Effects of intracoronary delivery of allogenic bone marrow-derived stem cells expressing heme oxygenase-1 on myocardial reperfusion injury

Thrombosis and Haemostasis

Volumn 108, Issue 3, 2012, Pages 464-475

  Wojakowski, Wojciech ^a   Tendera, Michal ^a   Cybulski, Wieslaw ^a   Zuba Surma, Ewa K ^b   Szade, Krzysztof ^b   Florczyk, Urszula ^b   Kozakowska, Magdalena ^b   Szymula, Agnieszka ^b   Krzych, Lukasz ^a   Paslawska, Urszula ^c   Paslawski, Robert ^d   Milewski, Krzysztof ^e   Buszman, Piotr P ^e   Nabialek, Edyta ^a   Kuczmik, Waclaw ^a   Janiszewski, Adrian ^f   Dziegiel, Piotr ^d   Buszman, Pawel E ^d   Józkowicz, Alicja ^b   Dulak, Jozef ^b  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

^b JAGIELLONIAN UNIVERSITY   (Poland)

^c WROC AW UNIVERSITY OF ENVIRONMENTAL AND LIFE SCIENCES   (Poland)

^d WROCLAW MEDICAL UNIVERSITY   (Poland)

^e American Heart of Poland ^*  (Poland)

^f Wojewodzki Szpital Specjalistyczny   (Poland)

Author keywords

Bone marrow cells; Gene therapy; Heme oxygenase 1; Myocardial infarction; Reperfusion

Indexed keywords

ADENOVIRUS VECTOR; ELONGATION FACTOR 2; HEME OXYGENASE 1; INTERLEUKIN 6; MICRORNA; MICRORNA 133A; MICRORNA 21; MICRORNA 29A; STROMAL CELL DERIVED FACTOR 1; TROPONIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLOGENEIC STEM CELL TRANSPLANTATION; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENETIC TRANSDUCTION; HEART HEMODYNAMICS; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEMATOPOIETIC STEM CELL; HISTOPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHORTENING FRACTION; SWINE; TRANSTHORACIC ECHOCARDIOGRAPHY;

ADENOVIRIDAE; ANIMALS; BONE MARROW TRANSPLANTATION; CORONARY VESSELS; CYTOKINES; GENE EXPRESSION PROFILING; GENES, REPORTER; GENETIC VECTORS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HEME OXYGENASE (DECYCLIZING); INJECTIONS, INTRA-ARTERIAL; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RECOMBINANT FUSION PROTEINS; STROKE VOLUME; SUS SCROFA; SWINE; TRANSDUCTION, GENETIC; TRANSPLANTATION, HOMOLOGOUS;

EID: 84865825093     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH12-05-0303     Document Type: Article

References (37)

