Lack of cardiac nerve sprouting after intramyocardial transplantation of bone marrow-derived stem cells in a swine model of chronic ischemic myocardium

Journal of Cardiovascular Translational Research

Volumn 5, Issue 3, 2012, Pages 359-365

  Liu, Yuan ^a   Lai, Wing Hon ^a   Liao, Song Yan ^a   Siu, Chung Wah ^a,b   Yang, Yan Zong ^c   Tse, Hung Fat ^a,b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Arrhythmia; Bone marrow cells; Connecxin 43; Ischemia; Nerve sprouting

Indexed keywords

CONNEXIN 43; NEUROMODULIN; TYROSINE 3 MONOOXYGENASE; CD31 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; GAP JUNCTION; HEART MUSCLE ISCHEMIA; HEART NERVE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MONONUCLEAR CELL; NERVE SPROUTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWINE; SYMPATHETIC TONE; ANIMAL; BONE MARROW TRANSPLANTATION; CHRONIC DISEASE; CONVALESCENCE; DISEASE MODEL; ENDOTHELIUM CELL; HEART; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART STROKE VOLUME; INNERVATION; METABOLISM; MINIPIG; NERVOUS SYSTEM DEVELOPMENT; PATHOLOGY; PATHOPHYSIOLOGY; STEM CELL TRANSPLANTATION; TIME; TRANSPLANTATION;

ANIMALIA; SUIDAE;

ANIMALS; ANTIGENS, CD31; BONE MARROW TRANSPLANTATION; CHRONIC DISEASE; CONNEXIN 43; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; GAP-43 PROTEIN; HEART; MYOCARDIAL ISCHEMIA; MYOCARDIUM; NEUROGENESIS; RECOVERY OF FUNCTION; STEM CELL TRANSPLANTATION; STROKE VOLUME; SWINE; SWINE, MINIATURE; TIME FACTORS; TYROSINE 3-MONOOXYGENASE; VENTRICULAR FUNCTION, LEFT;

EID: 84865842065     PISSN: 19375387     EISSN: 19375395     Source Type: Journal    
DOI: 10.1007/s12265-012-9350-2     Document Type: Article

References (20)

1. Siu, C. W., Liao, S. Y., Liu, Y., Lian, Q., & Tse, H. F. (2010). Stem cells for myocardial repair. Thrombosis and Haemostasis, 104(1), 6-12.
2. Fuchs, S., Kornowski, R., Weisz, G., et al. (2006). Safety and feasibility of transendocardial autologous bone marrow cell transplantation in patients with advanced heart disease. The American Journal of Cardiology, 97(6), 823-829.
3. Gavira, J. J., Nasarre, E., Abizanda, G., et al. (2010). Repeated implantation of skeletal myoblast in a swine model of chronic myocardial infarction. European Heart Journal, 31(8), 1013-1021.
4. Tse, H. F., Siu, C. W., Zhu, S. G., et al. (2007). Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium. European Journal of Heart Failure, 9(8), 747-753.
5. Tse, H. F., Thambar, S., Kwong, Y. L., et al. (2007). Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases (PROTECT-CAD trial). European Heart Journal, 28(24), 2998-3005. (Pubitemid 350262782)
6. Van Ramshorst, J., Bax, J. J., Beeres, S. L., et al. (2009). Intramyocardial bone marrow cell injection for chronic myocardial ischemia: A randomized controlled trial. Journal of the American Medical Association, 301(19), 1997-2004.
7. Losordo, D. W., Henry, T. D., Davidson, C., et al. (2011). Intramyocardial, autologous CD34+ cell therapy for refractory angina. Circulation Research, 109(4), 428-436.
8. Liao, S. Y., Liu, Y., Siu, C. W., et al. (2010). Proarrhythmic risk of embryonic stem cell-derived cardiomyocyte transplantation in infarcted myocardium. Heart Rhythm, 7(12), 1852-1859.
9. Gepstein, L., Ding, C., Rehemedula, D., et al. (2010). In vivo assessment of the electrophysiological integration and arrhythmogenic risk of myocardial cell transplantation strategies. Stem Cells, 28(12), 2151-2161.
10. Cao, J. M., Chen, L. S., Kenknight, B. H., et al. (2000). Nerve sprouting and sudden cardiac death. Circulation Research, 86(7), 816-821. (Pubitemid 30217832)
11. Lai, A. C., Wallner, K., Cao, J. M., et al. (2000). Colocalization of tenascin and sympathetic nerves in a canine model of nerve sprouting and sudden cardiac death. Journal of Cardiovascular Electrophysiology, 11(12), 1345-1351. (Pubitemid 32016858)
12. Cao, J. M., Fishbein, M. C., Han, J. B., et al. (2000). Relationship between regional cardiac hyperinnervation and ventricular arrhythmia. Circulation, 101(16), 1960-1969. (Pubitemid 30225278)
13. Pak, H. N., Qayyum, M., Kim, D. T., et al. (2003). Mesenchymal stem cell injection induces cardiac nerve sprouting and increased tenascin expression in a swine model of myocardial infarction. Journal of Cardiovascular Electrophysiology, 14(8), 841-848. (Pubitemid 36994105)
14. Kim, S. K., Pak, H. N., Park, J. H., et al. (2010). Cardiac cell therapy with mesenchymal stem cell induces cardiac nerve sprouting, angiogenesis, and reduced connexin43-positive gap junctions, but concomitant electrical pacing increases connexin43-positive gap junctions in canine heart. Cardiology in the Young, 20(3), 308-317.
15. Meiri, K. F., Pfenninger, K. H., & Willard, M. B. (1986). Growthassociated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp 46, a major polypeptide of a subcellular fraction enriched in growth cones. Proc Natl Acad Sci USA, 83(10), 3537-3541. (Pubitemid 16043070)
16. Li, W., Knowlton, D., Van Winkle, D. M., & Habecker, B. A. (2004). Infarction alters both the distribution and noradrenergic properties of cardiac sympathetic neurons. American Journal of Physiology -Heart and Circulatory Physiology, 286(6), H2229-H2236. (Pubitemid 38685237)
17. Kim, S. U., & De Vellis, J. (2009). Stem cell-based cell therapy in neurological diseases: A review. Journal of Neuroscience Research, 87(10), 2183-2200.
18. Wen, Z., Zheng, S., Zhou, C., Wang, J., & Wang, T. (2011). Repair mechanisms of bone marrow mesenchymal stem cells in myocardial infarction. Journal of Cellular and Molecular Medicine, 15(5), 1032-1043.
19. Decrock, E., Vinken, M., De Vuyst, E., et al. (2009). Connexinrelated signaling in cell death: To live or let die? Cell Death and Differentiation, 16(4), 524-536.
20. Miura, T., Miki, T., & Yano, T. (2010). Role of the gap junction in ischemic preconditioning in the heart. American Journal of Physiology Heart and Circulatory Physiology, 298(4), H1115-H1125.