Thyroid hormone action on skin

Current Opinion in Endocrinology, Diabetes and Obesity

Volumn 19, Issue 5, 2012, Pages 388-393

  Safer, Joshua D ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cutaneous; epidermis; skin; thyroid hormone action

Indexed keywords

IMMUNOGLOBULIN E ANTIBODY; LIOTHYRONINE; THYROID HORMONE; THYROID HORMONE RECEPTOR; THYROID PEROXIDASE ANTIBODY; THYROXINE; TIRATRICOL;

ALOPECIA AREATA; ANGIONEUROTIC EDEMA; AUTOIMMUNITY; BULLOUS PEMPHIGOID; CELL PROLIFERATION; DERMATITIS HERPETIFORMIS; DERMIS; EPIDERMIS; GRAVES DISEASE; HAIR; HORMONE ACTION; HORMONE BINDING; HUMAN; HYPERPIGMENTATION; HYPOTHYROIDISM; IN VITRO STUDY; IN VIVO STUDY; LICHEN SCLEROSUS ET ATROPHICUS; LUPUS ERYTHEMATOSUS; MYXEDEMA; NAIL; NONHUMAN; PEMPHIGUS; PERNICIOUS ANEMIA; PUSTULOSIS PALMOPLANTARIS; REVIEW; SCLERODERMA; SKIN CELL; SKIN FUNCTION; SKIN MANIFESTATION; SKIN STIMULATION; TENSILE STRENGTH; THYROID DISEASE; THYROTOXICOSIS; URTICARIA; VITILIGO; WOUND HEALING;

CELL PROLIFERATION; FEMALE; HAIR DISEASES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MYXEDEMA; NAIL DISEASES; RECEPTORS, THYROID HORMONE; SKIN DISEASES, ECZEMATOUS; THYROID HORMONES; THYROTOXICOSIS;

EID: 84865968596     PISSN: 1752296X     EISSN: 17522978     Source Type: Journal    
DOI: 10.1097/MED.0b013e328357b45e     Document Type: Review

References (84)

