Correlations among symptoms, signs, and clinical tests in evaporative-type dry eye disease caused by Meibomian Gland Dysfunction (MGD)

Current Eye Research

Volumn 37, Issue 10, 2012, Pages 855-863

  Cuevas, Miguel ^a   González García, María J ^a,b   Castellanos, Evangelina ^a   Quispaya, Rolando ^a   Parra, Paola De La ^a   Fernández, Itziar ^b,c   Calonge, Margarita ^a,b  

^a UNIVERSITY OF VALLADOLID   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^c UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

Blepharitis; Dry eye diagnostic tests; Dry eye disease; Dry eye questionnaires; Meibomian gland dysfunction

Indexed keywords

FLUORESCEIN; LYSOZYME; PHENOLSULFONPHTHALEIN; ROSE BENGAL;

ADULT; AGED; ARTICLE; BEST CORRECTED VISUAL ACUITY; CLINICAL ARTICLE; CONJUNCTIVAL HYPEREMIA; CONTRAST SENSITIVITY; CORRELATION ANALYSIS; DRY EYE; EVAPORATIVE TYPE DRY EYE DISEASE; EYE EXAMINATION; FEMALE; FLUORESCENCE ANALYSIS; HUMAN; LID MARGIN ASSESSMENT; MALE; MEIBOMIAN GLAND DYSFUNCTION; PHENOL RED THREAD TEST; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUESTIONNAIRE; SCHIRMER TEST; SEBACEOUS GLAND DISEASE; STAINING; SYMPTOMATOLOGY; TEAR BREAK UP TIME; TEAR MENISCUS HEIGHT; VISUAL ACUITY; VISUAL SYSTEM PARAMETERS;

ADULT; AGED; BLEPHARITIS; CONTRAST SENSITIVITY; CROSS-SECTIONAL STUDIES; DRY EYE SYNDROMES; FEMALE; FLUORESCENT DYES; HUMANS; HYPEREMIA; MALE; MEIBOMIAN GLANDS; MIDDLE AGED; MURAMIDASE; OPHTHALMIC SOLUTIONS; PROSPECTIVE STUDIES; QUESTIONNAIRES; ROSE BENGAL; TEARS; VISUAL ACUITY;

EID: 84865792773     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.3109/02713683.2012.683508     Document Type: Article

References (47)

