Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors

European Journal of Medicinal Chemistry

Volumn 55, Issue , 2012, Pages 32-38

  Yao, Chun Hsu ^a   Song, Jen Shin ^a   Chen, Chiung Tong ^a   Yeh, Teng Kuang ^a   Hsieh, Tsung Chih ^a   Wu, Szu Huei ^a   Huang, Chung Yu ^a   Huang, Yu Lin ^a   Wang, Min Hsien ^a   Liu, Yu Wei ^a   Tsai, Chi Hui ^a   Kumar, Chidambaram Ramesh ^a   Lee, Jinq Chyi ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

C indolylxylosides; Sodium dependent glucose co transporter; Structure activity relationship; Type 2 diabetes mellitus

Indexed keywords

1 (2 NAPHTHYLMETHYL) 3 (BETA DEXTRO XYLOPYRANOSYL) 1H INDOLE; 1 (4 CYCLOPROPYLBENZYL) 3 (BETA DEXTRO XYLOPYRANOSYL) 1H INDOLE; 1 (4 CYCLOPROPYLBENZYL) 7 FLUORO 3 (BETA DEXTRO XYLOPYRANOSYL) 1H INDOLE; 1 (4 CYCLOPROPYLBENZYL) 7 METHYL 3 (BETA DEXTRO XYLOPYRANOSYL) 1H INDOLE; 1 (4 FLUOROBENZYL) 3 (BETA DEXTRO XYLOPYRANOSYL) 1H INDOLE; 1 (4 METHOXYBENZYL) 3 (BETA DEXTRO XYLOPYRANOSYL) 1H INDOLE; 1 (4 PROPYLBENZYL) 3 (BETA DEXTRO XYLOPYRANOSYL) 1H INDOLE; 1 (4 TERT BUTYLBENZYL) 3 (BETA DEXTRO XYLOPYRANOSYL) 1H INDOLE; 1 BENZYL 3 (BETA DEXTRO XYLOPYRANOSYL) 1H INDOLE; 4 CHLORO 3 (4 CYCLOPROPYLBENZYL) 1 (BETA DEXTRO XYLOPYRANOSYL) 1H INDOLE; 4 FLUORO 1 (4 METHOXYBENZYL) 3 (BETA DEXTRO XYLOPYRANOSYL) 1H INDOLE; 7 FLUORO 1 (4 METHOXYBENZYL) 3 (BETA DEXTRO XYLOPYRANOSYL) 1H INDOLE; ANTIDIABETIC AGENT; C LINKED INDOLYLXYLOSIDE BASED SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; DAPAGLIFLOZIN; GLUCOSE; INDOLE DERIVATIVE; PHENYL GROUP; PROTEIN INHIBITOR; SODIUM GLUCOSE COTRANSPORTER 1; SODIUM GLUCOSE COTRANSPORTER 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENCY; DRUG SCREENING; DRUG STABILITY; GLUCOSE BLOOD LEVEL; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; SINGLE DRUG DOSE; STREPTOZOCIN DIABETES; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CHEMISTRY TECHNIQUES, SYNTHETIC; CHO CELLS; CRICETINAE; CRICETULUS; DRUG STABILITY; GLYCOSIDES; HUMANS; HYPOGLYCEMIC AGENTS; INHIBITORY CONCENTRATION 50; MALE; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-GLUCOSE TRANSPORTER 1; SODIUM-GLUCOSE TRANSPORTER 2;

EID: 84865785537     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.06.053     Document Type: Article

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