Baseline evaluation of serum markers of inflammation and their utility in clinical practice in paediatric liver transplant recipients

Clinics and Research in Hepatology and Gastroenterology

Volumn 36, Issue 4, 2012, Pages 365-370

  Grammatikopoulos, Tassos ^a   Dhawan, Anil ^a   Bansal, Sanjay ^a   Wade, Jim ^b   Sherwood, Roy ^b   Dew, Tracy ^b   Heaton, Nigel ^b   Verma, Anita ^b  

^a KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^b KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; GAMMA GLUTAMYLTRANSFERASE; INTERLEUKIN 6; PROCALCITONIN;

ABDOMINAL INFECTION; ADOLESCENT; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BACTEREMIA; BILIRUBIN BLOOD LEVEL; CANDIDEMIA; CHEST INFECTION; CHILD; CLINICAL EVALUATION; CLINICAL PRACTICE; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GRAFT DYSFUNCTION; GRAFT RECIPIENT; GRAFT REJECTION; HUMAN; INFANT; INFLAMMATION; LIVER ABSCESS; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; RECEIVER OPERATING CHARACTERISTIC; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; SEPSIS; SURGICAL INFECTION; SYMPTOM; URINARY TRACT INFECTION; VIRUS LOAD;

ADOLESCENT; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CALCITONIN; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INFECTION; INFLAMMATION; INTERLEUKIN-6; LIVER TRANSPLANTATION; MALE; POSTOPERATIVE COMPLICATIONS; PROTEIN PRECURSORS;

EID: 84865962474     PISSN: 22107401     EISSN: 2210741X     Source Type: Journal    
DOI: 10.1016/j.clinre.2012.01.010     Document Type: Article

References (42)