1. Keeley EC, Boura JA, Grines CL. Primary angioplasty versus intravenous throm-bolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet 2003; 361:13-20.
2. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med 2007; 357: 1121-1135.
3. Gerczuk PZ, Kloner RA. An update on cardioprotection: a review of the latest ad-junctive therapies to limit myocardial infarction size in clinical trials. J Am Coll Cardiol 2012; 59: 969-978.
4. Clifford DM, Fisher SA, Brunskill SJ, et al. Stem cell treatment for acute myocardial infarction. Cochrane Database Syst Rev 2012; 2: CD006536.
5. Ratajczak MZ, Kucia M, Jadczyk T, et al. Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies? Leukemia 2011; epub ahead of print.
6. Dulak J, Deshane J, Jozkowicz A, et al. Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis. Circulation 2008; 117:231-241.
7. Wu ML, Ho YC, Yet SF A central role of heme oxygenase-1 in cardiovascular protection. AntioxidRedox Signal 2011; 15:1835-1846.
8. Liu X, Wei J, Peng DH, et al. Absence of heme oxygenase-1 exacerbates myocardial ischemia/reperfusion injury in diabetic mice. Diabetes 2005; 54: 778-784.
9. Lakkisto P, Palojoki E, Backlund T, et al. Expression of heme oxygenase-1 in response to myocardial infarction in rats. J Mol Cell Cardiol 2002; 34: 1357-1365.
10. Tang YL, Tang Y, Zhang YC, et al. Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J Am Coll Cardiol 2005; 46: 1339-1350.
11. Grochot-Przeczek ALR, Mis J, Skrzypek K, et al. Heme oxygenase-1 accelerates cutaneous wound healing in mice. PLoS ONE 2012; 4: e5803.
12. Buszman PP, Wojakowski W, Milewski K, et al. Controlled Reperfusion with Intravenous Bivalirudin and Intracoronary Abciximab Combination Therapy in the Porcine Myocardial Infarction Model. Thromb Res 2011; epub ahead of print.
13. Drexler H, Meyer GP, Wollert KC. Bone-marrow-derived cell transfer after ST-elevation myocardial infarction: lessons from the BOOST trial. Nat Clin Pract Cardiovasc Med 2006; 3 (Suppl 1): S65-68.
14. Fischer-Rasokat U, Honold J, Seeger FH, et al. Early remodeling processes as predictors of diastolic function 5 years after reperfused acute myocardial infarction and intracoronary progenitor cell application. Clin Res Cardiol 2012; 101: 209-216.
15. Jiang YB, Zhang XL, Tang YL, et al. Effects of heme oxygenase-1 gene mo dulated mesenchymal stem cells on vasculogenesis in ischemic swine hearts. Chin Med J (Engl)2011; 124:401-407.
16. Zeng B, Lin G, Ren X, et al. Over-expression of HO-1 on mesenchymal stem cells promotes angiogenesis and improves myocardial function in infarcted myocardium. J Biomed Sci 2010; 17: 80.
17. Shu T, Zeng B, Ren X, et al. HO-1 modified mesenchymal stem cells modulate MMPs/TIMPs system and adverse remodeling in infarcted myocardium. Tissue Cell 2010; 42: 217-222.
18. Tsubokawa T, Yagi K, Nakanishi C, et al. Impact of anti-apoptotic and anti-ox-idative effects of bone marrow mesenchymal stem cells with transient over-expression of heme oxygenase- Ion myocardial ischemia. Am J Physiol Heart Circ Physiol 2010; 298: H1320-1329.
19. Zeng B, Ren X, Lin G, et al. Paracrine action of HO-1-modified mesenchymal stem cells mediates cardiac protection and functional improvement. Cell Biol Int 2008; 32: 1256-1264.
20. Mullenix PS, Huddleston SJ, Stojadinovic A, et al. A new heart: Somatic stem cells and myocardial regeneration. J Surg Oncol 2012; 105: 475-480.
21. Hofmann M, Wollert KC, Meyer GP, et al. Monitoring of bone marrow cell homing into the infarcted human myocardium. Circulation 2005; 111:2198-2202.
22. Barbash IM, Chouraqui P, Baron J, et al. Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution. Circulation 2003; 108: 863-868.
23. Nagaya N, Kangawa K, Itoh T, et al. Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation 2005; 112:1128-1135.
24. Li Q, Guo Y, Ou Q, et al. Gene transfer as a strategy to achieve permanent cardio-protection II: rAAV-mediated gene therapy with heme oxygenase-1 limits infarct size 1 year later without adverse functional consequences. Basic Res Cardiol 2011; 106: 1367-1377.
25. Juhasz B, Varga B, Czompa A, et al. Postischemic cardiac recovery in heme oxygenase- 1 transgenic ischemic/reperfused mouse myocardium. J Cell Mol Med 2011; 15:1973-1982.
26. Novo G, Cappello F, Rizzo M, et al. Hsp60 and heme oxygenase-1 (Hsp32) in acute myocardial infarction. Transl Res 2011; 157: 285-292.
27. Yang JJ, Yang X, Liu ZQ, et al. Transplantation of adipose tissue-derived stem cells overexpressing heme oxygenase-1 improves functions and remodeling of infarcted myocardium in rabbits. Tohoku J Exp Med 2012; 226:231-241.
28. Liu X, Simpson JA, Brunt KR, et al. Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarction. Am J Physiol Heart Circ Physiol 2007; 293: H48-59.
29. Liu X, Pachori AS, Ward CA, et al. Heme oxygenase-1 (HO-1) inhibits postmyoc-ardial infarct remodeling and restores ventricular function. FASEB J 2006; 20: 207-216.
30. Lakkisto P, Kyto V, Forsten H, et al. Heme oxygenase-1 and carbon monoxide promote neovascularization after myocardial infarction by modulating the expression of HIF-lalpha, SDF-lalpha and VEGF-B. Eur J Pharmacol 2010; 635: 156-164.
31. Jiang Y, Chen L, Tang Y, et al. HO-1 gene overexpression enhances the beneficial effects of superparamagnetic iron oxide labeled bone marrow stromal cells transplantation in swine hearts underwent ischemia/reperfusion: an MRI study. Basic Res Cardiol 2010; 105:431-442.
32. Zeng B, Chen H, Zhu C, et al. Effects of combined mesenchymal stem cells and heme oxygenase-1 therapy on cardiac performance. Eur J Cardiothorac Surg 2008; 34: 850-856.
33. Lakkisto P, Siren JM, Kyto V, et al. Heme oxygenase-1 induction protects the heart and modulates cellular and extracellular remodelling after myocardial infarction in rats. Exp Biol Med 2011; 236:1437-1448.
34. Tuuminen R, Syrjala S, Krebs R, et al. Donor simvastatin treatment abolishes rat cardiac allograft ischemia/reperfusion injury and chronic rejection through microvascular protection. Circulation 2011; 124: 1138-1150.
35. Liu SX, Zhang Y, Wang YF,etal.Upregulation of hemeoxygenase-1 expression by hydroxysafflor yellow A conferring protection from anoxia/reoxygenation-in-duced apoptosis in H9c2 cardiomyocytes. Int J Cardiol 2011; epub ahead of print.
36. Stein AB, Bolli R, Dawn B, et al. Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium. J Mol Cell Cardiol 2012; 52: 228-236.
37. Wang G, Hamid T, Keith RJ, et al. Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart. Circulation 2010; 121:1912-1925.