Divergent Molecular Mechanisms Underlay CO- and CORM-2-Induced Relaxation of Corpora Cavernosa

Journal of Sexual Medicine

Volumn 9, Issue 9, 2012, Pages 2284-2292

  Decaluwé, Kelly ^a   Pauwels, Bart ^a   Boydens, Charlotte ^a   Van De Voorde, Johan ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Carbon Monoxide; CO Releasing Molecule 2; Corpora Cavernosa; Targets to Pharmacologically Affect Penile Erectile Tissue

Indexed keywords

CARBON MONOXIDE; CARBON MONOXIDE RELEASING MOLECULE 2; CYCLIC GMP; GUANYLATE CYCLASE; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CORPORA CAVERNOSA; ENZYME ACTIVATION; ERECTILE DYSFUNCTION; MALE; MOLECULE; MOUSE; MUSCLE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE RELAXATION; NONHUMAN; PENIS; PENIS ERECTION; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 84865732344     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2012.02831.x     Document Type: Article

References (39)

1. Decaluwé K, Pauwels B, Verpoest S, Van de Voorde J. New therapeutic targets for the treatment of erectile dysfunction. J Sex Med 2011;8:3271-90.
2. Burnett AL, Goldstein I, Andersson KE, Argiolas A, Christ G, Park K, Xin ZC. Future sexual medicine physiological treatment targets. J Sex Med 2010;7:3269-304.
3. Abdel Aziz MT, Mostafa T, Atta H, Wassef MA, Fouad HH, Rashed LA, Sabry D. Putative role of carbon monoxide signaling pathway in penile erectile function. J Sex Med 2009;6:49-60.
4. Hedlund P, Ny L, Alm P, Andersson KE. Cholinergic nerves in human corpus cavernosum and spongiosum contain nitric oxide synthase and heme oxygenase. J Urol 2000;164(3 Pt 1):868-75.
5. Abdel Aziz MT, Mostafa T, Atta H, Mahfouz S, Wassef M, Fouad H, Kamel M, Rashed L, Sabry D, Mouhamed O. Effect of HO-1 cDNA-liposome complex transfer on erectile signalling of aged rats. Andrologia 2009;41:176-83.
6. Ushiyama M, Kuramochi T, Yagi S, Katayama S. Antioxidant treatment with alpha-tocopherol improves erectile function in hypertensive rats. Hypertens Res 2008;31:1007-13.
7. Guo YG, Qin WB, Song WJ, Wang SQ. [Effect of endogenous carbon monoxide on the smooth muscle function of dog penile corpus cavernosum in vitro]. Zhonghua Nan Ke Xue 2006;12:685-8.
8. Shamloul R, Wang R. Increased intracavernosal pressure response in hypertensive rats after chronic hemin treatment. J Sex Med 2006;3:619-27.
9. Abdel Aziz MT, El Asmer MF, Mostafa T, Atta H, Mahfouz S, Fouad H, Rashed L, Sabry D, Hassouna A, Abdel Aziz AT, Senbel A, Demery A. Effects of losartan, HO-1 inducers or HO-1 inhibitors on erectile signaling in diabetic rats. J Sex Med 2009;6:3254-64.
10. Ryter SW, Otterbein LE, Morse D, Choi AM. Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance. Mol Cell Biochem 2002;234-235:249-63.
11. Motterlini R, Clark JE, Foresti R, Sarathchandra P, Mann BE, Green CJ. Carbon monoxide-releasing molecules: Characterization of biochemical and vascular activities. Circ Res 2002;90:E17-24.
12. Motterlini R, Mann BE, Johnson TR, Clark JE, Foresti R, Green CJ. Bioactivity and pharmacological actions of carbon monoxide-releasing molecules. Curr Pharm Des 2003;9:2525-39.
13. Motterlini R. Carbon monoxide-releasing molecules (CO-RMs): Vasodilatory, anti-ischaemic and anti-inflammatory activities. Biochem Soc Trans 2007;35(Pt 5):1142-6.
14. Motterlini R, Mann BE, Foresti R. Therapeutic applications of carbon monoxide-releasing molecules. Expert Opin Investig Drugs 2005;14:1305-18.
15. Motterlini R, Otterbein LE. The therapeutic potential of carbon monoxide. Nat Rev Drug Discov 2010;9:728-43.
16. De Backer O, Lefebvre RA. Mechanisms of relaxation by carbon monoxide-releasing molecule-2 in murine gastric fundus and jejunum. Eur J Pharmacol 2007;572:197-206.
