Determination of salbutamol in human plasma and urine using liquid chromatography coupled to tandem mass spectrometry and its pharmacokinetic study

Biomedical Chromatography

Volumn 26, Issue 10, 2012, Pages 1176-1182

  Zhang, Dujuan ^a   Teng, Yanni ^a   Chen, Keguang ^a   Liu, Sha ^a   Wei, Chunmin ^a   Wang, Benjie ^a   Yuan, Guiyan ^a   Zhang, Rui ^a   Liu, Xiaoyan ^a   Guo, Ruichen ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Acetaminophen; LC MS MS; Pharmacokinetics; Salbutamol

Indexed keywords

LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA (HUMAN); POSITIVE IONS; SULFUR COMPOUNDS;

ACETAMINOPHEN; HUMAN PLASMAS; HUMAN URINE; INTERNAL STANDARDS; LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY COUPLED TO TANDEM MASS SPECTROMETRY; PHARMACOKINETIC STUDIES; SALBUTAMOL; SELECTIVE LIQUID CHROMATOGRAPHY;

PHARMACOKINETICS;

ACETIC ACID ETHYL ESTER; PARACETAMOL; SALBUTAMOL SULFATE;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CHINESE; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MALE; MAXIMUM PLASMA CONCENTRATION; PLASMA CONCENTRATION-TIME CURVE; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 84865780575     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2675     Document Type: Article

References (12)

1. Du XL, Zhu Z, Fu Q, Li DK and Xu WB. Pharmacokinetics and relative bioavailability of salbutamol metered-dose inhaler in healthy volunteers. Acta Pharmacologica Sinica 2002; 23: 663-666.
2. Elers J, Pedersen L, Henninge J, Lund TK, Hemmersbach P, Dalhoff K and Backer V. Blood and urinary concentrations of salbutamol in asthmatic subjects. Medicine and Science in Sports and Exercise 2010; 42: 244-249.
3. Fowler SJ and Lipworth BJ. Pharmacokinetics and systemic beta2-adrenoceptor-mediated responses to inhaled salbutamol. British Journal of Clinical Pharmacology 2001; 51: 359-362.
4. Garcia P, Paris AC, Gil J, Popot MA and Bonnaire Y. Analysis of β-agonists by HPLC/ESI-MS(n) in horse doping control. Biomedical Chromatography 2011; 25: 147-154.
5. Jacobson GA, Chong FV and Davies NW. LC-MS method for the determination of albuterol enantiomers in human plasma using manual solid-phase extraction and a non-deuterated internal standard. Journal of Pharmaceutical and Biomedical Analysis 2003; 31: 1237-1243.
6. Kavita GS, Donald JK, Sidney DG, Patrick K and William JJ. Pharmacokinetics and pharmacodynamics of cumulative single doses of inhaled salbutamol enantiomers in asthmatic subjects. Pulmonary Pharmacology & Therapeutics 1999; 12: 353-362.
7. Loss JR 2nd, Orzechowski RF and Hock RS. Measurement of albuterol in guinea pig serum by high performance liquid chromatography with fluorescence detection. Biomedical Chromatography 2000; 14: 1-5.
8. Mazhar SH and Chrystyn H. New HPLC assay for urinary salbutamol concentrations in samples collected post-inhalation. Journal of Pharmaceutical and Biomedical Analysis 2009; 50: 175-182.
9. Narasimha Murthy S and Hiremath SR. Clinical pharmacokinetic and pharmacodynamic evaluation of transdermal drug delivery systems of salbutamol. International Journal of Pharmaceutics 2004; 287: 47-53.
10. Ouyang J, Duan JL, Baeyens WR and Delanghe JR. A simple method for the study of salbutamol pharmacokinetics by ion chromatography with direct conductivity detection. Talanta 2005; 65: 1-6.
11. Schmekel B, Rydberg I, Norlander B, Sjöswärd KN, Ahlner J and Andersson RG. Stereoselective pharmacokinetics of S-salbutamol after administration of the racemate in healthy volunteers. European Respiratory Journal 1999; 13: 1230-1235.
12. Servais AC, Fillet M, Mol R, Somsen GW, Chiap P, de Jong GJ and Crommen J. On-line coupling of cyclodextrin mediated nonaqueous capillary electrophoresis to mass spectrometry for the determination of salbutamol enantiomers in urine. Journal of Pharmaceutical and Biomedical Analysis 2006; 40: 752-757.