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Volumn 7, Issue 3, 2012, Pages 235-240

Targeting chemokine receptor CCR4 in adult T-cell leukemia-lymphoma and other T-cell lymphomas

Author keywords

Adult T cell leukemia lymphoma; ATL; CCR4; Chemokine receptor; KW 0761; Mogamulizumab; Monoclonal antibody; Peripheral T cell lymphoma; PTCL

Indexed keywords

ALEMTUZUMAB; BORTEZOMIB; BRENTUXIMAB VEDOTIN; CARBOPLATIN; CHEMOKINE RECEPTOR CCR4; CYCLOPHOSPHAMIDE; DENILEUKIN DIFTITOX; DOXORUBICIN; ETOPOSIDE; FLUDARABINE; FORODESINE; GEMCITABINE; LENALIDOMIDE; MOGAMULIZUMAB; NELARABINE; PANOBINOSTAT; PRALATREXATE; PREDNISONE; RANIMUSTINE; ROMIDEPSIN; SIPLIZUMAB; VINCRISTINE; VINDESINE; VORINOSTAT;

EID: 84865976421     PISSN: 15588211     EISSN: 1558822X     Source Type: Journal    
DOI: 10.1007/s11899-012-0124-3     Document Type: Article
Times cited : (44)

References (46)
  • 1
    • 8544264540 scopus 로고    scopus 로고
    • Peripheral t-cell lymphomas. Clinico-pathologic study of 168 cases diagnosed according to the R.E.A.L. Classification
    • Ascani S, Zinzani PL, Gherlinzoni F, et al. Peripheral T-cell lymphomas. Clinico-pathologic study of 168 cases diagnosed according to the R.E.A.L. Classification. Ann Onco. 1997;8:583-92.
    • (1997) Ann Onco. , vol.8 , pp. 583-592
    • Ascani, S.1    Zinzani, P.L.2    Gherlinzoni, F.3
  • 2
    • 0031853058 scopus 로고    scopus 로고
    • Epidemiology of the non-hodgkin's lymphomas: Distributions of the major subtypes differ by geographic locations. Non-hodgkin's lymphoma classification project
    • Anderson JR, Armitage JO, Weisenburger DD. Epidemiology of the non-Hodgkin's lymphomas: distributions of the major subtypes differ by geographic locations. Non-Hodgkin's Lymphoma Classification Project. Ann Oncol. 1998;9:717-20.
    • (1998) Ann Oncol. , vol.9 , pp. 717-720
    • Anderson, J.R.1    Armitage, J.O.2    Weisenburger, D.D.3
  • 3
    • 0027162505 scopus 로고
    • Phenotypic analysis of peripheral t cell lymphoma among the japanese
    • Nakamura S, Koshikawa T, Koike K, et al. Phenotypic analysis of peripheral T cell lymphoma among the Japanese. Acta Pathol Jpn. 1993;43:396-412.
    • (1993) Acta Pathol Jpn. , vol.43 , pp. 396-412
    • Nakamura, S.1    Koshikawa, T.2    Koike, K.3
  • 4
    • 38849130620 scopus 로고    scopus 로고
    • Distribution ofmalignant lymphoma in japan: Analysis of 2260 cases 2001-2006
    • Aoki R,Karube K, SugitaY, et al.Distribution ofmalignant lymphoma in Japan: analysis of 2260 cases, 2001-2006. Pathol Int. 2008;58:174-82.
    • (2008) Pathol Int , vol.58 , pp. 174-182
    • Aoki, R.1    Karube, K.2    Sugita, Y.3
  • 6
    • 79955750585 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network (NCCN). NCCN Clinical Practice Guidelines In Oncology. V.1.2010. Fort Washington PA: NCCN
    • National Comprehensive Cancer Network (NCCN). Non-Hodgkin's lymphomas. NCCN clinical practice guidelines in oncology. v.1.2010. Fort Washington, PA: NCCN; 2010.
    • (2010) Non-Hodgkin's Lymphomas
  • 7
    • 0037165261 scopus 로고    scopus 로고
    • Chop chemotherapy plus rituximab compared with chop alone in elderly patients with diffuse large b-cell lymphoma
    • Coiffier B, Lepage E, Brière J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large B-cell lymphoma. N Engl J Med. 2002;346:235-42.
