Investigating the Efficacy of Subharmonic Aided Pressure Estimation for Portal Vein Pressures and Portal Hypertension Monitoring

Ultrasound in Medicine and Biology

Volumn 38, Issue 10, 2012, Pages 1784-1798

  Dave, Jaydev K ^a,b   Halldorsdottir, Valgerdur G ^a,b   Eisenbrey, John R ^a   Merton, Daniel A ^a   Liu, Ji Bin ^a   Zhou, Jian Hua ^a   Wang, Hsin Kai ^a   Park, Suhyun ^c   Dianis, Scott ^c   Chalek, Carl L ^c   Lin, Feng ^c   Thomenius, Kai E ^c   Brown, Daniel B ^a   Forsberg, Flemming ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b DREXEL UNIVERSITY   (United States)

^c GE GLOBAL RESEARCH   (United States)

Author keywords

Noninvasive pressure estimation; Portal hypertension; Subharmonic imaging; Subharmonic aided pressure estimation; Ultrasound contrast agents

Indexed keywords

ACOUSTIC POWER; GE HEALTHCARES; HOUSTON; MICROBUBBLES; PH MODEL; PORTAL HYPERTENSION; PORTAL VEINS; PRESSURE CHANGE; PRESSURE ESTIMATION; PRESSURE MONITORING; RADIO-FREQUENCY DATUM; STATISTICALLY SIGNIFICANT DIFFERENCE; SUBHARMONIC EMISSIONS; SUBHARMONIC IMAGING; SUBHARMONIC MODES; SUBHARMONIC SIGNALS; SUBHARMONICS; ULTRASOUND CONTRAST AGENT;

BUBBLES (IN FLUIDS); CATHETERS; HEALTH CARE;

ESTIMATION;

PERFLUBUTANE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B SCAN; BIOLOGICAL MONITORING; BLOOD PRESSURE MEASUREMENT; CLINICAL EFFECTIVENESS; COLOR ULTRASOUND FLOWMETRY; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DIAGNOSTIC TEST ACCURACY STUDY; DOG; ECHOGRAPHY; INTERMETHOD COMPARISON; LIVER CIRRHOSIS; MICROBUBBLE; NON INVASIVE PROCEDURE; NONHUMAN; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SIGNAL DETECTION; SUBHARMONIC AIDED PRESSURE ESTIMATION; ULTRASOUND SCANNER;

ANIMALS; ARTERIAL PRESSURE; BLOOD PRESSURE DETERMINATION; CONTRAST MEDIA; DOGS; FERRIC COMPOUNDS; HYPERTENSION, PORTAL; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IRON; OXIDES; PORTAL VEIN; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; ULTRASONOGRAPHY;

EID: 84865761072     PISSN: 03015629     EISSN: 1879291X     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2012.06.013     Document Type: Article

References (59)

