Long-term proteasomal inhibition in transgenic mice by UBB+1 expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients

Acta Neuropathologica

Volumn 124, Issue 2, 2012, Pages 187-197

  Irmler, Martin ^a   Gentier, Romina J G ^b   Dennissen, Frank J A ^b   Schulz, Holger ^a   Bolle, Ines ^a   Hölter, Sabine M ^a   Kallnik, Magdalena ^a   Cheng, Jing Jun ^b   Klingenspor, Martin ^c   Rozman, Jan ^a,c   Ehrhardt, Nicole ^a   Hermes, Denise J H P ^b   Gailus Durner, Valérie ^a   Fuchs, Helmut ^a   De Angelis, Martin Hrabě ^a,c   Meyer, Helmut E ^d   Hopkins, David A ^b   Van Leeuwen, Fred W ^b   Beckers, Johannes ^a,c  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Alzheimer's disease (AD); Central breathing control; Hypoxic response; Mouse model; Ubiquitin B (UBB+1); Ubiquitin proteasome system (UPS)

Indexed keywords

MESSENGER RNA; PROTEASOME; UBIQUITIN; UBIQUITIN B; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRAIN DYSFUNCTION; BRAIN REGION; BRAIN STEM RESPONSE; BREATHING PATTERN; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN TISSUE; HYPERCAPNIA; HYPOXIA; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NEUROPATHOLOGY; NONHUMAN; PARABRACHIAL NUCLEUS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RESPIRATION CONTROL; RESPIRATORY FAILURE; SOLITARY TRACT NUCLEUS; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANIMALS; BRAIN STEM; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MALE; MICE; MICE, TRANSGENIC; MIDDLE AGED; NEURONS; PHENOTYPE; PROTEASOME ENDOPEPTIDASE COMPLEX; RESPIRATION; UBIQUITIN;

EID: 84865865943     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-012-1003-7     Document Type: Article

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