    • (2002) N Engl J Med. , vol.346 , pp. 235-242
    • Coiffier, B.1    Lepage, E.2    Brière, J.3
  • 8
    • 38349119981 scopus 로고    scopus 로고
    • Bendamustine in patients with rituximab-refractory indolent and transformed non-hodgkin's lymphoma: Results from a phase ii multicenter, single-agent study
    • Friedberg JW, Cohen P, Chen L, et al. Bendamustine in patients with rituximab-refractory indolent and transformed non-Hodgkin's lymphoma: results from a phase II multicenter, single-agent study. J Clin Oncol. 2008;26:204-10.
    • (2008) J Clin Oncol. , vol.26 , pp. 204-210
    • Friedberg, J.W.1    Cohen, P.2    Chen, L.3
  • 9
    • 0028211673 scopus 로고
    • Clinical features and treatment outcome for children with cd30+ large-cell non-hodgkin's lymphoma
    • Sandlund JT, Pui CH, Santana VM, et al. Clinical features and treatment outcome for children with CD30+ large-cell non-Hodgkin's lymphoma. J Clin Oncol. 1994;12:895-8.
    • (1994) J Clin Oncol. , vol.12 , pp. 895-898
    • Sandlund, J.T.1    Pui, C.H.2    Santana, V.M.3
  • 10
    • 51649091675 scopus 로고    scopus 로고
    • International t-cell lymphoma project. International peripheral t-cell and natural killer/t-cell lymphoma study: Pathology findings and clinical outcomes
    • Vose J, Armitage J,Weisenburger D. International T-Cell Lymphoma Project. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol. 2008;26:4124-30.
    • (2008) J Clin Oncol. , vol.26 , pp. 4124-4130
    • Vose, J.1    Armitage, J.2    Weisenburger, D.3
  • 11
    • 79959503595 scopus 로고    scopus 로고
    • Peripheral t-cell lymphoma
    • Foss FM, Zinzani PL, Vose JM, et al. Peripheral T-cell lymphoma. Blood. 2011;117:6756-67.
    • (2011) Blood. , vol.117 , pp. 6756-6767
    • Foss, F.M.1    Zinzani, P.L.2    Vose, J.M.3
  • 12
    • 79952093148 scopus 로고    scopus 로고
    • Ethnoepidemiology of htlv-1 related diseases: Ethnic determinants of htlv-1 susceptibility and its worldwide dispersal
    • Sonoda S, Li HC, Tajima K. Ethnoepidemiology of HTLV-1 related diseases: ethnic determinants of HTLV-1 susceptibility and its worldwide dispersal. Cancer Sci. 2011;102:295-301.
    • (2011) Cancer Sci. , vol.102 , pp. 295-301
    • Sonoda, S.1    Li, H.C.2    Tajima, K.3
  • 13
    • 77956535619 scopus 로고    scopus 로고
    • Human t-cell leukemia virus type i (htlv-1) proviral load and disease progression in asymptomatic htlv-1 carriers: A nationwide prospective study in japan
    • Iwanaga M, Watanabe T, Utsunomiya A, et al. Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan. Blood. 2010;116:1211-9.
    • (2010) Blood. , vol.116 , pp. 1211-1219
    • Iwanaga, M.1    Watanabe, T.2    Utsunomiya, A.3
  • 14
    • 0042175289 scopus 로고    scopus 로고
    • Human t lymphotropic virus type-i and adult t-cell leukemia in japan
    • Yamaguchi K, Watanabe T. Human T lymphotropic virus type-I and adult T-cell leukemia in Japan. Int J Hematol. 2002;76 Suppl 2:240-5.
    • (2002) Int J Hematol. , vol.76 , Issue.SUPPL. 2 , pp. 240-245
    • Yamaguchi, K.1    Watanabe, T.2
  • 15
    • 0026095532 scopus 로고
    • Diagnostic criteria and classification of clinical subtypes of adult t-cell leukaemia-lymphoma: A report from the lymphoma study group (1984-87
    • Shimoyama M. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma: A report from the Lymphoma Study Group (1984-87). Br J Haematol. 1991;79:428-37.
