The CC1-FHA tandem as a central hub for controlling the dimerization and activation of kinesin-3 KIF1A

Structure

Volumn 20, Issue 9, 2012, Pages 1550-1561

  Huo, Lin ^a,b   Yue, Yang ^a,c   Ren, Jinqi ^a   Yu, Jiang ^b,d   Liu, Junlin ^a   Yu, Yong ^a   Ye, Fei ^b   Xu, Tao ^a,c   Zhang, Mingjie ^b   Feng, Wei ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; HOMODIMER; KINESIN 3 KIF1A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CC1 FHA TANDEM; CELL STRAIN COS7; CELL STRAIN HEK293; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINESIN; MICE; MICROTUBULES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN TRANSPORT;

EID: 84865729967     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2012.07.002     Document Type: Article

References (35)

1. H. Aizawa, Y. Sekine, R. Takemura, Z. Zhang, M. Nangaku, and N. Hirokawa Kinesin family in murine central nervous system J. Cell Biol. 119 1992 1287 1296
2. J. Al-Bassam, Y. Cui, D. Klopfenstein, B.O. Carragher, R.D. Vale, and R.A. Milligan Distinct conformations of the kinesin Unc104 neck regulate a monomer to dimer motor transition J. Cell Biol. 163 2003 743 753
3. A.T. Brünger, P.D. Adams, G.M. Clore, W.L. DeLano, P. Gros, R.W. Grosse-Kunstleve, J.S. Jiang, J. Kuszewski, M. Nilges, and N.S. Pannu Crystallography & NMR system: a new software suite for macromolecular structure determination Acta Crystallogr. D Biol. Crystallogr. 54 1998 905 921
4. D.L. Coy, W.O. Hancock, M. Wagenbach, and J. Howard Kinesin's tail domain is an inhibitory regulator of the motor domain Nat. Cell Biol. 1 1999 288 292
5. P. Emsley, and K. Cowtan Coot: model-building tools for molecular graphics Acta Crystallogr. D Biol. Crystallogr. 60 2004 2126 2132
6. Y. Erlich, S. Edvardson, E. Hodges, S. Zenvirt, P. Thekkat, A. Shaag, T. Dor, G.J. Hannon, and O. Elpeleg Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis Genome Res. 21 2011 658 664
7. D.S. Friedman, and R.D. Vale Single-molecule analysis of kinesin motility reveals regulation by the cargo-binding tail domain Nat. Cell Biol. 1 1999 293 297
8. A. Gennerich, and R.D. Vale Walking the walk: how kinesin and dynein coordinate their steps Curr. Opin. Cell Biol. 21 2009 59 67
9. J.W. Hammond, D. Cai, T.L. Blasius, Z. Li, Y. Jiang, G.T. Jih, E. Meyhofer, and K.J. Verhey Mammalian Kinesin-3 motors are dimeric in vivo and move by processive motility upon release of autoinhibition PLoS Biol. 7 2009 e72
10. J.W. Hammond, T.L. Blasius, V. Soppina, D. Cai, and K.J. Verhey Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms J. Cell Biol. 189 2010 1013 1025
11. N. Hirokawa, Y. Noda, Y. Tanaka, and S. Niwa Kinesin superfamily motor proteins and intracellular transport Nat. Rev. Mol. Cell Biol. 10 2009 682 696
12. T.M. Huckaba, A. Gennerich, J.E. Wilhelm, A.H. Chishti, and R.D. Vale Kinesin-73 is a processive motor that localizes to Rab5-containing organelles J. Biol. Chem. 286 2011 7457 7467
13. D.R. Klopfenstein, M. Tomishige, N. Stuurman, and R.D. Vale Role of phosphatidylinositol(4,5)bisphosphate organization in membrane transport by the Unc104 kinesin motor Cell 109 2002 347 358
14. R.A. Laskowski, M.W. Macarthur, D.S. Moss, and J.M. Thornton Procheck - a Program to Check the Stereochemical Quality of Protein Structures J. Appl. Crystallogr. 26 1993 283 291
