Atypical fluoroquinolone gold(III) chelates as potential anticancer agents: Relevance of DNA and protein interactions for their mechanism of action

European Journal of Medicinal Chemistry

Volumn 55, Issue , 2012, Pages 67-73

  Gouvea, Ligiane R ^a   Garcia, Luciene S ^b   Lachter, Daniela R ^b   Nunes, Paula Roberta ^c   De Castro Pereira, Flávia ^c   Silveira Lacerda, Elisângela P ^c   Louro, Sônia R W ^b   Barbeira, Paulo Jorge S ^a   Teixeira, Letícia R ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

Author keywords

Cytotoxic activity; Fluoroquinolones; Gold(III) complexes; Interaction with bovine serum albumin; Interaction with calf thymus DNA

Indexed keywords

ANTINEOPLASTIC AGENT; BOVINE SERUM ALBUMIN; CHLORIDE ION; DNA; GOLD COMPLEX; LEVOFLOXACIN; LIGAND; NITROGEN; NORFLOXACIN; PIPERAZINE; QUINOLONE DERIVATIVE; SPARFLOXACIN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; ATOM; CALF (BOVINE); CELL CYCLE ARREST; CELL TYPE; CHELATION; CHEMICAL BINDING; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROSCOPY; LEUKEMIA CELL LINE; LUNG FIBROBLAST; LYMPHOMA CELL; LYMPHOMA CELL LINE; MASS SPECTROMETRY; MELANOMA B16; MELANOMA CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; PROTEIN DNA INTERACTION; RING OPENING; THYMUS; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; CATTLE; CELL CYCLE; CELL LINE, TUMOR; CHELATING AGENTS; DNA; DNA FRAGMENTATION; FLUOROQUINOLONES; HUMANS; INHIBITORY CONCENTRATION 50; MICE; ORGANOGOLD COMPOUNDS; SERUM ALBUMIN, BOVINE;

EID: 84865710820     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.07.004     Document Type: Article

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