    • (1991) Br J Haematol. , vol.79 , pp. 428-437
    • Shimoyama, M.1
  • 16
    • 58549103931 scopus 로고    scopus 로고
    • Definition, prognostic factors, treatment, and response criteria of adult t-cell leukemia-lymphoma: A proposal from an international consensus meeting
    • Tsukasaki K, Hermine O, Bazarbachi A, et al. Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting. J Clin Oncol. 2009;27:453-9.
    • (2009) J Clin Oncol. , vol.27 , pp. 453-49
    • Tsukasaki, K.1    Hermine, O.2    Bazarbachi, A.3
  • 17
    • 77950616240 scopus 로고    scopus 로고
    • Clinical trials for human t-cell lymphotropic virus type i-associated peripheral t-cell lymphoma in japan
    • Tobinai K. Clinical trials for human T-cell lymphotropic virus type I-associated peripheral T-cell lymphoma in Japan. Semin Hematol. 2010;47 Suppl 1:S5-7.
    • (2010) Semin Hematol , vol.47 , Issue.SUPPL. 1
    • Tobinai, K.1
  • 18
    • 0035004336 scopus 로고    scopus 로고
    • A new g-csfsupported combination chemotherapy, lsg15, for adult t-cell leukaemia-lymphoma: Japan clinical oncology group study 9303
    • Yamada Y, Tomonaga M, Fukuda H, et al. A new G-CSFsupported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303. Br J Haematol. 2001;113:375-82.
    • (2001) Br J Haematol. , vol.113 , pp. 375-382
    • Yamada, Y.1    Tomonaga, M.2    Fukuda, H.3
  • 19
    • 36849051298 scopus 로고    scopus 로고
    • Vcap-amp-vecp compared with biweekly chop for adult t-cell leukemialymphoma: Japan clinical oncology group study jcog9801
    • Tsukasaki K, Utsunomiya A, Fukuda H, et al. VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemialymphoma: Japan Clinical Oncology Group Study JCOG9801. J Clin Oncol. 2007;25:5458-64.
    • (2007) J Clin Oncol. , vol.25 , pp. 5458-5464
    • Tsukasaki, K.1    Utsunomiya, A.2    Fukuda, H.3
  • 20
    • 77957962485 scopus 로고    scopus 로고
    • Meta-analysis on the use of zidovudine and interferon-alfa in adult t-cell leukemia/lymphoma showing improved survival in the leukemic subtypes
    • Bazarbachi A, Plumelle Y, Carlos Ramos J, et al. Meta-analysis on the use of zidovudine and interferon-alfa in adult T-cell leukemia/lymphoma showing improved survival in the leukemic subtypes. J Clin Oncol. 2010;28:4177-83.
    • (2010) J Clin Oncol. , vol.28 , pp. 4177-83
    • Bazarbachi, A.1    Plumelle, Y.2    Carlos Ramos, J.3
  • 21
    • 34249734842 scopus 로고    scopus 로고
    • Daclizumab (anti-tac, zenapax) in the treatment of leukemia/lymphoma
    • Waldmann TA. Daclizumab (anti-Tac, Zenapax) in the treatment of leukemia/lymphoma. Oncogene. 2007;26:3699-703.
    • (2007) Oncogene. , vol.26 , pp. 3699-703
    • Waldmann, T.A.1
  • 22
    • 0038240426 scopus 로고    scopus 로고
    • Effective therapy for a murine model of adult t-cell leukemia with the humanized anti-cd2 monoclonal antibody medi-507
    • Zhang Z, Zhang M, Ravetch JV, et al. Effective therapy for a murine model of adult T-cell leukemia with the humanized anti-CD2 monoclonal antibody, MEDI-507. Blood. 2003;102:284-8.
    • (2003) Blood. , vol.102 , pp. 284-8
    • Zhang, Z.1    Zhang, M.2    Ravetch, J.V.3
  • 23
    • 0141885088 scopus 로고    scopus 로고
    • Effective therapy for a murine model of adult t-cell leukemia with the humanized anti-cd52 monoclonal antibody campath-1h
    • Zhang Z, Zhang M, Goldman CK, et al. Effective therapy for a murine model of adult T-cell leukemia with the humanized anti-CD52 monoclonal antibody, Campath-1H. Cancer Res. 2003;63:6453-7.