1. Abraldes J.G., Pasarin M., Garcia-Pagan J.C. Animal models of portal hypertension. World J Gastroenterol 2006, 12:6577-6584.
2. Adam D., Sapunar M., Burla E. On the relationship between encapsulated ultrasound contrast agent and pressure. Ultrasound Med Biol 2005, 31:673-686.
3. Andersen K.S., Jensen J.A. Ambient pressure sensitivity of microbubbles investigated through a parameter study. J Acoust Soc Am 2009, 126:3350-3358.
4. Andersen K.S., Jensen J.A. Impact of acoustic pressure on ambient pressure estimation using ultrasound contrast agent. Ultrasonics 2010, 50:294-299.
5. Baik S.K., Kim J.W., Kim H.S., Kwon S.O., Kim Y.J., Park J.W., Kim S.H., Chang S.J., Lee D.K., Han K.H., Um S.H., Lee S.S. Recent variceal bleeding: Doppler US hepatic vein waveform in assessment of severity of portal hypertension and vasoactive drug response. Radiology 2006, 240:574-580.
6. Biagi E., Breschi L., Vannacci E., Masotti L. Stable and transient subharmonic emissions from isolated contrast agent microbubbles. IEEE Trans Ultrason Ferroelectr Freq Control 2007, 54:480-497.
7. Bland J.M., Altman D.G. Multiple significance tests: The Bonferroni method. BMJ 1995, 310:170.
8. Bouakaz A., de Jong N. WFUMB Safety Symposium on Echo-Contrast Agents: Nature and types of ultrasound contrast agents. Ultrasound Med Biol 2007, 33:187-196.
9. Bouakaz A., Frinking P.J., de Jong N., Bom N. Noninvasive measurement of the hydrostatic pressure in a fluid-filled cavity based on the disappearance time of micrometer-sized free gas bubbles. Ultrasound Med Biol 1999, 25:1407-1415.
10. Buob S., Johnston A.N., Webster C.R. Portal hypertension: Pathophysiology, diagnosis, and treatment. J Vet Intern Med 2011, 25:169-186.
11. Chen Y., Zhang Q., Liao Y., Guo F., Zhang Y., Zeng Q., Jin W., Shi H., Zhou M. A modified canine model of portal hypertension with hypersplenism. Scand J Gastroenterol 2009, 44:478-485.
12. Cokkinos D.D., Dourakis S.P. Ultrasonographic assessment of cirrhosis and portal hypertension. Curr Med Imaging Rev 2009, 5:62-70.
13. D'Amico G., Garcia-Tsao G., Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: A systematic review of 118 studies. J Hepatol 2006, 44:217-231.
14. Dave J., Halldorsdottir V., Eisenbrey J., Liu J.B., McDonald M., Dickie K., Leung C., Forsberg F. Noninvasive estimation of dynamic pressures in vitro and in vivo using the subharmonic response from microbubbles. IEEE Trans Ultrason Ferroelectr Freq Control 2011, 58:2056-2066.
15. Dave J.K., Forsberg F., Fernandes S., Piccoli C.W., Fox T.B., Merton D.A., Leodore L.M., Hall A.L. Static and dynamic cumulative maximum intensity display mode for subharmonic breast imaging: A comparative study with mammographic and conventional ultrasound techniques. J Ultrasound Med 2010, 29:1177-1185.
16. Dave J.K., Halldorsdottir V.G., Eisenbrey J.R., Raichlen J.S., Liu J.B., McDonald M.E., Dickie K., Wang S., Leung C., Forsberg F. Noninvasive LV pressure estimation using subharmonic emissions from microbubbles. JACC Cardiovasc Imaging 2012, 5:87-92.
17. Dave J., Halldorsdottir V., Eisenbrey J., Park S., Dianis S., Chalek C., Merton D., Liu J., Machado P., Thomenius K., Brown D., Forsberg F. Automated power optimization for subharmonic aided pressure estimation. J Ultrasound Med 2012, 31(suppl):S44.
18. Eisenbrey J.R., Dave J.K., Halldorsdottir V.G., Merton D.A., Machado P., Liu J.B., Miller C., Gonzalez J.M., Park S., Dianis S., Chalek C.L., Thomenius K.E., Brown D.B., Navarro V., Forsberg F. Simultaneous grayscale and subharmonic ultrasound imaging on a modified commercial scanner. Ultrasonics 2011, 51:890-897.
19. Eisenbrey JR, Gonzalez JM, Dave JK, Halldorsdottir VG, Merton DA, Machado P, Miller C, Park S, Dianis S, Chalek CL, Thomenius KE, Brown DB, Forsberg F, Navarro V. Noninvasive subharmonic aided pressures estimation (SHAPE) of portal hypertension: Initial Clinical Results. Presented at The Liver Meeting 2011b. (Abstract). Available at: Accessed April 6, 2011. http://liverlearning.aasld.org/aasld/2011/thelivermeeting/13605/undefined.