1. Ord WM. On myxoedema, term proposed to be applied to an essential condition in the 'cretinoid' affection occasionally observed in middle-aged women. Med Chir Trans Lond 1878; 61:57-78.
2. Horsley V. The thyroid gland: its relation to the pathology of myxoedema and cretinism, to the question of surgical treatment of goitre, and to the general nutrition of the body. Br Med J 1885; 1:111-115.
3. Fisher C, Blumenberg M, Tomic-Canic M. Retinoid receptors and keratinocytes. Crit Rev Oral Biol Med 1995; 6:284-301.
4. Holick MF. McCollum award lecture, 1994: vitamin D - new horizons for the 21st century. Am J Nutr 1994; 60:619-630.
5. Abulkadir J, Besrat A, Abraham G, et al. Thyrotoxicosis in Ethiopian patients -a prospective study. Trans R Soc Trop Med Hyg 1982; 76:500-502.
6. Warthin TA, Boshell BR. Pretibial myxedema treated with local injection of triiodothyronine. Am Med Assoc Arch Intern Med 1957; 100:319-321.
7. Gabrilove JL, Alavarez AS, Churg J. Generalized and localized (pretibial) myxedema: effect of thyroid analogues and adrenal glucocorticoids. J Clin Endocrinol 1960; 20:825-832.
8. Gimlette TMD. Pretibial myxedema. Br Med J 1960; 2:348-351.
9. Cohen BD, Benua RS, Rawson RW. Localized myxedema involving the upper extremities. Arch Intern Med 1963; 111:641-646.
10. Berman A. Peripheral effects of L-thyroxine on hair growth and coloration in cattle. J Endocrinol 1960; 20:288-292.
11. Ahsan MK, Urano Y, Kato S, et al. Immunohistochemical localization of thyroid hormone nuclear receptors in human hair follicles and in vitro effect of L-triiodothyronine on cultured cells of hair follicles and skin. J Med Investig 1998; 44:179-184.
12. Torma H, Rollman O, Vahlquist A. Detection of mRNA transcripts for retinoic acid, vitamin D3, and thyroid hormone (c-erb-A) nuclear receptors in human skin using reverse transcription and polymerase chain reaction. Acta Derm Venereol 1993; 73:102-107.
13. Billoni N, Buan B, Gautier B, et al. Thyroid hormone receptor beta-1 is expressed in the human hair follicle. Br J Dermatol 2000; 142:645-652.
14. Torma H, Karlsson T, MichaelssonG, et al. Decreased mRNA levels of retinoic acid receptor-alpha, retinoid X receptor-alpha and thyroid hormone receptoralpha in lesional psoriatic skin. Acta Derm Venereol 2000; 80:4-9.
15. Bianco AC, Salvatore D, Gereben B, et al. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 2002; 23:38-89.
16. Bianco AC, Kim BW. Deiodinases: implications of the local control of thyroid hormone action. J Clin Invest 2006; 116:2571-2579.
17. Refetoff S, Matalon R, Bigazzi M. Metabolism of L-thyroxine (T4) and L-triiodothyronine (T3) by human fibroblasts in tissue culture: evidence for cellular binding proteins and conversion of T4 to T3. Endocrinology 1972; 91:934-947.
18. Huang TS, Chopra IJ, Beredo A, et al. Skin is an active site for the inner ring monodeiodination of thyroxine to 3,30,50-triiodothyronine. Endocrinology 1985; 117:2106-2113.
19. Kaplan MM, Pan C, Gordon PR, et al. Human epidermal keratinocytes in culture convert thyroxine to 3,5,30-triiodothyronine by type II iodothyronine deiodination: a novel endocrine function of skin. J Clin Endocrinol Metab 1988; 66:815-822.
20. Villar D, Nichols F, Arthur JR, et al. Type II and type III monodeiodinase activities in the skin of untreated and propylthiouracil-treated cashmere goats. Res Vet Sci 2000; 68:119-123.
21. Huang MP, Rodgers KA, O'Mara R, et al. The thyroid hormone degrading type 3 deiodinase is the primary deiodinase active in murine epidermis. Thyroid 2011; 21:1263-1268.
22. Schroder-van der Elst JP, van der Heide D, de Escobar GM, Obregon MJ. Iodothyronine deiodinase activities in fetal rat tissues at several levels of iodine deficiency: a role for the skin in 3,5,30-triiodothyronine economy? Endocrinology 1998; 139:2229-2234.
23. Santini F, Vitti P, Chiovato L, et al. Role for inner ring deiodination preventing transcutaneous passage of thyroxine. J Clin Endocrinol Metab 2003; 88: 2825-2830.
24. Dumitrescu AM, Liao X-H, Abdullah MSY, et al. Mutations in SECISBP2 result in abnormal thyroid hormone metabolism. Nat Genet 2005; 37:1247-1252.
25. Tomic M, Jiang CK, Epstein HS, et al. Nuclear receptors for retinoic acid and thyroid hormone regulate transcription of keratin genes. Cell Regul 1990; 1:965-973.