    • (2003) Cancer Res. , vol.63 , pp. 6453-7
    • Zhang, Z.1    Zhang, M.2    Goldman, C.K.3
  • 24
    • 27844536515 scopus 로고    scopus 로고
    • Complete response in a patient with adult t-cell leukemia (atl) treated with combination of alemtuzumab and pentostatin
    • Ravandi F, Faderl S. Complete response in a patient with adult T-cell leukemia (ATL) treated with combination of alemtuzumab and pentostatin. Leuk Res. 2006;30:103-5.
    • (2006) Leuk Res. , vol.30 , pp. 103-5
    • Ravandi, F.1    Faderl, S.2
  • 25
    • 38349170646 scopus 로고    scopus 로고
    • Recent advances in adult t-cell leukemia therapy: Focus on a new anti-transferrin receptor monoclonal antibody
    • Callens C, Moura IC, Lepelletier Y, et al. Recent advances in adult T-cell leukemia therapy: focus on a new anti-transferrin receptor monoclonal antibody. Leukemia. 2008;22:42-8.
    • (2008) Leukemia. , vol.22 , pp. 42-8
    • Callens, C.1    Moura, I.C.2    Lepelletier, Y.3
  • 26
    • 33645010937 scopus 로고    scopus 로고
    • Role of single-agent purine analogues in therapy of peripheral t-cell lymphomas
    • Dearden CE. Role of single-agent purine analogues in therapy of peripheral T-cell lymphomas. Semin Hematol. 2006;43:S22-6.
    • (2006) Semin Hematol. , vol.43
    • Dearden, C.E.1
  • 27
    • 74249117327 scopus 로고    scopus 로고
    • Current management of adult t-cell leukemia/lymphoma
    • Tobinai K. Current management of adult T-cell leukemia/lymphoma. Oncology (Williston Park). 2009;23:1250-6.
    • (2009) Oncology (Williston Park). , vol.23 , pp. 1250-1256
    • Tobinai, K.1
  • 28
    • 79952749741 scopus 로고    scopus 로고
    • Pralatrexate in patients with relapsed or refractory peripheral t-cell lymphoma: Results from the pivotal propel study
    • O'Connor OA, Pro B, Pinter-Brown L, et al. Pralatrexate in patients with relapsed or refractory peripheral T-cell lymphoma: results from the pivotal PROPEL study. J Clin Oncol. 2011;29:1182-9.
    • (2011) J Clin Oncol. , vol.29 , pp. 1182-1189
    • O'Connor, O.A.1    Pro, B.2    Pinter-Brown, L.3
  • 29
    • 0032533795 scopus 로고    scopus 로고
    • Selective up-regulation of chemokine receptors ccr4 and ccr8 upon activation of polarized human type 2 th cells
    • D'Ambrosio D, Iellem A, Bonecchi R, et al. Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J Immunol. 1998;161:5111-5.
    • (1998) J Immunol. , vol.161 , pp. 5111-5115
    • D'Ambrosio, D.1    Iellem, A.2    Bonecchi, R.3
  • 30
    • 0035903307 scopus 로고    scopus 로고
    • Unique chemotactic response profile and specific expression of chemokine receptors ccr4 and ccr8 by cd4(+)cd25(+) regulatory t cells
    • Iellem A, Mariani M, Lang R, et al. Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J Exp Med. 2001;194:847-53.
    • (2001) J Exp Med. , vol.194 , pp. 847-853
    • Iellem, A.1    Mariani, M.2    Lang, R.3
  • 31
    • 1642554783 scopus 로고    scopus 로고
    • Dominance of ccl22 over ccl17 in induction of chemokine receptor ccr4 desensitization and internalization on human th2 cells
    • Mariani M, Lang R, Binda E, et al. Dominance of CCL22 over CCL17 in induction of chemokine receptor CCR4 desensitization and internalization on human Th2 cells. Eur J Immunol. 2004;34:231-40.
    • (2004) Eur J Immunol. , vol.34 , pp. 231-240
    • Mariani, M.1    Lang, R.2    Binda, E.3
  • 32
    • 12444272236 scopus 로고    scopus 로고
    • Clinical significance of ccr4 expression in adult t-cell leukemia/lymphoma: Its close association with skin involvement and unfavorable outcome
    • Ishida T, Utsunomiya A, Iida S, et al. Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome. Clin Cancer Res. 2003;9:3625-34.
