Investigating the association between vitamin D deficiency and sepsis: Challenges and future prospects

Expert Review of Anti-Infective Therapy

Volumn 10, Issue 7, 2012, Pages 723-725

  Watkins, Richard R ^a,b  

^a AKRON GENERAL MEDICAL CENTER   (United States)

^b Northeast Ohio Medical University   (United States)

Author keywords

clinical trials; sepsis; vitamin D deficiency

Indexed keywords

25 HYDROXYVITAMIN D; CATHELICIDIN; COLECALCIFEROL; DROTRECOGIN; GAMMA INTERFERON; INTERLEUKIN 2; PLACEBO; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; VITAMIN D;

CAUSE OF DEATH; CONTROLLED STUDY; CRITICALLY ILL PATIENT; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; EDITORIAL; HEALTH STATUS; HELPER CELL; HUMAN; IMMUNE SYSTEM; INTENSIVE CARE UNIT; LENGTH OF STAY; MYCOBACTERIUM TUBERCULOSIS; OBSERVATIONAL STUDY; OSTEOMALACIA; PROPHYLAXIS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SEPSIS; SEPTIC SHOCK; TRANSLATIONAL RESEARCH; VITAMIN D DEFICIENCY;

HUMANS; SEPSIS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84865711516     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/eri.12.61     Document Type: Editorial

References (17)

1. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N. Engl. J. Med. 348(16), 1546-1554 (2003). (Pubitemid 36437931)
2. Angus DC. Drotrecogin α (activated). a sad final fizzle to a roller-coaster party. Crit. Care 16(1), 107 (2012).
3. Watkins RR, Yamshchikov AV, Lemonovich TL, Salata RA. The role of vitamin D deficiency in sepsis and potential therapeutic implications. J. Infect. 63(5), 321-326 (2011).
4. Holick MF. Vitamin D deficiency. N. Engl. J. Med. 357(3), 266-281 (2007).
5. Rook GA, Steele J, Fraher L et al. Vitamin D3, γ interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes. Immunology 57(1), 159-163 (1986). (Pubitemid 16232232)
6. Liu PT, Stenger S, Li H et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311(5768), 1770-1773 (2006).
7. Mahon BD, Wittke A, Weaver V, Cantorna MT. The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. J. Cell. Biochem. 89(5), 922-932 (2003). (Pubitemid 36927724)
8. Kamen DL, Tangpricha V. Vitamin D and molecular actions on the immune system: Modulation of innate and autoimmunity. J. Mol. Med. 88(5), 441-450 (2010).
9. Møller S, Laigaard F, Olgaard K, Hemmingsen C. Effect of 1,25-dihydroxyvitamin D3 in experimental sepsis. Int. J. Med. Sci. 4(4), 190-195 (2007).
10. Jeng L, Yamshchikov AV, Judd SE et al. Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J. Transl. Med. 7, 28 (2009).
11. Braun AB, Gibbons FK, Litonjua AA, Giovannucci E, Christopher KB. Low serum 25-hydroxyvitamin D at critical care initiation is associated with increased mortality. Crit. Care Med. 40(1), 63-72 (2012).
12. Flynn L, Zimmerman LH, McNorton K et al. Effects of vitamin D deficiency in critically ill surgical patients. Am. J. Surg. 203(3), 379-382; discussion 382 (2012).
13. Ginde AA, Camargo CA Jr, Shapiro NI. Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infection. Acad. Emerg. Med. 18(5), 551-554 (2011).
14. Danai PA, Sinha S, Moss M, Haber MJ, Martin GS. Seasonal variation in the epidemiology of sepsis. Crit. Care Med. 35(2), 410-415 (2007). (Pubitemid 46148529)
15. Laaksi I, Ruohola JP, Mattila V, Auvinen A, Ylikomi T, Pihlajamäki H. Vitamin D supplementation for the prevention of acute respiratory tract infection: A randomized, double-blinded trial among young Finnish men. J. Infect. Dis. 202(5), 809-814 (2010).
16. Martineau AR, Timms PM, Bothamley GH et al. High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: A double-blind randomised controlled trial. Lancet 377(9761), 242-250 (2011).
17. Khoo AL, Chai L, Koenen H, Joosten I, Netea M, van der Ven A. Translating the role of vitamin D3 in infectious diseases. Crit. Rev. Microbiol. 38(2), 122-135 (2012).