20. Eisenbrey J.R., Dave J.K., Halldorsdottir V.G., Merton D.A., Machado P., Miller C., Gonzalez J.M., Park S., Dianis S., Chalek C.L., Thomenius K.E., Brown D.B., Navarro V., Forsberg F. Subharmonic aided pressure estimation in patients with suspected portal hypertension. Proc IEEE Ultrason Symp 2011, 620-623. (Abstract).
21. Faez T., Renaud G., Defontaine M., Calle S., de Jong N. Dynamic manipulation of the subharmonic scattering of phospholipid-coated microbubbles. Phys Med Biol 2011, 56:6459-6473.
22. Fairbank W.M., Scully M.O. A new noninvasive technique for cardiac pressure measurement: Resonant scattering of ultrasound from bubbles. IEEE Trans Biomed Eng 1977, 24:107-110.
23. Field A. Discovering statistics using SPSS. Discovering statistics using SPSS 2009, 191-192. SAGE Publications Ltd, London. 3rd ed.
24. Forsberg F., Liu J.B., Shi W.T., Furuse J., Shimizu M., Goldberg B.B. In vivo pressure estimation using subharmonic contrast microbubble signals: Proof of concept. IEEE Trans Ultrason Ferroelectr Freq Control 2005, 52:581-583.
25. Forsberg F., Piccoli C.W., Merton D.A., Palazzo J.J., Hall A.L. Breast lesions: Imaging with contrast-enhanced subharmonic US-initial experience. Radiology 2007, 244:718-726.
26. Frinking P.J., Brochot J., Arditi M. Subharmonic scattering of phospholipid-shell microbubbles at low acoustic pressure amplitudes. IEEE Trans Ultrason Ferroelectr Freq Control 2010, 57:1762-1771.
27. Ganor Y., Adam D., Kimmel E. Time and pressure dependence of acoustic signals radiated from microbubbles. Ultrasound Med Biol 2005, 31:1367-1374.
28. Giday S.A., Clarke J.O., Buscaglia J.M., Shin E.J., Ko C.W., Magno P., Kantsevoy S.V. EUS-guided portal vein catheterization: A promising novel approach for portal angiography and portal vein pressure measurements. Gastrointest Endosc 2008, 67:338-342.
29. Goldberg B., Raichlen J., Forsberg F. Ultrasound contrast agents: Basic principles and clinical applications 2001, Martin Dunitz, London.
30. Halldorsdottir V.G., Dave J.K., Leodore L.M., Eisenbrey J.R., Park S., Hall A.L., Thomenius K., Forsberg F. Subharmonic contrast microbubble signals for noninvasive pressure estimation under static and dynamic flow conditions. Ultrason Imaging 2011, 33:153-164.
31. Halpern E.J. Noninvasive assessment of portal hypertension-can US aid in the prediction of portal pressure and monitoring of therapy?. Radiology 2006, 240:309-310.
32. Hök B. A new approach to noninvasive manometry: Interaction between ultrasound and bubbles. Med Biol Eng Comput 1981, 19:35-39.
33. Iezzi R., Basilico R., Giancristofaro D., Pascali D., Cotroneo A.R., Storto M.L. Contrast-enhanced ultrasound versus color duplex ultrasound imaging in the follow-up of patients after endovascular abdominal aortic aneurysm repair. J Vasc Surg 2009, 49:552-560.
34. Jenkins H.P., Janda R. Studies on the use of gelatin sponge or foam as an hemostatic agent in experimental liver resections and injuries to large veins. Ann Surg 1946, 124:952-961.
35. Jin W., Deng L., Zhang Q., Lin D., Zhu J., Chen Y., Chen B., Li J. A canine portal hypertension model induced by intra-portal administration of Sephadex microsphere. J Gastroenterol Hepatol 2010, 25:778-785.
36. Katiyar A., Sarkar K., Forsberg F. Modeling subharmonic response from contrast microbubbles as a function of ambient static pressure. J Acoust Soc Am 2011, 129:2325-2335.
37. Kim M.Y., Baik S.K., Park D.H., Lim D.W., Kim J.W., Kim H.S., Kwon S.O., Kim Y.J., Chang S.J., Lee S.S. Damping index of Doppler hepatic vein waveform to assess the severity of portal hypertension and response to propranolol in liver cirrhosis: A prospective nonrandomized study. Liver Int 2007, 27:1103-1110.
