Erectile Dysfunction and Cardiovascular Events in Diabetic Men: A Meta-analysis of Observational Studies

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Yamada, Tomohide ^a   Hara, Kazuo ^a   Umematsu, Hitomi ^a   Suzuki, Ryo ^a   Kadowaki, Takashi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN A1C;

AGE; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; COCHRANE LIBRARY; COHORT ANALYSIS; CONFIDENCE INTERVAL; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE DURATION; ERECTILE DYSFUNCTION; HUMAN; INTERVIEW; ISCHEMIC HEART DISEASE; MEDLINE; OBSERVATIONAL STUDY; PERIPHERAL VASCULAR DISEASE; QUESTIONNAIRE; REGRESSION ANALYSIS; RISK ASSESSMENT; SYSTEMATIC ERROR; SYSTEMATIC REVIEW;

ADULT; AGED; CARDIOVASCULAR DISEASES; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DATABASES, BIBLIOGRAPHIC; DIABETES COMPLICATIONS; DIABETES MELLITUS; ERECTILE DYSFUNCTION; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; PREVALENCE; QUESTIONNAIRES; RISK FACTORS;

EID: 84866010388     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043673     Document Type: Article

References (40)

1. Gu k, Cowie CC, Harris MI, (1999) Diabetes and decline in heart disease mortality in US adults. JAMA 281: 1291-1297.
2. NIH Consensus Conference (1993) Impotence. NIH Consensus Development Panel on Impotence. JAMA 270: 83-90.
3. Giuliano FA, Leriche A, Jaudinot EO, de Gendre AS, (2004) Prevalence of erectile dysfunction among 7,689 patients with diabetes or hypertension, or both. Urology 64: 1196-1201.
4. Cho NH, Ahn CW, Park JY, Ahn TY, Lee HW, et al. (2006) Prevalence of erectile dysfunction in Korean men with Type 2 diabetes mellitus. Diabet Med 23: 198-203.
5. Romeo JH, Seftel AD, Madhun ZT, Aron DC, (2000) Sexual function in men with diabetes type 2: association with glycemic control. J Urol 163: 788-791.
6. Sasaki H, Yamasaki H, Ogawa K, Nanjo K, Kawamori R, et al. (2005) Prevalence and risk factors for erectile dysfunction in Japanese diabetics. Diabetes Res Clin Pract 70: 81-89.
7. Kalter-Leibovici O, Wainstein J, Ziv A, Harman-Bohem I, Murad H, et al. (2005) Israel Diabetes Research Group (IDRG) Investigators Clinical, socioeconomic, and lifestyle parameters associated with erectile dysfunction among diabetic men. Diabetes Care 28: 1739-1744.
8. Thompson IM, Tangen CM, Goodman PJ, Probstfield JL, Moinpour CM, et al. (2005) Erectile dysfunction and subsequent cardiovascular disease. JAMA 294: 2996-3002.
9. Frantzen J, Speel TG, Kiemeney LA, Meuleman EJ, (2006) Cardiovascular risk among men seeking help for erectile dysfunction. Ann Epidemiol 16: 85-90.
10. Dong JY, Zhang YH, Qin LQ, (2011) Erectile dysfunction and risk of cardiovascular disease: meta-analysis of prospective cohort studies. J Am Coll Cardiol 58: 1378-1385.
11. Guo W, Liao C, Zou Y, Li F, Li T, et al. (2010) Erectile dysfunction and risk of clinical cardiovascular events: a meta-analysis of seven cohort studies. J Sex Med 7: 2805-2816.
12. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, et al. (2008) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol 61: 344-349.
13. Higgins JP, Thompson SG, (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21: 1539-1558.
14. Duval S, Tweedie R, (2000) Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56: 455-463.
15. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, et al. (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 283: 2008-2012.
16. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, et al. (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med 151: W65-94.
17. Batty GD, Li Q, Czernichow S, Neal B, Zoungas S, et al. (2010) Erectile dysfunction and later cardiovascular disease in men with type 2 diabetes: prospective cohort study based on the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation) trial. J Am Coll Cardiol 56: 1908-1913.
18. Ma RC, So WY, Yang X, Yu LW, Kong AP, et al. (2008) Erectile dysfunction predicts coronary heart disease in type 2 diabetes. J Am Coll Cardiol 51: 2045-2050.
19. Gazzaruso C, Solerte SB, Pujia A, Coppola A, Vezzoli M, et al. (2008) Erectile dysfunction as a predictor of cardiovascular events and death in diabetic patients with angiographically proven asymptomatic coronary artery disease: a potential protective role for statins and 5-phosphodiesterase inhibitors. J Am Coll Cardiol 51: 2040-2044.
