Malaria Prevention in Travelers

Infectious Disease Clinics of North America

Volumn 26, Issue 3, 2012, Pages 637-654

  Genton, Blaise ^a,b   D'Acremont, Valérie ^a,c  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

Chemoprophylaxis; Malaria; Prevention; Stand by emergency treatment; Travel

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; ATOVAQUONE PLUS PROGUANIL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHLOROQUINE; CHLOROQUINE PLUS PROGUANIL; DIHYDROARTEMISININ PLUS PIPERAQUINE; DOXYCYCLINE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; HYDROXYCHLOROQUINE; INSECT REPELLENT; MEFLOQUINE; PHENOBARBITAL; PHENYTOIN; PRIMAQUINE; SUPRACYCLINE; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ANTIMALARIAL DRUG RESISTANCE; ANXIETY; BED NET; CHRONIC LIVER DISEASE; DEPRESSION; DIAGNOSTIC TEST; DIARRHEA; DISEASE TRANSMISSION; DIZZINESS; DRUG BLOOD LEVEL; DRUG CHOICE; DRUG CONTRAINDICATION; DRUG EFFICACY; DRUG ERUPTION; DRUG FATALITY; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG METABOLISM; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EARLY DIAGNOSIS; EMERGENCY TREATMENT; EMPORIATRICS; ENDEMIC DISEASE; ENVIRONMENTAL EXPOSURE; EPILEPSY; ESOPHAGUS ULCER; FEVER; GASTROINTESTINAL SYMPTOM; HEALTH EDUCATION; HEALTH STATUS; HEART DISEASE; HEMOLYTIC ANEMIA; HEPATITIS; HIGH RISK POPULATION; HOST PARASITE INTERACTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RISK; INSECT BITE; INSOMNIA; KIDNEY DISEASE; LOADING DRUG DOSE; MALARIA; MALARIA CONTROL; MALARIA FALCIPARUM; MENTAL DISEASE; METHEMOGLOBINEMIA; MOOD CHANGE; MOUTH ULCER; NAUSEA; ORGAN TRANSPLANTATION; PATIENT COMPLIANCE; PATIENT COUNSELING; PHOTOSENSITIVITY; PLASMODIUM VIVAX MALARIA; PREGNANT WOMAN; PROTECTIVE CLOTHING; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETINOPATHY; REVIEW; RISK BENEFIT ANALYSIS; SIDE EFFECT; SKIN TOXICITY; SUICIDE; SUNBURN; TRAVEL; TREATMENT DURATION; UNPLEASANT DREAM; UNSPECIFIED SIDE EFFECT; VAGINA CANDIDIASIS; VIVID DREAM; VOMITING;

ANTIMALARIALS; CHILD, PRESCHOOL; FEMALE; HUMANS; INSECT BITES AND STINGS; MALARIA; MALE; PATIENT EDUCATION AS TOPIC; PREGNANCY; RISK ASSESSMENT; TRAVEL; TRAVEL MEDICINE;

EID: 84865979220     PISSN: 08915520     EISSN: 15579824     Source Type: Journal    
DOI: 10.1016/j.idc.2012.05.003     Document Type: Review

References (29)

