L-glutamine is a key parameter in the immunosuppression phenomenon

Biochemical and Biophysical Research Communications

Volumn 425, Issue 4, 2012, Pages 724-729

  Hammami, Ines ^a   Chen, Jingkui ^a   Bronte, Vincenzo ^b   DeCrescenzo, Gregory ^a   Jolicoeur, Mario ^a  

^a ÉCOLE POLYTECHNIQUE DE MONTRÉAL   (Canada)

^b UNIVERSITY OF VERONA   (Italy)

Author keywords

Bioenergetics; Immunosuppression; L Glutamine; MSC 1 cells; Myeloid derived suppressor cells; Nutritional profile

Indexed keywords

2 OXOGLUTARIC ACID; ARGINASE 1; FUMARIC ACID; GLUTAMINE; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL CELL; ARTICLE; BIOENERGY; CARBON METABOLISM; CELL ENERGY; CELL FUNCTION; CELL GROWTH; CELL IMMORTALIZATION; CELL METABOLISM; CELL VIABILITY; CITRIC ACID CYCLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; IMMUNOMODULATION; IMMUNOTHERAPY; LEUKEMIA CELL LINE; MOUSE; MYELOID DERIVED SUPPRESSOR CELL; NONHUMAN; PRIORITY JOURNAL; SUPPRESSOR CELL; TUMOR ESCAPE;

ANIMALS; ARGINASE; CELL LINE; CITRIC ACID CYCLE; ENERGY METABOLISM; GLUTAMINE; HUMANS; IMMUNE TOLERANCE; IMMUNOSUPPRESSION; JURKAT CELLS; MICE; MYELOID CELLS; NITRIC OXIDE SYNTHASE TYPE II; TUMOR ESCAPE;

EID: 84865980463     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.07.139     Document Type: Article

References (32)