    • (2003) Clin Cancer Res. , vol.9 , pp. 3625-2634
    • Ishida, T.1    Utsunomiya, A.2    Iida, S.3
  • 33
    • 44349111367 scopus 로고    scopus 로고
    • Aberrant expression of fra-2 promotes ccr4 expression and cell proliferation in adult t-cell leukemia
    • Nakayama T, Hieshima K, Arao T, et al. Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia. Oncogene. 2008;27:3221-32.
    • (2008) Oncogene. , vol.27 , pp. 3221-332
    • Nakayama, T.1    Hieshima, K.2    Arao, T.3
  • 34
    • 4143049161 scopus 로고    scopus 로고
    • Cxc chemokine receptor 3 and cc chemokine receptor 4 expression in t-cell and nk-cell lymphomas with special reference to clinicopathological significance for peripheral t-cell lymphoma, unspecified
    • Ishida T, Inagaki H, Utsunomiya A, et al. CXC chemokine receptor 3 and CC chemokine receptor 4 expression in T-cell and NK-cell lymphomas with special reference to clinicopathological significance for peripheral T-cell lymphoma, unspecified. Clin Cancer Res. 2004;10:5494-500.
    • (2004) Clin Cancer Res. , vol.10 , pp. 5494-5500
    • Ishida, T.1    Inagaki, H.2    Utsunomiya, A.3
  • 35
    • 0034661509 scopus 로고    scopus 로고
    • Expression pattern of t-cellassociated chemokine receptors and their chemokines correlates with specific subtypes of t-cell non-hodgkin lymphoma
    • Jones D, O'Hara C, Kraus MD, et al. Expression pattern of T-cellassociated chemokine receptors and their chemokines correlates with specific subtypes of T-cell non-Hodgkin lymphoma. Blood. 2000;96:685-90.
    • (2000) Blood. , vol.96 , pp. 685-690
    • Jones, D.1    O'Hara, C.2    Kraus, M.D.3
  • 36
    • 58949084192 scopus 로고    scopus 로고
    • Array comparative genomic hybridization analysis of ptcl-u reveals a distinct subgroup with genetic alterations similar to lymphoma-type adult tcell leukemia/lymphoma
    • Nakagawa M, Nakagawa-Oshiro A, Karnan S, et al. Array comparative genomic hybridization analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type adult Tcell leukemia/lymphoma. Clin Cancer Res. 2009;15:30-8.
    • (2009) Clin Cancer Res. , vol.15 , pp. 30-38
    • Nakagawa, M.1    Nakagawa-Oshiro, A.2    Karnan, S.3
  • 37
    • 0032908743 scopus 로고    scopus 로고
    • Selective recruitment of ccr4-bearing th2 cells toward antigen-presenting cells by the cc chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine
    • Imai T, Nagira M, Takagi S, et al. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int Immunol. 1999;11:81-8.
    • (1999) Int Immunol. , vol.11 , pp. 81-88
    • Imai, T.1    Nagira, M.2    Takagi, S.3
  • 38
    • 12144289636 scopus 로고    scopus 로고
    • Defucosylated chimeric anti-cc chemokine receptor 4 igg1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to t-cell leukemia and lymphoma
    • Niwa R, Shoji-Hosaka E, Sakurada M, et al. Defucosylated chimeric anti-CC chemokine receptor 4 IgG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T-cell leukemia and lymphoma. Cancer Res. 2004;64:2127-33.
    • (2004) Cancer Res. , vol.64 , pp. 2127-2133
    • Niwa, R.1    Shoji-Hosaka, E.2    Sakurada, M.3
  • 39
    • 77649123143 scopus 로고    scopus 로고
    • Defucosylated humanized anti-ccr4 monoclonal antibody kw-0761 as a novel immunotherapeutic agent for adult t-cell leukemia/lymphoma
    • Ishii T, Ishida T, Utsunomiya A, et al. Defucosylated humanized anti-CCR4 monoclonal antibody KW-0761 as a novel immunotherapeutic agent for adult T-cell leukemia/lymphoma. Clin Cancer Res. 2010;16:1520-31.