1. Public Health Agency of Canada Canadian recommendations for the prevention and treatment of malaria among international travellers. CCDR 2008, 34S3:1-45. Available at:, Accessed December 21, 2011. http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/09vol35/35s1/index-eng.php.
2. Steffen R., Heusser R., Mächler R., et al. Malaria chemoprophylaxis among European tourists in tropical Africa: use, adverse reactions, and efficacy. Bull World Health Organ 1990, 68(3):313-322.
3. Phillips-Howard P.A., Radalowicz A., Mitchell J., et al. Risk of malaria in British residents returning from malarious areas. BMJ 1990, 300(6723):499-503.
4. Askling H.H., Nilsson J., Tegnell A., et al. Malaria risk in travelers. Emerg Infect Dis 2005, 11(3):436-441.
5. Leder K., Black J., O'Brien D., et al. Malaria in travelers: a review of the GeoSentinel surveillance network. Clin Infect Dis 2004, 39(8):1104-1112.
6. WHO. World malaria report 2010. Available at: Accessed January 10, 2012. http://www.who.int/malaria/world_malaria_report_2010/en/index.html.
7. D'Acremont V., Lengeler C., Genton B. Reduction in the proportion of fevers associated with Plasmodium falciparum parasitaemia in Africa: a systematic review. Malar J 2010, 9:240.
8. Behrens R.H., Bisoffi Z., Björkman A., et al. Malaria prophylaxis policy for travellers from Europe to the Indian subcontinent. Malar J 2006, 5:7.
9. Behrens R.H., Carroll B., Beran J., et al. The low and declining risk of malaria in travellers to Latin America: is there still an indication for chemoprophylaxis?. Malar J 2007, 6:114.
10. Seringe E., Thellier M., Fontanet A., et al. Severe imported Plasmodium falciparum malaria, France, 1996-2003. Emerg Infect Dis 2011, 17(5):807-813.
11. Lobel H.O., Baker M.A., Gras F.A., et al. Use of malaria prevention measures by North American and European travelers to East Africa. J Travel Med 2001, 8(4):167-172.
12. Landry P., Iorillo D., Darioli R., et al. Do travelers really take their mefloquine malaria chemoprophylaxis? Estimation of adherence by an electronic pillbox. J Travel Med 2006, 13(1):8-14.
13. Chen L.H., Wilson M.E., Schlagenhauf P. Controversies and misconceptions in malaria chemoprophylaxis for travelers. JAMA 2007, 297(20):2251-2263.
14. Schlagenhauf P., Tschopp A., Johnson R., et al. Tolerability of malaria chemoprophylaxis in non-immune travellers to sub-Saharan Africa: multicentre, randomised, double blind, four arm study. BMJ 2003, 327(7423):1078.
15. Schlagenhauf P., Adamcova M., Regep L., et al. The position of mefloquine as a 21st century malaria chemoprophylaxis. Malar J 2010, 9:357.
16. Schlagenhauf P. Cochrane Review highlights the need for more targeted research on the tolerability of malaria chemoprophylaxis in travellers. Evid Based Med 2010, 15(1):25-26.
17. Kuhn S., Gill M.J., Kain K.C. Emergence of atovaquone-proguanil resistance during treatment of Plasmodium falciparum malaria acquired by a non-immune north American traveller to West Africa. Am J Trop Med Hyg 2005, 72(4):407-409.
18. Osei-Akoto A., Orton L., Owusu-Ofori S.P.O. Atovaquone-proguanil for treating uncomplicated malaria. Cochrane Database Syst Rev 2005, (4). CD004529.
19. Taylor W.R.J., White N.J. Antimalarial drug toxicity: a review. Drug Saf 2004, 27(1):25-61.
20. Tan K.R., Magill A.J., Parise M.E., et al. Doxycycline for malaria chemoprophylaxis and treatment: report from the CDC expert meeting on malaria chemoprophylaxis. Am J Trop Med Hyg 2011, 84(4):517-531.
21. Griffith K.S., Lewis L.S., Mali S., et al. Treatment of malaria in the United States: a systematic review. JAMA 2007, 297(20):2264-2277.
22. Baird J.K., Fryauff D.J., Hoffman S.L. Primaquine for prevention of malaria in travelers. Clin Infect Dis 2003, 37(12):1659-1667.
23. WHO. International travel and health. Available at: Accessed December 22, 2011. http://www.who.int/ith/chapters/en/index.html.
24. Jacquerioz F.A., Croft A.M. Drugs for preventing malaria in travellers. Cochrane Database Syst Rev 2009, (4). CD006491.
25. Senn N., D'Acremont V., Landry P., et al. Malaria chemoprophylaxis: what do the travelers choose, and how does pretravel consultation influence their final decision. Am J Trop Med Hyg 2007, 77(6):1010-1014.
26. Hatz C., Soto J., Nothdurft H.D., et al. Treatment of acute uncomplicated falciparum malaria with artemether-lumefantrine in nonimmune populations: a safety, efficacy, and pharmacokinetic study. Am J Trop Med Hyg 2008, 78(2):241-247.
27. Nothdurft H.D., Jelinek T., Pechel S.M., et al. Stand-by treatment of suspected malaria in travellers. Trop Med Parasitol 1995, 46(3):161-163.
28. Jelinek T., Amsler L., Grobusch M.P., et al. Self-use of rapid tests for malaria diagnosis by tourists. Lancet 1999, 354(9190):1609.
29. Chen L.H., Wilson M.E., Schlagenhauf P. Prevention of malaria in long-term travelers. JAMA 2006, 296(18):2234-2244.