17. Leffler CW, Parfenova H, Jaggar JH. Carbon monoxide as an endogenous vascular modulator. Am J Physiol Heart Circ Physiol 2011;301:H1-11.
18. Wang R. Resurgence of carbon monoxide: An endogenous gaseous vasorelaxing factor. Can J Physiol Pharmacol 1998;76:1-15.
19. Coceani F. Carbon monoxide and dilation of blood vessels. Science 1993;260:739.
20. Brian JE Jr, Heistad DD, Faraci FM. Effect of carbon monoxide on rabbit cerebral arteries. Stroke 1994;25:639-43.
21. Decaluwé K, Pauwels B, Verpoest S, Van de Voorde J. Divergent mechanisms involved in CO and CORM-2 induced vasorelaxation. Eur J Pharmacol 2012;674:370-7.
22. Morse D, Sethi J, Choi AM. Carbon monoxide-dependent signaling. Crit Care Med 2002;30(1 suppl):S12-7.
23. Wang R, Wu L, Wang Z. The direct effect of carbon monoxide on KCa channels in vascular smooth muscle cells. Pflugers Arch 1997;434:285-91.
24. McLaughlin BE, Chretien ML, Choi C, Brien JF, Nakatsu K, Marks GS. Potentiation of carbon monoxide-induced relaxation of rat aorta by YC-1 [3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole]. Can J Physiol Pharmacol 2000;78:343-9.
25. Abdel Aziz MT, El Asmer MF, Rezq A, Kumosani TA, Mostafa S, Mostafa T, Atta H, Abdel Aziz WM, Fouad HH, Rashed L, Sabry D, Hassouna AA, Senbel A, Abdel AA. Novel water-soluble curcumin derivative mediating erectile signaling. J Sex Med 2010;7:2714-22.
26. Marks GS, Brien JF, Nakatsu K, McLaughlin BE. Does carbon monoxide have a physiological function? Trends Pharmacol Sci 1991;12:185-8.
27. Durante W. Targeting heme oxygenase-1 in vascular disease. Curr Drug Targets 2010;11:1504-16.
28. Johnson FK, Teran FJ, Prieto-Carrasquero M, Johnson RA. Vascular effects of a heme oxygenase inhibitor are enhanced in the absence of nitric oxide. Am J Hypertens 2002;15:1074-80.
29. Lee CY, Yen MH. Nitric oxide and carbon monoxide, collaborative and competitive regulators of hypertension. Chang Gung Med J 2009;32:12-21.
30. Hartsfield CL, Alam J, Cook JL, Choi AM. Regulation of heme oxygenase-1 gene expression in vascular smooth muscle cells by nitric oxide. Am J Physiol 1997;273(5 Pt 1):L980-8.
31. Morse D, Sethi J. Carbon monoxide and human disease. Antioxid Redox Signal 2002;4:331-8.
32. Burnett AL, Johns DG, Kriegsfeld LJ, Klein SL, Calvin DC, Demas GE, Schramm LP, Tonegawa S, Nelson RJ, Snyder SH, Poss KD. Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2. Nat Med 1998;4:84-7.
33. Telezhkin V, Brazier SP, Mears R, Muller CT, Riccardi D, Kemp PJ. Cysteine residue 911 in C-terminal tail of human BK(Ca)alpha channel subunit is crucial for its activation by carbon monoxide. Pflugers Arch 2011;461:665-75.
34. Barbe C, Dubuis E, Rochetaing A, Kreher P, Bonnet P, Vandier C. A 4-AP-sensitive current is enhanced by chronic carbon monoxide exposure in coronary artery myocytes. Am J Physiol Heart Circ Physiol 2002;282:H2031-8.
35. Peers C. Ion channels as target effectors for carbon monoxide. Exp Physiol 2011;96:836-9.
36. Jara-Oseguera A, Ishida IG, Rangel-Yescas GE, Espinosa-Jalapa N, Perez-Guzman JA, Elias-Vinas D, Le LR, Rosenbaum T, Islas LD. Uncoupling charge movement from channel opening in voltage-gated potassium channels by ruthenium complexes. J Biol Chem 2011;286:16414-25.
37. Yousif MH, Benter IF. Role of cytochrome P450 metabolites of arachidonic acid in regulation of corporal smooth muscle tone in diabetic and older rats. Vascul Pharmacol 2007;47:281-7.
38. Foresti R, Hammad J, Clark JE, Johnson TR, Mann BE, Friebe A, Green CJ, Motterlini R. Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br J Pharmacol 2004;142:453-60.
39. Abdel Aziz MT, El-Asmar MF, Mostafa T, Atta H, Fouad HH, Roshdy NK, Rashed LA, Obaia EA, Sabry DA, Abdel Aziz AT, Drummond G, Olszanecki R. Effect of hemin and carbon monoxide releasing molecule (CORM-3) on cGMP in rat penile tissue. J Sex Med 2008;5:336-43.