    • (2010) Clin Cancer Res. , vol.16 , pp. 1520-1531
    • Ishii, T.1    Ishida, T.2    Utsunomiya, A.3
  • 40
    • 0037474276 scopus 로고    scopus 로고
    • The absence of fucose but not the presence of galactose or bisecting n-acetylglucosamine of human igg1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity
    • Shinkawa T, Nakamura K, Yamane N, et al. The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity. J Biol Chem. 2003;278:3466-73.
    • (2003) J Biol Chem. , vol.278 , pp. 3466-2473
    • Shinkawa, T.1    Nakamura, K.2    Yamane, N.3
  • 41
    • 38949129092 scopus 로고    scopus 로고
    • Augmentation of antitumour activity of defucosylated chimeric anti-ccr4 monoclonal antibody in scid mouse model of adult t-cell leukaemia/lymphoma using g-csf
    • Yano H, Ishida T, Imada K, et al. Augmentation of antitumour activity of defucosylated chimeric anti-CCR4 monoclonal antibody in SCID mouse model of adult T-cell leukaemia/lymphoma using G-CSF. Br J Haematol. 2008;140:586-9.
    • (2008) Br J Haematol. , vol.140 , pp. 586-589
    • Yano, H.1    Ishida, T.2    Imada, K.3
  • 42
    • 70449711386 scopus 로고    scopus 로고
    • Defucosylated anti-ccr4 monoclonal antibody exerts potent adcc against primary atll cells mediated by autologous human immune cells in nod/shi-scid, il-2r gamma(null) mice in vivo
    • Ito A, Ishida T, Utsunomiya A, et al. Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo. J Immunol. 2009;183:4782-91.
    • (2009) J Immunol. , vol.183 , pp. 4782-4791
    • Ito, A.1    Ishida, T.2    Utsunomiya, A.3
  • 43
    • 77951916883 scopus 로고    scopus 로고
    • Phase i study of kw-0761, a defucosylated humanized anti-ccr4 antibody, in relapsed patients with adult t-cell leukemia-lymphoma and peripheral t-cell lymphoma
    • This manuscript describes the results of a phase I study of mogamulizumab (KW-0761) in ATL and PTCL, showing encouraging therapeutic efficacy with acceptable toxicity profiles
    • Yamamoto K, Utsunomiya A, Tobinai K, et al. Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. J Clin Oncol. 2010;28:1591-8. This manuscript describes the results of a phase I study of mogamulizumab (KW-0761) in ATL and PTCL, showing encouraging therapeutic efficacy with acceptable toxicity profiles.
    • (2010) J Clin Oncol. , vol.28 , pp. 1591-1598
    • Yamamoto, K.1    Utsunomiya, A.2    Tobinai, K.3
  • 45
    • 84863393084 scopus 로고    scopus 로고
    • Defucosylated anti-ccr4monoclonal antibody (kw-0761) for relapsed adult t-cell leukemia-lymphoma: A multicenter phase ii study
    • This manuscript describes the results of a phase II study of mogamulizumab/KW-0761 in relapsed patients with ATL, yielding a best overall response rate of 50% and median progression-free survival of 5.2 months
    • Ishida T, Joh T,UikeN, et al.Defucosylated anti-CCR4monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study. J Clin Oncol. 2012;30:837-42. This manuscript describes the results of a phase II study of mogamulizumab/KW-0761 in relapsed patients with ATL, yielding a best overall response rate of 50% and median progression-free survival of 5.2 months.
    • (2012) J Clin Oncol. , vol.30 , pp. 837-842
    • Ishida, T.1    Joh, T.2    Uike, N.3
  • 46
    • 84870810294 scopus 로고    scopus 로고
    • Results of a phase 12 study for kw-0761 a monoclonal antibody directed against cc chemokine receptor type 4 (ccr4) in ctcl patients
    • [abstract 962]. Presented at the. Orlando, USA; December 4-7
    • Duvic M, Pinter-Brown L, Foss FM, et al.: Results of a phase 1/2 study for KW-0761, a monoclonal antibody directed against CC chemokine receptor type 4 (CCR4), in CTCL patients. [abstract 962]. Presented at the 52nd Annual Meeting of the American Society of Hematology. Orlando, USA; December 4-7, 2010.
    • (2010) 52nd Annual Meeting of the American Society of Hematology
    • Duvic, M.1    Pinter-Brown, L.2    Foss, F.M.3


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