20. Klein R, Klein BE, Lee KE, Moss SE, Cruickshanks KJ, (1996) Prevalence of self-reported erectile dysfunction in people with long-term IDDM. Diabetes Care 19: 135-141.
21. Fedele D, Bortolotti A, Coscelli C, Santeusanio F, Chatenoud L, et al. (2000) Erectile dysfunction in type 1 and type 2 diabetics in Italy. On behalf of Gruppo Italiano Studio Deficit Erettile nei Diabetici. Int J Epidemiol 29: 524-531.
22. De Berardis G, Pellegrini F, Franciosi M, Belfiglio M, Di Nardo B, et al. (2005) Longitudinal assessment of quality of life in patients with type 2 diabetes and self-reported erectile dysfunction. Diabetes Care 28: 2637-2643.
23. Shiri R, Ansari M, Falah Hassani K, (2006) Association between comorbidity and erectile dysfunction in patients with diabetes. Int J Impot Res 18: 348-353.
24. Gazzaruso C, Pujia A, Solerte SB, Amici ED, Emanuele E, et al. (2006) Erectile dysfunction and angiographic extent of coronary artery disease in type II diabetic patients. Int J Impot Res 18: 311-315.
25. Yu LW, Kong AP, Tong PC, Tam C, Ko GT, et al. (2010) Evaluation of erectile dysfunction and associated cardiovascular risk using structured questionnaires in Chinese type 2 diabetic men. Int J Androl 33: 853-860.
26. Gazzaruso C, Coppola A, Montalcini T, Valenti C, Garzaniti A, et al. (2011) Erectile dysfunction can improve the effectiveness of the current guidelines for the screening for asymptomatic coronary artery disease in diabetes. Endocrine 40: 273-279.
27. García-Malpartida K, Mármol R, Jover A, Gómez-Martínez MJ, Solá-Izquierdo E, et al. (2011) Relationship between erectile dysfunction and silent myocardial ischemia in type 2 diabetic patients with no known macrovascular complications. J Sex Med 8: 2606-2616.
28. Gazzaruso C, Giordanetti S, De Amici E, Bertone G, Falcone C, et al. (2004) Relationship between erectile dysfunction and silent myocardial ischemia in apparently uncomplicated type 2 diabetic patients. Circulation 110 (1) pp. 22-26.
29. Andersson KE, Wagner G, (1995) Physiology of penile erection. Physiol Rev 75: 191-236.
30. Montorsi P, Ravagnani PM, Galli S, Rotatori F, Briganti A, et al. (2005) The artery size hypothesis: a macrovascular link between erectile dysfunction and coronary artery disease. Am J Cardiol 96: 19M-23M.
31. Kirby M, Jackson G, Simonsen U, (2005) Endothelial dysfunction links erectile dysfunction to heart disease. Int J Clin Pract 59: 225-229.
32. Vlachopoulos C, Ioakeimidis N, Terentes-Printzios D, Stefanadis C, (2008) The triad: erectile dysfunction-endothelial dysfunction-cardiovascular disease. Curr Pharm Des 14: 3700-3714.
33. Kaiser DR, Billups K, Mason C, Wetterling R, Lundberg JL, et al. (2004) Impaired brachial artery endothelium-dependent and-independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease. J Am Coll Cardiol 43: 179-184.
34. Vinik AI, Maser RE, Mitchell BD, Freeman R, (2003) Diabetic autonomic neuropathy. Diabetes Care 26 (5): 1553-1579.
35. Wackers FJ, Young LH, Inzucchi SE, Chyun DA, Davey JA, et al. (2004) Detection of Ischemia in Asymptomatic Diabetics Investigators. Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study. Diabetes Care 27: 1954-1961.
36. Young LH, Wackers FJ, Chyun DA, Davey JA, Barrett EJ, et al. (2009) Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial. JAMA 301: 1547-1555.
37. McEvoy JW, Blaha MJ, Nasir K, Yoon YE, Choi EK, et al. (2011) Impact of coronary computed tomographic angiography results on patient and physician behavior in a low-risk population. Arch Intern Med 171: 1260-1268.
38. Bhatt DL, Eagle KA, Ohman EM, Hirsch AT, Goto S, et al. (2010) Comparative determinants of 4-year cardiovascular event rates in stable outpatients at risk of or with atherothrombosis. JAMA 304: 1350-1357.
39. Qureshi N, Armstrong S, Dhiman P, Saukko P, Middlemass J, et al. (2012) Effect of adding systematic family history enquiry to cardiovascular disease risk assessment in primary care: a matched-pair, cluster randomized trial. Ann Intern Med 156: 253-262.
40. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, et al. (1997) The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 49: 822-830.