia: relations with baseline lipid profiles. Atherosclerosis. 2003;170:315-323.
7. Cohen P, Miyazaki M, Socci ND, Hagge-Greenberg A, Liedtke W, Soukas AA, et al. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science. 2002;297:240-243.
8. Falvella FS, Pascale RM, Gariboldi M, Manenti G, De Miglio MR, Simile MM, et al. Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats. Carcinogenesis. 2002;23:1933-1936.
9. Kudo N, Toyama T, Mitsumoto A, Kawashima Y. Regulation by carbohydrate and clofibric acid of palmitoyl-CoA chain elongation in the liver of rats. Lipids. 2003;38:531-537.
10. Toyama T, Kudo N, Mitsumoto A, Kawashima Y. Regulation of palmitoyl-CoA chain elongation by clofibric acid in the liver of Zucker fa/fa rats. Lipids. 2005;40:463-470.
11. Imai K, Kudo N, Koyama M, Kawashima Y. Effects of dehydroepiandrosterone on oleic acid accumulation in rat liver. Biochem Pharmacol. 2003;65:1583-1591.
12. Kawashima Y, Kozuka H. Increased activity of stearoyl-CoA desaturation in liver from rat fed clofibric acid. Biochim Biophys Acta. 1982;713:622-628.
13. Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev. 1999;20:649-688.
14. Thiede MA, Ozols J, Strittmatter P. Construction and sequence of cDNA for rat liver stearyl coenzyme A desaturase. J Biol Chem. 1986;261:13230-13235.
15. Kaestner KH, Ntambi JM, Kelly TJ Jr, Lane MD. Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase. J Biol Chem. 1989;264:14755-14761.
16. Zheng Y, Prouty SM, Harmon A, Sundberg JP, Stenn KS, Parimoo S. Scd3 - a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin. Genomics. 2001;71:182-191.
17. Miyazaki M, Jacobson MJ, Man WC, Cohen P, Asilmaz E, Friedman JM, et al. Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. J Biol Chem. 2003;278:33904-33911.
18. Miller CW, Ntambi JM. Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression. Proc Natl Acad Sci U S A. 1996;93:9443-9448.
19. Sato O, Kuriki C, Fukui Y, Motojima K. Dual promoter structure of mouse and human fatty acid translocase/CD36 genes and unique transcriptional activation by peroxisome proliferator-activated receptor alpha and gamma ligands. J Biol Chem. 2002;277:15703-15711.
20. Hsu MH, Savas U, Griffin KJ, Johnson EF. Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells. J Biol Chem. 2001;276:27950-27958.
21. Lefevre P, Tripon E, Plumelet C, Douaire M, Diot C. Effects of polyunsaturated fatty acids and clofibrate on chicken stearoylcoA desaturase 1 gene expression. Biochem Biophys Res Commun. 2001;280:25-31.
22. Jeffcoat R. The biosynthesis of unsaturated fatty acids and its control in mammalian liver. Essays Biochem. 1979;15:1-36.
23. Kawashima Y, Suzuki Y, Hashimoto Y. Dietary control of the chain elongation of palmityl-CoA in rat liver microsomes. Lipids. 1977;12:434-437.
24. Cinti DL, Cook L, Nagi MN, Suneja SK. The fatty acid chain elongation system of mammalian endoplasmic reticulum. Prog Lipid Res. 1992;31:1-51.
25. Wang Y, Botolin D, Christian B, Busik J, Xu J, Jump DB. Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases. J Lipid Res. 2005;46:706-715.
26. Toyama T, Kudo N, Mitsumoto A, Kawashima Y. Effects of perfluorocarboxylic acids on the activities of acyl-CoA elongations in vivo and in vitro. Chem Biol Interact. 2004;150:189-198.
27. Oshino N, Sato R. The dietary control of the microsomal stearyl CoA desaturation enzyme system in rat liver. Arch Biochem Biophys. 1972;149:369-377.
28. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-275.
29. 5 in fatty acid desaturation by rat liver microsomes. J Biochem (Tokyo). 1971;69:155-167.
30. 5 and its implication to fatty acid desaturation. J Biochem (Tokyo). 1971;69:169-180.
31. Gorski K, Carneiro M, Schibler U. Tissue-specific in vitro transcription from the mouse albumin promoter. Cell. 1986;47:767-776.
32. Zhang J, Chrysis D, Underwood LE. Reduction of hepatic insulin-like growth factor I (IGF-I) messenger ribonucleic acid (mRNA) during fasting is associated with diminished splicing of IGF-I pre-mRNA and decreased stability of cytoplasmic IGF-I mRNA. Endocrinology. 1998;139:4523-4530.
33. Ichihara K. Statistics for bioscience. Practical technique and theory. Tokyo: Nankodo Co., Ltd.; 1990.
34. Inagaki K, Aki T, Fukuda Y, Kawamoto S, Shigeta S, Ono K, et al. Identification and expression of a rat fatty acid elongase involved in the biosynthesis of C18 fatty acids. Biosci Biotechnol Biochem. 2002;66:613-621.
35. Schimke RT, Doyle D. Control of enzyme levels in animal tissues. Annu Rev Biochem. 1970;39:929-976.
36. Heinemann FS, Ozols J. Stearoyl-CoA desaturase, a short-lived protein of endoplasmic reticulum with multiple control mechanisms. Prostaglandins Leukot Essent Fatty Acids. 2003;68:123-133.
37. Heinemann FS, Korza G, Ozols J. A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomes. J Biol Chem. 2003;278:42966-42975.