26. Ohtsuki M, Tomic-Canic M, Freedberg IM, Blumenberg M. Regulation of epidermal keratin expression by retinoic acid and thyroid hormone. J Dermatol 1992; 19:774-780.
27. Thompson CC. Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog. J Neurosci 1996; 16:7832-7840.
28. Thompson CC, Bottcher MC. The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors. Proc Natl Acad Sci USA 1997; 94:8527-8532.
29. Miyazaki T, Kanou Y, Murata Y, et al. Molecular cloning of a novel thyroid hormone responsive gene, ZAKI-4, in human skin fibroblasts. J Bio Chem 1996; 271:14567-14571.
30. Slominski A, Wortsman J, Kohn L, et al. Expression of hypothalamic-pituitarythyroid axis related genes in human skin. J Invest Dermatol 2002; 119:1449-1455.
31. Bodó E, Kany B, Gáspár E, et al. Thyroid-stimulating hormone, a novel, locally produced modulator of human epidermal functions, is regulated by thyrotropinreleasing hormone and thyroid hormones. Endocrinology 2010; 151:1633-1642.
32. Paus R. Exploring the 'thyroid-skin connection': concepts, questions, and clinical relevance. J Invest Dermatol 2010; 130:93-101.
33. Contreras-Jurado C, Garcia-Serrano L, Gomez-Ferreria M, et al. The thyroid hormone receptors as modulators of skin proliferation and inflammation. J Bio Chem 2011; 286:24079-24088.
34. Garcia-Serrano L, Gomez-Ferreria MA, Contrera-Jurado C, et al. The thyroid hormone receptors modulate the skin response to retinoids. PLoS One 2011; 6:e23825.
35. Heymann WR. Cutaneous manifestations of thyroid disease. J Am Acad Dermatol 1992; 26:885.
36. Hodak E, David M, Feuerman EJ. Palmoplantar keratoderma in association with myxedema. Acta Derm Venereol (Stockh) 1986; 66:354-357.
37. Reuter MJ. Histopathology of the skin in myxedema. Arch Dermatol Syphilol 1931; 24:55-71.
38. Isseroff RR, Chun KT, Rosenberg RM. Triiodothyronine alters the cornification of cultured human keratinocytes. Br J Dermatol 1989; 120:503-510.
39. Rosenberg RM, Isseroff RR, Ziboh VA, et al. Abnormal lipogenesis in thyroid hormone-deficient epidermis. J Invest Dermatol 1986; 86:244.
40. Hanley K, Jiang Y, Katagiri C, et al. Epidermal steroid sulfatase and cholesterol sulfotransferase are regulated during late gestation in the fetal rat. J Invest Dermatol 1997; 108:871-875.
41. Hanley K, Devaskar UP, Hicks SJ, et al. Hypothyroidism delays fetal stratum corneum development in mice. Pediatr Res 1997; 42:610.
42. Holt PJA, Marks R. The epidermal response to change in thyroid status. J Investig Dermatol 1977; 68:299-301.
43. Safer JD, Fraser LM, Ray S, Holick MF. Topical triiodothyronine stimulates epidermal proliferation, dermal thickening, and hair growth in mice and rats. Thyroid 2001; 11:717-724.
44. Safer JD, Crawford TM, Fraser LM, et al. Thyroid hormone action on skin: diverging effects of topical versus intraperitoneal administration. Thyroid 2003; 13:159-165.
45. Holt PJA. In vitro responses of the epidermis to triiodothyronine. J Invest Dermatol 1978; 71:202-204.
46. Gabrilove JL, Ludwig AW. The histogenesis of myxedema. J Clin Endocrinol Metab 1957; 17:925-932.
47. Smith TJ, Bahn RS, Gorman CA. Connective tissue, glycosaminoglycans and diseases of the thyroid. Endocr Rev 1989; 10:366-391.
48. Parving H-H, Hansen JM, Nielsen SL, et al. Mechanisms of edema formation in myxedema: increased protein extravasation and relatively slow lymphatic drainage. N Engl J Med 1979; 301:460-465.
49. Smith TJ, Murata Y, Horwitz AL, et al. Regulation of glycosaminoglycan synthesis by thyroid hormone in vitro. J Clin Invest 1982; 70:1066-1073.
50. Murata Y, Ceccarelli P, Refetoff S, et al. Thyroid hormone inhibits fibronectin synthesis by cultured human skin fibroblasts. J Clin Endocrinol Metab 1987; 64:334-339.
51. De Rycker C, Vandelem J-L, Hennen G. Effect of 3,5,30-triiodothyronine on collagen synthesis by cultured human skin fibroblasts. FEBS Lett 1984; 174:34-37.
52. Fink CW, Ferguson JL, Smiley JD. Effect of hyperthyroidism and hypothyroidism on collagen metabolism. J Lab Clin Med 1967; 69:950-959.
53. Kivirikko KI, Laitinen O, Aer J, Halme J. Metabolism of collagen in experimental hyperthyroidism and hypothyroidism in the rat. Endocrinology 1967; 80: 1051-1061.
54. Faergemann J, Sarnhult T, Hedner E, et al. Dose-response effects of triiodothyroacetic acid (Triac) and other thyroid hormone analogues on glucocorticoid-induced skin atrophy in the haired mouse. Acta Derm Venereol 2002; 82:179-183.