1. Mimoz O., Benoist J.F., Edouard A.R., Assicot M., Bohuon C., Samii K. Procalcitonin and C-reactive protein during the early posttraumatic systemic inflammatory response syndrome. Intensive Care Med 1998, 24:185-188.
2. Meisner M., Tschaikowsky K., Hutzler A., Schick C., Schuttler J. Postoperative plasma concentrations of procalcitonin after different types of surgery. Intensive Care Med 1998, 24:680-684.
3. Chiesa C., Panero A., Rossi N., Stegagno M., De Giusti M., Osborn J.F., et al. Reliability of procalcitonin concentrations for the diagnosis of sepsis in critically ill neonates. Clin Infect Dis 1998, 26:664-672.
4. Muller B., Becker K.L., Schachinger H., Rickenbacher P.R., Huber P.R., Zimmerli W., et al. Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit. Crit Care Med 2000, 28:977-983.
5. Nylen E.S., O'Neill W., Jordan M.H., Snider R.H., Moore C.F., Lewis M., et al. Serum procalcitonin as an index of inhalation injury in burns. Horm Metab Res (Hormon-und Stoffwechselforschung) 1992, 24:439-443.
6. Oberhoffer M., Vogelsang H., Russwurm S., Hartung T., Reinhart K. Outcome prediction by traditional and new markers of inflammation in patients with sepsis. Clin Chem Lab Med 1999, 37:363-368.
7. Waydhas C., Nast-Kolb D., Jochum M., Trupka A., Lenk S., Fritz H., et al. Inflammatory mediators, infection, sepsis, and multiple organ failure after severe trauma. Arch Surg 1992, 127:460-467.
8. Dandona P., Nix D., Wilson M.F., Aljada A., Love J., Assicot M., et al. Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metabol 1994, 79:1605-1608.
9. Brunkhorst F.M., Heinz U., Forycki Z.F. Kinetics of procalcitonin in iatrogenic sepsis. Intensive Care Med 1998, 24:888-889.
10. Meisner M., Lohs T., Huettemann E., Schmidt J., Hueller M., Reinhart K. The plasma elimination rate and urinary secretion of procalcitonin in patients with normal and impaired renal function. Eur J Anaesthesiol 2001, 18:79-87.
11. Hesse D.G., Tracey K.J., Fong Y., Manogue K.R., Palladino M.A., Cerami A., et al. Cytokine appearance in human endotoxemia and primate bacteremia. Surg Gynecol Obstet 1988, 166:147-153.
12. Kishimoto T., Akira S., Narazaki M., Taga T. Interleukin-6 family of cytokines and gp130. Blood 1995, 86:1243-1254.
13. Tillet W.S., Francis T. Serological reactions in pneumonia with a non-protein somatic fraction of pneumococcus. J Exp Med 1930, 52:561-571.
14. Gewurz H. Biology of C-reactive protein and the acute phase response. Hosp Pract (Hosp Ed) 1982, 17:67-81.
15. Jaye D.L., Waites K.B. Clinical applications of C-reactive protein in pediatrics. Pediatr Infect Dis J 1997, 16:735-746. [quiz 746-737].
16. Young B., Gleeson M., Cripps A.W. C-reactive protein: a critical review. Pathology 1991, 23:118-124.
17. Ortega M., Rovira M., Filella X., Martinez J.A., Almela M., Puig J., et al. Prospective evaluation of procalcitonin in adults with non-neutropenic fever after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 2006, 37:499-502.
18. Svaldi M., Hirber J., Lanthaler A.I., Mayr O., Faes S., Peer E., et al. Procalcitonin-reduced sensitivity and specificity in heavily leucopenic and immunosuppressed patients. Br J Haematol 2001, 115:53-57.
19. Hammer C., Fraunberger P., Meiser B., Hammer S. Procalcitonin: a new marker for diagnosis of acute rejection and nonviral infection of heart and lung transplant patients. Transplant Proc 2001, 33:2204-2206.
20. Eyraud D., Ben Ayed S., Tanguy M.L., Vezinet C., Siksik J.M., Bernard M., et al. Procalcitonin in liver transplantation: are high levels due to donors or recipients?. Crit Care (London, England) 2008, 12:R85.
21. Fazakas J., Gondos T., Varga M., Sarvary E., Horovitz P., Perner F. Analysis of systemic and regional procalcitonin serum levels during liver transplantation. Transpl Int 2003, 16:465-470.
22. Jensen J.U., Lundgren J.D. Procalcitonin in liver transplant patients - yet another stone turned. Crit Care (London, England) 2008, 12:108.
23. Kuse E.R., Langefeld I., Jaeger K., Kulpmann W.R. Procalcitonin in fever of unknown origin after liver transplantation: a variable to differentiate acute rejection from infection. Crit Care Med 2000, 28:555-559.
24. Prieto B., Llorente E., Gonzalez-Pinto I., Alvarez F.V. Plasma procalcitonin measured by time-resolved amplified cryptate emission (TRACE) in liver transplant patients. A prognosis marker of early infectious and non-infectious postoperative complications. Clin Chem Lab Med 2008, 46(5):660-666.
25. Sauer M., Tiede K., Fuchs D., Gruhn B., Berger D., Zintl F. Procalcitonin C-reactive protein, and endotoxin after bone marrow transplantation: identification of children at high risk of morbidity and mortality from sepsis. Bone Marrow Transplant 2003, 31:1137-1142.
26. Coelho M.C., Tannuri U., Tannuri A.C., Reingenheim C., Troster E.J. Is procalcitonin useful to differentiate rejection from bacterial infection in the early post-operative period of liver transplantation in children?. Pediatr Transplant 2009, 13:1004-1006.
27. McLaughlin P.J., Aikawa A., Davies H.M., Ward R.G., Bakran A., Sells R.A., et al. Evaluation of sequential plasma and urinary tumor necrosis factor alpha levels in renal allograft recipients. Transplantation 1991, 51:1225-1229.
28. Tilg H., Nordberg J., Vogel W., Luger T.A., Herold M., Aulitzky W.E., et al. Circulating serum levels of interleukin 6 and C-reactive protein after liver transplantation. Transplantation 1992, 54:142-146.
29. Their M., Ronnholm K., Sairanen H., Holmberg C., Jalanko H. Serum C-reactive protein in pediatric kidney and liver transplant patients. Pediatr Transplant 2002, 6:153-160.
30. van Rossum A.M., Wulkan R.W., Oudesluys-Murphy A.M. Procalcitonin as an early marker of infection in neonates and children. Lancet Infect Dis 2004, 4:620-630.
31. Stryjewski G.R., Nylen E.S., Bell M.J., Snider R.H., Becker K.L., Wu A., et al. Interleukin-6, interleukin-8, and a rapid and sensitive assay for calcitonin precursors for the determination of bacterial sepsis in febrile neutropenic children. Pediatr Crit Care Med 2005, 6:129-135.
32. Sikora J.P., Chlebna-Sokol D., Krzyzanska-Oberbek A. Proinflammatory cytokines (IL-6, IL-8), cytokine inhibitors (IL-6sR, sTNFRII) and anti-inflammatory cytokines (IL-10, IL-13) in the pathogenesis of sepsis in newborns and infants. Archivum immunologiae et therapiae experimentalis 2001, 49:399-404.
33. Oppert M., Schindler R., Husung C., Offermann K., Graf K.J., Boenisch O., et al. Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit Care Med 2005, 33:2457-2464.
34. Quante T., Ng Y.C., Ramsay E.E., Henness S., Allen J.C., Parmentier J., et al. Corticosteroids reduce IL-6 in ASM cells via up-regulation of MKP-1. Am J Respir Cell Mol Biol 2008, 39:208-217.
35. Falagas M.E., Snydman D.R., Griffith J., Ruthazer R., Werner B.G. Effect of cytomegalovirus infection status on first-year mortality rates among orthotopic liver transplant recipients. The Boston Center for Liver Transplantation CMVIG study group. Ann Intern Med 1997, 126:275-279.
36. Kogan-Liberman D., Burroughs M., Emre S., Moscona A., Shneider B.L. The role of quantitative Epstein-Barr virus polymerase chain reaction and preemptive immunosuppression reduction in pediatric liver transplantation: a preliminary experience. J Pediatr Gastroenterol Nutr 2001, 33:445-449.
37. Zazula R., Prucha M., Tyll T., Kieslichova E. Induction of procalcitonin in liver transplant patients treated with anti-thymocyte globulin. Crit Care (London, England) 2007, 11:R131.
38. Group OMTS A randomized clinical trial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants. N Engl J Med 1985, 313:337-342.
39. Kuse E.R., Jaeger K. Procalcitonin increase after anti-CD3 monoclonal antibody therapy does not indicate infectious disease. Transplant Int 2001, 14:55.
40. Potapov E.V., Wagner F.D., Loebe M., Ivanitskaia E.A., Muller C., Sodian R., et al. Elevated donor cardiac troponin T and procalcitonin indicate two independent mechanisms of early graft failure after heart transplantation. Int J Cardiol 2003, 92:163-167.
41. Wagner F.D., Jonitz B., Potapov E., Qedra N., Wegscheider K., Weinmann E., et al. Procalcitonin: a donor-specific predictor of early graft failure and early graft failure mortality after heart transplantation. J Heart Lung Transplant 2001, 20:206.
42. Henley K.S., Lucey M.R., Appelman H.D., Baliga P., Brown K.A., Burtch G.D., et al. Biochemical and histopathological correlation in liver transplant: the first 180 days. Hepatology 1992, 16:688-693.