15. C.J. Lawrence, R.K. Dawe, K.R. Christie, D.W. Cleveland, S.C. Dawson, S.A. Endow, L.S. Goldstein, H.V. Goodson, N. Hirokawa, and J. Howard A standardized kinesin nomenclature J. Cell Biol. 167 2004 19 22
16. J.R. Lee, H. Shin, J. Choi, J. Ko, S. Kim, H.W. Lee, K. Kim, S.H. Rho, J.H. Lee, and H.E. Song An intramolecular interaction between the FHA domain and a coiled coil negatively regulates the kinesin motor KIF1A EMBO J. 23 2004 1506 1515
17. J.R. Lee, H. Shin, J. Ko, J. Choi, H. Lee, and E. Kim Characterization of the movement of the kinesin motor KIF1A in living cultured neurons J. Biol. Chem. 278 2003 2624 2629
18. X. Liang, and S.R. Van Doren Mechanistic insights into phosphoprotein-binding FHA domains Acc. Chem. Res. 41 2008 991 999
19. A. Mahajan, C. Yuan, H. Lee, E.S. Chen, P.Y. Wu, and M.D. Tsai Structure and function of the phosphothreonine-specific FHA domain Sci. Signal. 1 2008 re12
20. A.J. McCoy Solving structures of protein complexes by molecular replacement with Phaser Acta Crystallogr. D Biol. Crystallogr. 63 2007 32 41
21. G.N. Murshudov, A.A. Vagin, and E.J. Dodson Refinement of macromolecular structures by the maximum-likelihood method Acta Crystallogr. D Biol. Crystallogr. 53 1997 240 255
22. Y. Okada, H. Yamazaki, Y. Sekine-Aizawa, and N. Hirokawa The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors Cell 81 1995 769 780
23. Z. Otwinowski, and W. Minor Processing of X-ray diffraction data collected in oscillation mode. Macromolecular Crystallography Pt A 276 1997 307 326
24. J. Painter, and E.A. Merritt TLSMD web server for the generation of multi-group TLS models J. Appl. Crystallorg. 39 2006 109 111
25. M. Park, S. Watanabe, V.Y. Poon, C.Y. Ou, E.M. Jorgensen, and K. Shen CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits Neuron 70 2011 742 757
26. D.J. Rashid, J. Bononi, B.P. Tripet, R.S. Hodges, and D.W. Pierce Monomeric and dimeric states exhibited by the kinesin-related motor protein KIF1A J. Pept. Res. 65 2005 538 549
27. J.B. Rivière, S. Ramalingam, V. Lavastre, M. Shekarabi, S. Holbert, J. Lafontaine, M. Srour, N. Merner, D. Rochefort, and P. Hince KIF1A, an axonal transporter of synaptic vesicles, is mutated in hereditary sensory and autonomic neuropathy type 2 Am. J. Hum. Genet. 89 2011 219 230
28. M. Tomishige, D.R. Klopfenstein, and R.D. Vale Conversion of Unc104/KIF1A kinesin into a processive motor after dimerization Science 297 2002 2263 2267
29. J.W. Tsai, W.N. Lian, S. Kemal, A.R. Kriegstein, and R.B. Vallee Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells Nat. Neurosci. 13 2010 1463 1471
30. R.D. Vale The molecular motor toolbox for intracellular transport Cell 112 2003 467 480
31. K.J. Verhey, and J.W. Hammond Traffic control: regulation of kinesin motors Nat. Rev. Mol. Cell Biol. 10 2009 765 777
32. K.J. Verhey, N. Kaul, and V. Soppina Kinesin assembly and movement in cells Annu. Rev. Biophys. 40 2011 267 288
33. G. Woehlke, and M. Schliwa Walking on two heads: the many talents of kinesin Nat. Rev. Mol. Cell Biol. 1 2000 50 58
34. A. Yildiz, and P.R. Selvin Kinesin: walking, crawling or sliding along? Trends Cell Biol. 15 2005 112 120
35. Y. Yonekawa, A. Harada, Y. Okada, T. Funakoshi, Y. Kanai, Y. Takei, S. Terada, T. Noda, and N. Hirokawa Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice J. Cell Biol. 141 1998 431 441