Expressions of matrix metalloproteinase-9 (MMP-9), dentin sialophosphoprotein (DSPP), and osteopontin (OPN) at histologically negative surgical margins may predict recurrence of oral squamous cell carcinoma

Oncotarget

Volumn 3, Issue 3, 2012, Pages 286-298

  Ogbureke, Kalu U E ^a   Weinberger, Paul M ^a   Looney, Stephen W ^a   Li, Li ^b   Fisher, Larry W ^b  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

BSP; DSPP; MMPs, Tumor free margin; OPN; Oral cancer

Indexed keywords

DENTIN SIALOPHOSPHOPROTEIN; GELATINASE B; OSTEOPONTIN; PHOSPHOPROTEIN; SCLEROPROTEIN; SIALOGLYCOPROTEIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; BIOLOGICAL MODEL; DISEASE FREE SURVIVAL; EVALUATION; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LABORATORY DIAGNOSIS; MALE; METABOLISM; MIDDLE AGED; MOUTH TUMOR; PATHOLOGY; PROGNOSIS; RETROSPECTIVE STUDY; SQUAMOUS CELL CARCINOMA; TUMOR RECURRENCE;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; DISEASE-FREE SURVIVAL; EXTRACELLULAR MATRIX PROTEINS; FALSE NEGATIVE REACTIONS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; MODELS, BIOLOGICAL; MOUTH NEOPLASMS; NEOPLASM RECURRENCE, LOCAL; OSTEOPONTIN; PHOSPHOPROTEINS; PROGNOSIS; RETROSPECTIVE STUDIES; SIALOGLYCOPROTEINS; TUMOR MARKERS, BIOLOGICAL;

EID: 84865700939     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.373     Document Type: Article

References (24)

1. Weijers M, Snow GB, Bezemer DP, et al. The status of the deep surgical margins in tongue and floor of mouth squamous cell carcinoma and risk of local recurrence; an analysis of 68 patients. Int J Oral Maxillofac Surg. 33:146-149, 2004.
2. Spiro RH, Guillamondegui O Jr., Paulino AF, et al. Pattern of invasion and margin assessment in patients with oral tongue cancer. Head Neck. 21: 408-413, 1999.
3. Sieczka E, Datta R, Singh A, et al. Cancer of the buccal mucosa: are margins and T-stage accurate predictors of local control? Am J Otolaryngol. 22:395-399, 2001.
4. Nathan CA, Franklin S, Abreo FW, et al. Analysis of surgical margins with the molecular marker eIF4E: a prognostic factor in patients with head and neck cancer. J Clin Oncol. 17: 2909-2914, 1999.
5. Nathan CA, Amirghahri N, Rice C, et al. Molecular analysis of surgical margins in head and neck squamous cell carcinoma patients. Laryngoscope. 112: 2129-2140, 2002.
6. Nathan CA, Amirghahari N, Abreo F, et al. Overexpressed eIF4E is functionally active in surgical margins of head and neck cancer patients via activation of the Akt/mammalian target of rapamycin pathway. Clin Cancer Res. 10: 5820-5827, 2004.
7. Smeele LE, Leemans CR, Langendijk JA, et al. Positive surgical margins in neck dissection specimens in patients with head and neck squamous cell carcinoma and the effect of radiotherapy. Head Neck. 22:559-563, 2000.
8. Ball VA, Righi PD, Tejada E, et al. p53 immunostaining of surgical margins as a predictor of local recurrence in squamous cell carcinoma of the oral cavity and oropharynx. Ear Nose Throat J. 76:818-823, 1997.
9. Nathan CA, Sanders K, Abreo FW, et al. Correlation of p53 and the proto-oncogene eIF4E in larynx cancers: prognostic implications. Cancer Res. 60:3599-3604, 2000.
10. Fisher LW, Fedarko NS. Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins. Connect Tissue Res. S44: 33-44, 2003 (Suppl. 1).
11. Bellahcène A, Castronovo V, Ogbureke KU, et al. Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer. Nat Rev Cancer. 8: 212-226, 2008.
12. Ogbureke, K.U. Nikitakis NG, Warburton G, et al. Upregulation of SIBLING proteins and correlation with cognate MMP expression in oral cancer. Oral Oncol. 43: 920-932, 2007.
13. Ogbureke KU, Abdelsayed RA, Kushner H, et al. Two members of the SIBLING family of proteins, DSPP and BSP, may predict the transition of oral epithelial dysplasia to oral squamous cell carcinoma. Cancer. 116:1709-1717, 2010.
14. Fedarko NS, Jain A, Karadag A, Fisher LW. Three small integrin binding ligand N-linked glycoproteins (SIBLINGs) bind and activate specific matrix metalloproteinases. FASEB J. 18: 734-736.
15. Ogbureke KU, Fisher LW. Expression of SIBLINGs and their partner MMPs in salivary glands. J Dent Res. 83: 664-670, 2004.
16. Ogbureke KU, Fisher LW. Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs). Kidney Int. 68: 155-166, 2005.
17. Upile T, Fisher C, Jerjes W, et al. The uncertainty of the surgical margin in the treatment of head and neck cancer. Oral Oncol. 43: 321-326, 2007.
18. Partridge M, Li SR, Pateromichelakis S, et al. Detection of minimal residual cancer to investigate why oral tumors recur despite seemingly adequate treatment. Clin Cancer Res. 6:2718-2725, 2000.
19. Tsui IF, Garnis C, Poh CF. A dynamic oral cancer field: unraveling the underlying biology and its clinical implication. Am J Surg Pathol. 33:1732-1738, 2009.
20. Bedi GC, Westra WH, Gabrielson E, et al. Multiple head and neck tumors: evidence for a common clonal origin. Cancer Res. 56:2484-2487, 1996.
21. Eckert MA, Yang J. Targeting invadopodia to block breast cancer metastasis. Oncotarget. 2:562-568, 2011.
22. Zlobec I, Lugli A. Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget. Oncotarget. 1:651-61, 2010.
23. Braakhuis BJ, Tabor MP, Kummer JA, et al. A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. Cancer Res. 63:1727-1730, 2003.
24. Braakhuis BJ, Leemans CR, Brakenhoff RH. Expanding fields of genetically altered cells in head and neck squamous carcinogenesis. Semin Cancer Biol. 15:113-120, 2005.