1. Lemp MA, Baudouin C, Baum J, et al. The definition and classification of dry eye disease: Report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007;5:75-92.
2. Khanal S, Tomlinson A, McFadyen A et al. Dry eye diagnosis. Invest Ophthalmol Vis Sci 2008;49:1407-1414.
3. Sullivan BD, Whitmer D, Nichols KK et al. An objective approach to dry eye disease severity. Invest Ophthalmol Vis Sci 2010;51:6125-6130.
4. Kallarackal GU, Ansari EA, Amos N et al. A comparative study to assess the clinical use of Fluorescein Meniscus Time (FMT) with Tear Break up Time (TBUT) and Schirmer's tests (ST) in the diagnosis of dry eyes. Eye (Lond) 2002;16:594-600.
5. Nichols KK. Patient-reported symptoms in dry dye disease. Ocul Surf 2006;4:137-145.
6. Schein OD, Tielsch JM, Munoz B et al. Relation between signs and symptoms of dry eye in the elderly. A population-based perspective. Ophthalmology 1997;104:1395-1401.
7. Hay EM, Thomas E, Pal B et al. Weak association between subjective symptoms or and objective testing for dry eyes and dry mouth: Results from a population based study. Ann Rheum Dis 1998;57:20-24.
8. Begley CG, Chalmers RL, Abetz L et al. The relationship between habitual patient-reported symptoms and clinical signs among patients with dry eye of varying severity. Invest Ophthalmol Vis Sci 2003;44:4753-4761.
9. Nichols KK, Nichols JJ, Mitchell GL. The lack of association between signs and symptoms in patients with dry eye disease. Cornea 2004;23:762-770.
10. Lin PY, Cheng CY, Hsu WM et al. Association between symptoms and signs of dry eye among an elderly Chinese population in Taiwan: The Shihpai Eye Study. Invest Ophthalmol Vis Sci 2005;46:1593-1598.
11. Nelson JD, Shimazaki J, Benitez-del-Castillo JM et al. The international workshop on meibomian gland dysfunction: Report of the definition and classification subcommittee. Invest Ophthalmol Vis Sci 2011;52:1930-1937.
12. Smith JA, Albeitz J, Begley CG, et al. The epidemiology of dry eye disease: Report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007;5:93-107.
13. Lemp MA, Nichols KK. Blepharitis in the United States 2009: A survey-based perspective on prevalence and treatment. Ocul Surf 2009;7:S1-S14.
14. Gulati A, Sullivan R, Buring JE et al. Validation and repeatability of a short questionnaire for dry eye syndrome. Am J Ophthalmol 2006;142:125-131.
15. Efron N. Grading scales for contact lens complications. Ophthalmic Physiol Opt 1998;18:182-186.
16. Patel S, Farrell J, Blades KJ et al. The value of a phenol red impregnated thread for differentiating between the aqueous and non-aqueous deficient dry eye. Ophthalmic Physiol Opt 1998;18:471-476.
17. Cho P, Brown B. Review of the tear break-up time and a closer look at the tear break-up time of Hong Kong Chinese. Optom Vis Sci 1993;70:30-38.
18. Oguz H, Yokoi N, Kinoshita S. The height and radius of the tear meniscus and methods for examining these parameters. Cornea 2000;19:497-500.
19. Bron AJ, Smith J, Calonge M, et al. Methodologies to diagnose and monitor dry eye disease: Report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007;5:108-152.
20. Bron AJ. The Doyne Lecture. Reflections on the tears. Eye (Lond) 1997;11 (Pt 5):583-602.
21. deLuise VP, Tabbara KF. Quantitation of tear lysozyme levels in dry-eye disorders. Arch Ophthalmol 1983;101:634-635.
22. Velos P, Cherry PM, Miller D. An improved method for measuring human tear lysozyme concentration. Arch Ophthalmol 1985;103:31-33.
23. Herreras JM, Perez S, Perez H et al. Influence of topical anesthesia on tests diagnostic of blepharitis-associated dry eye syndrome. Ocul Immunol Inflamm 1997;5:33-41.
24. McCulley JP, Dougherty JM, Deneau DG. Classification of chronic blepharitis. Ophthalmology 1982;89:1173-1180.
25. Jackson WB. Blepharitis: Current strategies for diagnosis and management. Can J Ophthalmol 2008;43:170-179.
26. Korb DR, Henriquez AS. Meibomian gland dysfunction and contact lens intolerance. J Am Optom Assoc 1980;51:243-251.
27. Norn M. Expressibility of meibomian secretion. Relation to age, lipid precorneal film, scales, foam, hair and pigmentation. Acta Ophthalmol (Copenh) 1987;65:137-142.
28. Bron AJ, Benjamin L, Snibson GR. Meibomian gland disease. Classification and grading of lid changes. Eye (Lond) 1991;5 (Pt 4):395-411.
29. Shimazaki J, Sakata M, Tsubota K. Ocular surface changes and discomfort in patients with meibomian gland dysfunction. Arch Ophthalmol 1995;113:1266-1270.
30. Alvarenga LS, Mannis MJ. Ocular rosacea. Ocul Surf 2005;3:41-58.
31. Efron B, Tibshirani R. Confidence intervals based on bootstrap percentiles. In: Efron B, Tibshirani R (eds), An introduction to the bootstrap, New York: Chapman and Hill; 1993:168-177.
32. R Development Core Team. R: A language and environment for statistical computing. 2010. Available at: Http://www.Rproject. org. Accessed October 2011.
33. McMonnies CW, Ho A. Patient history in screening for dry eye conditions. J Am Optom Assoc 1987;58:296-301.
34. Schiffman RM, Christianson MD, Jacobsen G, Hirsch JD, Reis BL. Reliability and validity of the Ocular Surface Disease Index. Arch Ophthalmol 2000;118:615-621.
35. Nichols KK, Nichols JJ, Mitchell GL. The reliability and validity of McMonnies Dry Eye Index. Cornea 2004;23:365-371.
36. Schaumberg DA, Gulati A, Mathers WD et al. Development and validation of a short global dry eye symptom index. Ocul Surf 2007;5:50-57.
37. Chalmers RL, Begley CG, Caffery B. Validation of the 5-Item Dry Eye Questionnaire (DEQ-5): Discrimination across selfassessed severity and aqueous tear deficient dry eye diagnoses. Cont Lens Anterior Eye 2010;33:55-60.
38. Gonzalez-Garcia MJ, Gonzalez-Saiz A, de la Fuente B et al. Exposure to a controlled adverse environment impairs the ocular surface of subjects with minimally symptomatic dry eye. Invest Ophthalmol Vis Sci 2007;48:4026-4032.
39. Montes-Mico R, Caliz A, Alio JL. Wavefront analysis of higher order aberrations in dry eye patients. J Refract Surg 2004;20:243-247.
40. Montes-Mico R, Alio JL, Charman WN. Dynamic changes in the tear film in dry eyes. Invest Ophthalmol Vis Sci 2005;46:1615-1619.
41. Ishida R, Kojima T, Dogru M et al. The application of a new continuous functional visual acuity measurement system in dry eye syndromes. Am J Ophthalmol 2005;139: 253-258.
42. Ghanem VC, Mehra N, Wong S et al. The prevalence of ocular signs in acne rosacea: Comparing patients from ophthalmology and dermatology clinics. Cornea 2003;22:230-233.
43. Tomlinson A, Bron AJ, Korb DR et al. The international workshop on meibomian gland dysfunction: Report of the diagnosis subcommittee. Invest Ophthalmol Vis Sci 2011;52: 2006-2049.
44. Driver PJ, Lemp MA. Meibomian gland dysfunction. Surv Ophthalmol 1996;40:343-367.
45. Moore JE, Graham JE, Goodall EA et al. Concordance between common dry eye diagnostic tests. Br J Ophthalmol 2009;93:66-72.
46. Behrens A, Doyle JJ, Stern L et al.; Dysfunctional tear syndrome study group. Dysfunctional tear syndrome: A Delphi approach to treatment recommendations. Cornea 2006;25:900-907.
47. Smith J, Nichols KK, Baldwin EK. Current patterns in the use of diagnostic tests in dry eye evaluation. Cornea 2008;27:656-662.