Hypothyroxinemia during pregnancy: The effect on neurodevelopment in the child

International Journal of Developmental Neuroscience

Volumn 30, Issue 6, 2012, Pages 435-438

  Suárez Rodríguez, Marta ^a   Azcona San Julián, Cristina ^b   Alzina de Aguilar, Valentín ^b  

^a HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Hypothyroxinemia; Iodine intake; Neurodevelopment; Pregnancy

Indexed keywords

IODINE; THYROTROPIN; THYROXINE;

ADULT; ARTICLE; BRAIN DEVELOPMENT; CHILD; CHILD DEVELOPMENT; COGNITIVE INDEX; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MATERNAL DISEASE; MATERNAL HYPOTHYROXINEMIA; MEMORY COEFFICIENT; NERVOUS SYSTEM PARAMETERS; NEWBORN; PATIENT ASSESSMENT; PERCEPTUAL MANIPULATIVE COEFFICIENT; PRESCHOOL CHILD; PRIORITY JOURNAL; PSYCHOMOTOR DEVELOPMENT; SCORING SYSTEM; THIRD TRIMESTER PREGNANCY; THYROID DISEASE; THYROID FUNCTION; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

CHILD, PRESCHOOL; COGNITION DISORDERS; DEVELOPMENTAL DISABILITIES; FEMALE; HUMANS; HYPOTHYROIDISM; IODINE; MALE; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PRENATAL EXPOSURE DELAYED EFFECTS; PSYCHOMOTOR PERFORMANCE; RETROSPECTIVE STUDIES; THYROID GLAND;

EID: 84865862731     PISSN: 07365748     EISSN: 1873474X     Source Type: Journal    
DOI: 10.1016/j.ijdevneu.2012.07.004     Document Type: Article

References (23)

1. Akinci A., Sarac K., Güngör S., Mungan I., Aydin Ö., Branin M.R. Spectroscopy findings in neonates with hypothyroidism born to mothers living in iodine-deficient areas. American Journal of Neuroradiology 2006, 27:2083-2087.
2. Berbel P., Mestre J.L., Santamaría A., Palazón I., Franco A., Graells M., González-Torga A., de Escobar G.M. Delayed neurobehavioral development in children born to pregnant women with mild hypothyroxinemia during the first month of gestation: the importance of early iodine supplementation. Thyroid 2009, 19(5):511-519.
3. Bílek R., Bednar J., Zamrazil V. Spectrophotometric determination of urinary iodine by the Sandell-Kolthoff reaction subsequent to dry alkaline ashing. Results from the Czech Republic in the period 1994-2002. Clinical Chemistry and Laboratory Medicine 2005, 43:573-580.
4. Calvo R.M., Jauniaux E., Gulbis B., Asunción M., Gervy C., Contempré B., Morreale de Escobar G. Fetal tissues are exposed to biologically relevant free thyroxine concentrations during early phases of development. Possible consequences of maternal hypothyroxinemia. Journal of Clinical Endocrinology and Metabolism 2002, 87:1768-1777.
5. Contempré B., Jauniaux E., Calvo R., Jurkovic D., Campbell S., Morreale de Escobar G. Detection of thyroid hormones in human embryonic cavities during the first trimester of pregnancy. Journal of Clinical Endocrinology and Metabolism 1993, 77:1719-1722.
6. Díaz-Cadórniga F.J., Delgado E. Déficit de Yodo en España: Situación actual. Endocrinologie y Nutrition 2004, 51(1):14-25.
7. Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocrine Reviews 1997, 18:404-433.
8. Glinoer D. The regulation of thyroid function during normal pregnancy: importance of the iodine nutrition status. Best Practice and Research. Clinical Endocrinology and Metabolism 2004, 18(2):133-152.
9. Glinoer D., Delange F. The potential repercussions of maternal, fetal and neonatal hypothyroxinemia on the progeny. Thyroid 2000, 10(10):871-887.
10. Haddow J.E., Palomaki G.E., Allan W.C., Wiliams J.R., Knight G.J., Gagnon J., O'heir C.E., Mitchell M.L., Hermos R.J., Waisbren S.E., Faix J.D., Klein R.Z. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. New England Journal of Medicine 1999, 341(8):549-555.
11. Iskaros J., Pickard M., Evans I., Sinha A., Hardiman P., Ekins R. Thyroid hormone receptor gene expression in first trimester human fetal brain. Journal of Clinical Endocrinology and Metabolism 2000, 85:2620-2623.
12. Kooistra L., Crawford S., van Baar A.L., Brouwers E.P., Pop V.J. Neonatal effects of maternal hypothyroxinemia during early pregnancy. Pediatrics 2006, 117(1):161-167.
13. Lavado-Autric R., Ausó E., García-Velasco J.V., Arufe Mdel C., Escobar del Rey F., Berbel P., Morreale de Escobar G. Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny. Journal of Clinical Investigation 2003, 111(7):1073-1082.
14. Luton D., Huel C., Vuillard E., Leguy M.C., Tsatsaris V., Lewin F., Guibourdenche J. Assessment of thyroid hormones and androgens in amniotic fluid: clinical interest. Annales de Biologie Clinique 2009, 67(3):299-305.
15. a ed.
16. Moleti M., Lo Presti V.P., Mattina F., Mancuso A., De Vivo A., Giorgianni G., Di Bella B., Trimarchi F., Vermiglio F. Gestational thyroid function abnormalities in conditions of mild iodine deficiency: early screening versus continuous monitoring of maternal thyroid status. European Journal of Endocrinology/European Federation of Endocrine Societies 2009, 160(4):611-617.
17. Morreale de Escobar G. Yodo y embarazo. Yodo y Salud en el siglo XXI 2004, Editorial Médica s.l., Madrid, pp. 105-144.
18. Morreale G. Yodo y Embarazo. Progresos en Diagnóstico y Tratamiento Prenatal 2005, 17(3):129-146.
19. Oken E., Braverman L.E., Platek D., Mitchell M.L., Lee S.L., Pearce E.N. Neonatal thyroxine, maternal thyroid function, and child cognition. Journal of Clinical Endocrinology and Metabolism 2009, 94(2):497-503.
20. Pérez López F.R. Iodine and thyroid hormones during pregnancy and postpartum. Gynecological Endocrinology 2007, 23(7):414-428.
21. Pop V.J., Kuijpens J.L., van Baar A.L., Verkerk G., van Sons M.M., de Vijlder J.J., Vulsma T., Wiersinga W.M., Drexhage H.A., Vader H.L. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clinical Endocrinology 1999, 50(2):149-155.
22. Pop V.J., Brouwers E.P., Vader H.L., Vulsma T., van Baar A.L., de Vijlder J.J. Maternal hypothyroxinemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clinical Endocrinology (Oxf.) 2003, 59(3):282-288.
23. Williams G.R. Neurodevelopmental and neurophysiological actions of thyroid hormone. Journal of Neuroendocrinology 2008, 20:784-794.