55. Hale PA, Ebling FJ. The effect of a single epilation on successive hair eruptions in normal and hormone-treated rats. J Exp Zool 1979; 207:49-72.
56. Mullin GE, Eastern JS. Cutaneous signs of thyroid disease. Am Fam Physician 1986; 34:93-98.
57. Perloff WH. Hirsutism: a manifestation of juvinile hypothyroidism. JAMA 1955; 157:651-652.
58. Dekio S, Imaoka C, Jidoi J. Candida folliculitis associated with hypothyroidism. Br J Dermatol 1987; 117:663-664.
59. Puchala R, Prieto I, Banskalieva V, et al. Effects of bovine somatotropin and thyroid hormone status on hormone levels, body weight gain, and mohair fiber growth of Angora goats. J Anim Sci 2001; 79:2913-2919.
60. Lindenbaum ES, Feitelberg AL, Tendler M, et al. Pilot study of a novel treatment for androgenetic alopecia using enriched cell culture medium: clinical trials. Dermatol Online J 2003; 9:4.
61. Means MA, Dobson RL. Cytological changes in the sweat gland in hypothyroidism. JAMA 1963; 186:113.
62. Squires L, Dolan TF. Abnormal sweat chloride in auto-immune hypothyroidism. Clin Pediatr 1989; 28:535-536.
63. Weiss M, Milman B, Rosen B, et al. Quantitation of thyroid hormone effect on skin perfusion by laser Doppler flowmetry. J Clin Endocrinol Metab 1993; 76:680-682.
64. Pazos-Moura CC, Moura EG, Breitenbach MMD, et al. Nailfold capillaroscopy in hypothyroidism: blood flow velocity during rest and postocclusive reactive hyperemia. Angiology 1998; 49:471-476.
65. Robertshaw D. Hyperhidrosis and the sympatho-adrenal system. Med Hypotheses 1979; 5:317-322.
66. Gitter DG, Sato K. Localized hyperhidrosis in pretibial myxedema. J Am Acad Dermatol 1990; 23:250-254.
67. Diven DG, Gwinup G, Newton RC. The thyroid. Dermatol Clin 1989; 7:547-557.
68. Ai J, Leonhardt JM, Heymann WR. Autoimmune thyroid diseases: etiology, pathogenesis, and dermatologic manifestations. J Am Acad Dermatol 2003; 48:641-659.
69. Heymann WR. Chronic idiopathic urticaria and angioedema associated with thyroid autoimmunity: review and therapeutic implications. J Am Acad Dermatol 1999; 40:229-232.
70. Altrichter S, Peter H-J, Pisarevskaja D, et al. IgE mediated autoallergy against thyroid peroxidase - a novel pathomechanism of chronic spontaneous urticaria? PLoS One 2011; 6:1-6.
71. Fatourechi V, Pajouhi M, Fransway A. Dermopathy of Graves disease (pretibial myxedema). Review of 150 cases. Medicine 1994; 73:1-7.
72. Fatourechi V, Ahmed DDF, Schwartz KM. Thyroid acropachy: report of 40 patients treated at a single institution in a 26-year period. J Clin Endocrinol Metab 2002; 87:5435-5441.
73. Safer JD, Crawford TM, Holick MF. Topical thyroid hormone accelerates wound healing in mice. Endocrinology 2005; 146:4425-4430.
74. Tarameshloo M, Norouzian M, Zarein-Dolob S, et al. A comparative study of the effects of topical application of Aloe vera, thyroid hormone and silver sulfadiazine on skin wounds in Wistar rats. Lab Anim Res 2012; 28:17-21.
75. Lindenbaum ES, Har Shai Y, Ullmann Y, et al. Stimulated healing of recalcitrant wounds by topical application of enriched cell culture medium: a clinical report. Plast Reconstr Surg 2001; 108:104-113.
76. Zamick P, Mehregan AH. Effect of L-tri-iodothyronine on marginal scars of skin grafted burns in rats. Plast Reconstr Surg 1973; 51:71-75.
77. Mehregan AH, Zamick P. The effect of triiodothyronine in healing of deep dermal burns and marginal scars of skin grafts. A histologic study. J Cutan Pathol 1974; 1:113-116.
78. Lennox J, Johnston ID. The effect of thyroid status on nitrogen balance and the rate of wound healing after injury in rats. Br J Surg 1973; 60:309.
79. Pirk FW, El Attar MA, Roth GD. Effect of analogues of steroid and thyroxine hormones on wound healing in hamsters. J Periodontal Res 1974; 9:290-297.
80. Ashton IK, Dekel S. Fracture repair in the snell dwarf mouse. J Exp Pathol 1983; 64:479-486.
81. Alexander MV, Zajtchuk JT, Henderson RL. Hypothyroidism and wound healing: occurrence after head and neck radiation and surgery. Arch Otolaryngol 1982; 108:289-291.
82. Talmi YP, Finkelstein Y, Zohar Y. Pharyngeal fistulas in postoperative hypothyroid patients. Ann Otol Rhinol Laryngol 1989; 98:267-268.
83. Cannon CR. Hypothyroidism in head and neck cancer patients: experimental and clinical observations. Laryngoscope 1994; 104:1-22.
84. Ladenson PW, Levin AA, Ridgeway EC, Daniels GH. Complications of surgery in hypothyroid patients. Am J Med 1984; 77:261-266.