38. Kim S.Y., Jeong W.K., Kim Y., Heo J.N., Kim M.Y., Kim T.Y., Sohn J.H. Changing waveform during respiration on hepatic vein Doppler sonography of severe portal hypertension: Comparison with the damping index. J Ultrasound Med 2011, 30:455-462.
39. Lafortune M., Marleau D., Breton G., Viallet A., Lavoie P., Huet P.M. Portal venous system measurements in portal hypertension. Radiology 1984, 151:27-30.
40. Landmark K.E., Johansen P.W., Johnson J.A., Johansen B., Uran S., Skotland T. Pharmacokinetics of perfluorobutane following intravenous bolus injection and continuous infusion of sonazoid in healthy volunteers and in patients with reduced pulmonary diffusing capacity. Ultrasound Med Biol 2008, 34:494-501.
41. Lebrec D., Sogni P., Vilgrain V. Evaluation of patients with portal hypertension. Baillieres Clin Gastroenterol 1997, 11:221-241.
42. Mac D.S., Matthews W.H. Fibrin foam and gelfoam in experimental kidney wounds. J Urol 1947, 57:802-811.
43. Miwa H. Pressure measuring system with ultrasonic wave.U.S. Patent 1984; 4,483,345.
44. Moan A.S. The evaluation of liver dysfunction: When to suspect portal hypertension. JAAPA 2009, 22:38-42.
45. Navarro V.J., Rossi S., Herrine S.K. Hepatic cirrhosis. Pharmacology and therapeutics: Principles to practice 2008, 505-526. Saunders, Philadelphia. S.A. Waldman, A. Terzic (Eds.).
46. Palmaz J.C., Garcia F., Sibbitt R.R., Tio F.O., Kopp D.T., Schwesinger W., Lancaster J.L., Chang P. Expandable intrahepatic portacaval shunt stents in dogs with chronic portal hypertension. Am J Roentgenol 1986, 147:1251-1254.
47. Rye K., Mortimore G., Austin A., Freeman J. Non-invasive assessment and prediction of clinically significant portal hypertension. Presented at the British Society of Gastroenterology Annual General Meeting. Gut 2011, 60:A245-A246. (abstract).
48. Sanyal A.J., Bosch J., Blei A., Arroyo V. Portal hypertension and its complications. Gastroenterology 2008, 134:1715-1728.
49. Seitchik M.W., Poll M., Rosenthal W., Baronofsky I.D. Studies in the hemodynamics following supradiaphragmatic constriction of the inferior vena cava. Ann Surg 1961, 153:71-80.
50. Shankar P.M., Chapelon J.Y., Newhouse V.L. Fluid pressure measurement using bubbles insonified by two frequencies. Ultrasonics 1986, 24:333-336.
51. Shi W.T., Forsberg F., Raichlen J., Needleman L., Goldberg B.B. Pressure dependence of subharmonic signals from contrast microbubbles. Ultrasound Med Biol 1999, 25:275-283.
52. Shi W.T., Hoff L., Forsberg F. Subharmonic performance of contrast microbubbles: An experimental and numerical investigation. Proc IEEE Ultrason Symp 2002, 2:1957-1960.
53. Sontum P.C. Physicochemical characteristics of Sonazoid, a new contrast agent for ultrasound imaging. Ultrasound Med Biol 2008, 34:824-833.
54. Sugita S., Ohnishi K., Saito M., Okuda K. Splanchnic hemodynamics in portal hypertensive dogs with portal fibrosis. Am J Physiol Gastrointest Liver Physiol 1987, 252:G748-G754.
55. Talwalkar J.A., Yin M., Venkatesh S., Rossman P.J., Grimm R.C., Manduca A., Romano A., Kamath P.S., Ehman R.L. Feasibility of in vivo MR elastographic splenic stiffness measurements in the assessment of portal hypertension. Am J Roentgenol 2009, 193:122-127.
56. Thabut D., Moreau R., Lebrec D. Noninvasive assessment of portal hypertension in patients with cirrhosis. Hepatology 2011, 53:683-694.
57. Vizzutti F., Arena U., Romanelli R.G., Rega L., Foschi M., Colagrande S., Petrarca A., Moscarella S., Belli G., Zignego A.L., Marra F., Laffi G., Pinzani M. Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis. Hepatology 2007, 45:1290-1297.
58. von Herbay A., Westendorff J., Gregor M. Contrast-enhanced ultrasound with SonoVue: Differentiation between benign and malignant focal liver lesions in 317 patients. J Clin Ultrasound 2010, 38:1-9.
59. Yamana H., Yatsuka K., Kakegawa T. Experimental production of portal hypertension in dogs by a whole liver compression. Gastroenterol Jpn 1983, 18:119-127.