1. Gabrilovich D.I., Bronte V., Chen S.H., Colombo M.P., Ochoa A., Ostrand-Rosenberg S., Schreiber H. The terminology issue for myeloid-derived suppressor cells. Cancer Res. 2007, 67:425. author reply 426.
2. Mori M. Regulation of nitric oxide synthesis and apoptosis by arginase and arginine recycling. J. Nutr. 2007, 137:1616S-1620S.
3. Rodriguez P.C., Ochoa A.C. Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives. Immunol. Rev. 2008, 222:180-191.
4. Bronte V., Serafini P., Mazzoni A., Segal D.M., Zanovello P. l-arginine metabolism in myeloid cells controls T-lymphocyte functions. Trends Immunol. 2003, 24:301-305.
5. I. Hammami, J. Chen, F. Murschel, V. Bronte, G. De Crescenzo, M. Jolicoeur, Immunosuppressive activity enhances central carbon metabolism and bioenergetics in myeloid-derived suppressor cells' in vitro models. BMC Cell Biology 13 (2012) 18.
6. Daye D., Wellen K.E. Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis. Semin. Cell Dev. Biol. 2012.
7. Roth E. Nonnutritive effects of glutamine. J. Nutr. 2008, 138:2025S-2031S.
8. Apolloni E., Bronte V., Mazzoni A., Serafini P., Cabrelle A., Segal D.M., Young H.A., Zanovello P. Immortalized myeloid suppressor cells trigger apoptosis in antigen-activated T lymphocytes. J. Immunol. 2000, 165:6723-6730.
9. Mazzoni A., Bronte V., Visintin A., Spitzer J.H., Apolloni E., Serafini P., Zanovello P., Segal D.M. Myeloid suppressor lines inhibit T cell responses by an NO-dependant mechanism. J. Immunol. 2002, 168:689-695.
10. Hammami I., Chen J., Bronte V., De Crescenzo G., Jolicoeur M. Myeloid-derived suppressor cells exhibit two bioenergetic steady-states in vitro. J. Biotechnol. 2011, 152:43-48.
11. Munder M., Eichmann K., Moran J.M., Centeno F., Soler G., Modolell M. Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells. J. Immunol. 1999, 163:3771-3777.
12. Lamboursain L., St-Onge F., Jolicoeur M. A lab-respirometer for plant and animal cell culture. Biotechnol. Prog. 2002, 18:1377-1386.
13. Kimball E., Rabinowitz J.D. Identifying decomposition products in extracts of cellular metabolites. Anal. Biochem. 2006, 358:273-280.
14. Serafini P., Borrello I., Bronte V. Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression. Semin. Cancer Biol. 2006, 16:53-65.
15. Rodriguez P.C., Ochoa A.C. T cell dysfunction in cancer: role of myeloid cells and tumor cells regulating amino acid availability and oxidative stress. Semin. Cancer Biol. 2006, 16:66-72.
16. J.G. Reich, E.E. Sel'Kov, Energy Metabolism of the Cell - A Theoritical Treatise, London, 1981.
17. Cidad P., Almeida A., Bolanos J.P. Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5'-AMP-activated protein kinase. Biochem. J. 2004, 384:629-636.
18. Murphy C., Newsholme P. Importance of glutamine metabolism in murine macrophages and human monocytes to l-arginine biosynthesis and rates of nitrite or urea production. Clin. Sci. (Lond) 1998, 95:397-407.
19. Costa Rosa L.F., Curi R., Murphy C., Newsholme P. Effect of adrenaline and phorbol myristate acetate or bacterial lipopolysaccharide on stimulation of pathways of macrophage glucose, glutamine and O2 metabolism. Evidence for cyclic AMP-dependent protein kinase mediated inhibition of glucose-6-phosphate dehydrogenase and activation of NADP+-dependent 'malic' enzyme. Biochem. J. 1995, 310(Pt 2):709-714.
20. Lu J., Wang X.Y., Tang W.H. Glutamine attenuates nitric oxide synthase expression and mitochondria membrane potential decrease in interleukin-1beta-activated rat hepatocytes. Eur. J. Nutr. 2009, 48:333-339.
21. Marion R., Coeffier M., Leplingard A., Favennec L., Ducrotte P., Dechelotte P. Cytokine-stimulated nitric oxide production and inducible NO-synthase mRNA level in human intestinal cells: lack of modulation by glutamine. Clin. Nutr. 2003, 22:523-528.
22. Wu G., Haynes T.E., Li H., Yan W., Meininger C.J. Glutamine metabolism to glucosamine is necessary for glutamine inhibition of endothelial nitric oxide synthesis. Biochem. J. 2001, 353:245-252.
23. Brasse-Lagnel C., Fairand A., Lavoinne A., Husson A. Glutamine stimulates argininosuccinate synthetase gene expression through cytosolic O-glycosylation of Sp1 in Caco-2 cells. J. Biol. Chem. 2003, 278:52504-52510.
24. Irace C., Esposito G., Maffettone C., Rossi A., Festa M., Iuvone T., Santamaria R., Sautebin L., Carnuccio R., Colonna A. Oxalomalate affects the inducible nitric oxide synthase expression and activity. Life Sci. 2007, 80:1282-1291.
25. Lemons J.M., Feng X.J., Bennett B.D., Legesse-Miller A., Johnson E.L., Raitman I., Pollina E.A., Rabitz H.A., Rabinowitz J.D., Coller H.A. Quiescent fibroblasts exhibit high metabolic activity. PLoS Biol. 2010, 8:e1000514.
26. Davidson G.S., Joe R.M., Roy S., Meirelles O., Allen C.P., Wilson M.R., Tapia P.H., Manzanilla E.E., Dodson A.E., Chakraborty S., Carter M., Young S., Edwards B., Sklar L., Werner-Washburne M. The proteomics of quiescent and nonquiescent cell differentiation in yeast stationary-phase cultures. Mol. Biol. Cell 2011, 22:988-998.
27. Clementi E., Brown G.C., Feelisch M., Moncada S. Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc. Natl. Acad. Sci. USA 1998, 95:7631-7636.
28. Corzo C.A., Condamine T., Lu L., Cotter M.J., Youn J.I., Cheng P., Cho H.I., Celis E., Quiceno D.G., Padhya T., McCaffrey T.V., McCaffrey J.C., Gabrilovich D.I. HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J. Exp. Med. 2010, 207:2439-2453.
29. Raghunand N., Gatenby R.A., Gillies R.J. Microenvironmental and cellular consequences of altered blood flow in tumours. Br. J. Radiol. 2003, 76(Spec No 1):S11-22.
30. Koivunen P., Hirsila M., Remes A.M., Hassinen I.E., Kivirikko K.I., Myllyharju J. Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J. Biol. Chem. 2007, 282:4524-4532.
31. Hardie D.G. AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer. Biochem. Soc. Trans. 2011, 39:1-13.
32. Steer H.J., Lake R.A., Nowak A.K., Robinson B.W. Harnessing the immune response to treat cancer. Oncogene 2010, 29:6301-6313.